Self-assembled, redox-sensitive, H-shaped pegylated methotrexate conjugates with high drug-carrying capability for intracellular drug delivery

MedChemComm ◽  
2014 ◽  
Vol 5 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Haiqing Dong ◽  
Chunyan Dong ◽  
Wenjuan Xia ◽  
Yongyong Li ◽  
Tianbin Ren
Keyword(s):  
Drug Delivery ◽  
High Drug ◽  
Intracellular Drug Delivery ◽  
Self Assembled

Folate-mediated and doxorubicin-conjugated poly(ε-caprolactone)-g-chondroitin sulfate copolymers for enhanced intracellular drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (103) ◽  
pp. 59548-59557 ◽  
Author(s):  
Yu-Sheng Liu ◽  
Hsuan-Ying Chen ◽  
Jay-An Yeh ◽  
Li-Fang Wang
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Chondroitin Sulfate ◽  
Anticancer Drug ◽  
Intracellular Drug Delivery ◽  
Folate Targeting ◽  
Self Assembled

The aim of this study was to conjugate an anticancer drug, doxorubicin (DOX) and a folate targeting moiety, folic acid (FA), to self-assembled polycaprolactone (PCL)-graft-chondroitin sulfate (CS) copolymers for enhanced chemotherapy.

scholarly journals Fabrication of self-assembled nanostructures for intracellular drug delivery from diphenylalanine analogues with rigid or flexible chemical linkers

2021 ◽  
Author(s):  
Amutha Arul ◽  
Priya Rana ◽  
Kiran Das ◽  
Ieshita Pan ◽  
Debasish Mandal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Building Blocks ◽  
Intracellular Drug Delivery ◽  
Self Assembled

Three newly synthesized building blocks, in which two FF dipeptide were connected through three different linkers, self-assemble into different super-structures with morphological individualities, considered as potential candidates for drug delivery.

Biomimetic pseudopolyrotaxane prodrug micelles with high drug content for intracellular drug delivery

2013 ◽  
Vol 49 (64) ◽  
pp. 7123 ◽  
Author(s):  
Yin Wang ◽  
Haibo Wang ◽  
Yangjun Chen ◽  
Xiangsheng Liu ◽  
Qiao Jin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
High Drug ◽  
Drug Content ◽  
Intracellular Drug Delivery

scholarly journals Mitochondrial Dysfunction–Induced Apoptosis in Breast Carcinoma Cells Through pH-Dependent Intracellular Quercetin NDDS of PVPylated-TiO2NPs

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 215s-215s
Author(s):  
T. Ponraj ◽  
S. Kannan
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Loading ◽  
Drug Dose ◽  
Cellular Level ◽  
System Level ◽  
High Drug ◽  
Intracellular Drug Delivery ◽  
Ph Dependent

Background: The conventional chemotherapy has some noticeable drawbacks, such as lack of specificity, the requirement of high drug-dose, adverse effects, and gradual development of multidrug resistance (MDR), that reduce the efficacy of cancer therapy. Aim: To achieve intracellular drug delivery, strategies for overcoming various biologic barriers from the system level to the organ level, to the cellular level. To win through over these challenges in chemotherapy is to be achieving high drug loading combination with low leakage at physiologic pH, minimal toxicity toward healthy cells, and tunable controlled release at the site of action is an ongoing challenge. Methods: To assist drug delivery, we have prepared PVPylated-TiO2NPs consisting of Qtn with high loading efficiency (26.6% w/w) for NDDS. Qtn-PVPylated-TiO2NPs uptake via endocytosed by cancer cells able to generate intracellular ROS, to decrease the mitochondrial membrane potential loss (Δψm) to release cytochrome- c, Bcl-2 dysregulation into the cytosol and then activating caspase-3 to induce cancer cell apoptosis. Results: These novel nanocombinations can be used to improve cancer nanotherapy by induction of apoptosis in vitro. Analysis at molecular level revealed that Qtn-PVPylated-TiO2NPs nanocombination induced Δψm-mediated apoptotic signaling pathway. Conclusion: To our knowledge, this is a novel report using Qtn-PVPylated-TiO2NPs nanocombinations to study the pH-dependent intracellular NDDS to cancer cells. This new nanoformulations of this study may further advance the use of Qtn-PVPylated-TiO2NPs based nanotherapeutic of biomaterials for various biomedical applications, especially cancer nanotherapy.

Bioreducible Micelles Self-Assembled from Amphiphilic Hyperbranched Multiarm Copolymer for Glutathione-Mediated Intracellular Drug Delivery

2011 ◽  
Vol 12 (5) ◽  
pp. 1567-1577 ◽  
Author(s):  
Jinyao Liu ◽  
Yan Pang ◽  
Wei Huang ◽  
Xiaohua Huang ◽  
Lili Meng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intracellular Drug Delivery ◽  
Self Assembled

Redox-responsive micelles self-assembled from dynamic covalent block copolymers for intracellular drug delivery

2015 ◽  
Vol 17 ◽  
pp. 193-200 ◽  
Author(s):  
Qinglai Yang ◽  
Lianjiang Tan ◽  
Changyu He ◽  
Bingya Liu ◽  
Yuhong Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Self Assembled

Doxorubicin Loaded Nanoparticle Consisting of Chitosan and Mannose Modified Graphene Oxide for Intracellular Drug Delivery and Anti-tumor Activity

2020 ◽  
Vol 13 (5) ◽  
pp. 5155-5164
Author(s):  
Meena K. S. ◽  
Sonia K ◽  
Alamelu Bai S
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Release ◽  
Cancer Drug ◽  
Hemolysis Assay ◽  
Functionalized Graphene Oxide ◽  
Intracellular Drug Delivery ◽  
Modified Graphene Oxide

In order to develop the efficiency and the specificity of anticancer drug delivery, we have designed an innovative nanocarrier. The nanocarrier system comprises of a multifunctional graphene oxide nanoparticle-based drug delivery system (GO-CS-M-DOX) as a novel platform for intracellular drug delivery of doxorubicin (DOX). Firstly, graphene oxide (GO) was synthesized by hummer’s method whose surface was functionalized by chitosan (CS) in order to obtain a more precise drug delivery, the system was then decorated with mannose (M). Further conjugation of an anti-cancer drug doxorubicin to the nanocarrier system resulted in GO-CS-M-DOX drug delivery system. The resultant conjugate was characterized for its physio-chemical properties and its biocompatibility was evaluated via hemolysis assay. The drug entrapment efficiency is as high as 90% and in vitro release studies of DOX under pH 5.3 is significantly higher than that under pH 7.4. The anticancer activity of the synthesized drug delivery system was studied by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay against MCF-7 cell line. These results stated that the pH dependent multifunctional doxorubicin- chitosan functionalized graphene oxide based nanocarrier system, could lead to a promising and potential platform for intracellular delivery and cytotoxicity activity for variety of anticancer drugs.   

Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

2018 ◽  
Vol 23 (35) ◽  
Author(s):  
Sally Sabra ◽  
Mona Abdelmoneem ◽  
Mahmoud Abdelwakil ◽  
Moustafa Taha Mabrouk ◽  
Doaa Anwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
Natural Polymers ◽  
Anti Cancer ◽  
Drug Delivery Applications ◽  
Self Assembled ◽  
Cancer Drug Delivery
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