Non-Destructive Molecular FTIR Spectromicroscopy for Real Time Assessment of Redox Metallodrugs

2021 ◽  
Author(s):  
Lucyano J. A. Macedo ◽  
Fernando Postalli Postalli Rodrigues ◽  
Ayaz Hassan ◽  
Leandro Maximo ◽  
Fabio Zobi ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Redox Chemistry ◽  
Biological Chemistry ◽  
Recent Emergence ◽  
Non Destructive ◽  
Time Assessment

Recent emergence of FTIR spectromicroscopy (micro-FTIR) as a dynamic spectroscopy for imaging to the study of biological chemistry has opened new possibilities for investigating in situ drug release, redox chemistry...

scholarly journals Non-destructive mid-IR spectroscopy with quantum cascade laser can detect ethylene gas dynamics of apple cultivar ‘Fuji’ in real time

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masaki Yumoto ◽  
Yasushi Kawata ◽  
Tetsuya Abe ◽  
Tomoki Matsuyama ◽  
Satoshi Wada
Keyword(s):  
Real Time ◽  
Quantum Cascade Laser ◽  
Detection System ◽  
Gas Cell ◽  
Sampling System ◽  
Gas Sampling ◽  
Quantum Cascade ◽  
Concentration Changes ◽  
Non Destructive

AbstractMany plants, including fruits and vegetables, release biogenic gases containing various volatile organic compounds such as ethylene (C2H4), which is a gaseous phytohormone. Non-destructive and in-situ gas sampling technology to detect trace C2H4 released from plants in real time would be attractive for visualising the ageing, ripening, and defence reactions of plants. In this study, we developed a C2H4 detection system with a detection limit of 0.8 ppb (3σ) using laser absorption spectroscopy. The C2H4 detection system consists of a mid-infrared quantum cascade laser oscillated at 10.5 µm, a multi-pass gas cell, a mid-IR photodetector, and a gas sampling system. Using non-destructive and in-situ gas sampling, while maintaining the internal pressure of the multi-pass gas cell at low pressure, the change in trace C2H4 concentration released from apples (Malus domestica Borkh.) can be observed in real time. We succeeded in observing C2H4 concentration changes with a time resolution of 1 s, while changing the atmospheric gas and surface temperature of apples from the ‘Fuji’ cultivar. This technique allows the visualisation of detailed C2H4 dynamics in plant environmental response, which may be promising for further progress in plant physiology, agriculture, and food science.

Ratiometric and Time-Resolved Fluorimetry from Quantum Dots Featuring Drug Carriers for Real-Time Monitoring of Drug Release in Situ

2014 ◽  
Vol 86 (11) ◽  
pp. 5211-5214 ◽  
Author(s):  
Rijun Gui ◽  
Ajun Wan ◽  
Yalei Zhang ◽  
Huili Li ◽  
Tingting Zhao
Keyword(s):  
Quantum Dots ◽  
Drug Release ◽  
Real Time ◽  
Drug Carriers ◽  
Real Time Monitoring ◽  
Time Resolved

A Dual-FRET-Based Versatile Prodrug for Real-Time Drug Release Monitoring and In Situ Therapeutic Efficacy Evaluation

2015 ◽  
Vol 25 (47) ◽  
pp. 7317-7326 ◽  
Author(s):  
Shi-Ying Li ◽  
Li-Han Liu ◽  
Lei Rong ◽  
Wen-Xiu Qiu ◽  
Hui-Zhen Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Therapeutic Efficacy ◽  
Efficacy Evaluation

On the Use of Amperometry for Real Time Assessment of Drug-Release Profile from Therapeutic Nanoparticles

2014 ◽  
Vol 26 (4) ◽  
pp. 776-785 ◽  
Author(s):  
Ali A. Ensafi ◽  
Esmaeil Heydari-Bafrooei ◽  
Behzad Rezaei
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Release Profile ◽  
Drug Release Profile ◽  
Time Assessment

Role and levels of real-time monitoring for successful anti-fouling strategies - an overview

2003 ◽  
Vol 47 (5) ◽  
pp. 1-8 ◽  
Author(s):  
H.-C. Flemming
Keyword(s):  
Real Time ◽  
Biological Information ◽  
Chemical Information ◽  
Surface Sampling ◽  
Biofilm Growth ◽  
Physico Chemical ◽  
On Line ◽  
Real Time Information ◽  
Non Destructive

Biofouling is a biofilm problem and any anti-fouling strategy will be greatly improved if the site and extent of biofilm growth can be monitored. A suitable monitoring system will provide early warning capacity and allow for specific optimization of countermeasures. As water samples do not give reliable information about biofilms, surface sampling is mandatory. Conventional biofilm monitoring techniques rely on removal of material from representative sites or on analysis of test surfaces which have been exposed. This procedure is time consuming and, depending on the parameters to be measured, requires skilled laboratory personnel. There is a strong demand for direct, on-line, in situ, continuous, non-destructive real-time information about biofilms in a system. Such demands can only be fulfilled by physical or physico-chemical methods, a number of which have already been successfully applied for biofilm monitoring. It is important, however, to be aware of the actual parameter they refer to in order to interpret the data properly. Three levels of information can be identified: (i) systems which detect increase and decrease of material accumulating on a surface but cannot differentiate between biomass and other components of a deposit, (ii) systems which provide biological information and distinguish between biotic and abiotic material, and (iii) systems which provide detailed chemical information. Examples for all three levels are presented and discussed.

Enzyme-responsive fluorescent camptothecin prodrug/polysaccharide supramolecular assembly for targeted cellular imaging and in situ controlled drug release

2020 ◽  
Vol 56 (7) ◽  
pp. 1042-1045 ◽  
Author(s):  
Yu-Hui Zhang ◽  
Ying-Ming Zhang ◽  
Xianliang Sheng ◽  
Jie Wang ◽  
Yu Liu
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Supramolecular Assembly ◽  
Controlled Drug Release ◽  
Cellular Imaging ◽  
Targeted Imaging ◽  
Real Time Tracking ◽  
Low Cytotoxicity

An enzyme-responsive polysaccharide assembly was constructed, which possesses low cytotoxicity, targeted imaging and controlled drug release, while providing a concurrent means for the real-time tracking of drug delivery.

Probing the Dynamic Self-Assembly Behaviour of Photoswitchable Wormlike Micelles in Real Time

2018 ◽  
Author(s):  
Elaine A. Kelly ◽  
Judith E. Houston ◽  
Rachel Evans
Keyword(s):  
Real Time ◽  
Absorption Spectroscopy ◽  
Self Assembly ◽  
Uv Light ◽  
Wormlike Micelles ◽  
Tetraethylene Glycol ◽  
Light Illumination ◽  
First Time ◽  
Dependent Processes

Understanding the dynamic self-assembly behaviour of azobenzene photosurfactants (AzoPS) is crucial to advance their use in controlled release applications such as<i></i>drug delivery and micellar catalysis. Currently, their behaviour in the equilibrium <i>cis-</i>and <i>trans</i>-photostationary states is more widely understood than during the photoisomerisation process itself. Here, we investigate the time-dependent self-assembly of the different photoisomers of a model neutral AzoPS, <a>tetraethylene glycol mono(4′,4-octyloxy,octyl-azobenzene) </a>(C<sub>8</sub>AzoOC<sub>8</sub>E<sub>4</sub>) using small-angle neutron scattering (SANS). We show that the incorporation of <i>in-situ</i>UV-Vis absorption spectroscopy with SANS allows the scattering profile, and hence micelle shape, to be correlated with the extent of photoisomerisation in real-time. It was observed that C<sub>8</sub>AzoOC<sub>8</sub>E<sub>4</sub>could switch between wormlike micelles (<i>trans</i>native state) and fractal aggregates (under UV light), with changes in the self-assembled structure arising concurrently with changes in the absorption spectrum. Wormlike micelles could be recovered within 60 seconds of blue light illumination. To the best of our knowledge, this is the first time the degree of AzoPS photoisomerisation has been tracked <i>in</i><i>-situ</i>through combined UV-Vis absorption spectroscopy-SANS measurements. This technique could be widely used to gain mechanistic and kinetic insights into light-dependent processes that are reliant on self-assembly.

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