A Dual-FRET-Based Versatile Prodrug for Real-Time Drug Release Monitoring and In Situ Therapeutic Efficacy Evaluation

2015 ◽  
Vol 25 (47) ◽  
pp. 7317-7326 ◽  
Author(s):  
Shi-Ying Li ◽  
Li-Han Liu ◽  
Lei Rong ◽  
Wen-Xiu Qiu ◽  
Hui-Zhen Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Therapeutic Efficacy ◽  
Efficacy Evaluation

Ratiometric and Time-Resolved Fluorimetry from Quantum Dots Featuring Drug Carriers for Real-Time Monitoring of Drug Release in Situ

2014 ◽  
Vol 86 (11) ◽  
pp. 5211-5214 ◽  
Author(s):  
Rijun Gui ◽  
Ajun Wan ◽  
Yalei Zhang ◽  
Huili Li ◽  
Tingting Zhao
Keyword(s):  
Quantum Dots ◽  
Drug Release ◽  
Real Time ◽  
Drug Carriers ◽  
Real Time Monitoring ◽  
Time Resolved

Non-Destructive Molecular FTIR Spectromicroscopy for Real Time Assessment of Redox Metallodrugs

2021 ◽  
Author(s):  
Lucyano J. A. Macedo ◽  
Fernando Postalli Postalli Rodrigues ◽  
Ayaz Hassan ◽  
Leandro Maximo ◽  
Fabio Zobi ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Redox Chemistry ◽  
Biological Chemistry ◽  
Recent Emergence ◽  
Non Destructive ◽  
Time Assessment

Recent emergence of FTIR spectromicroscopy (micro-FTIR) as a dynamic spectroscopy for imaging to the study of biological chemistry has opened new possibilities for investigating in situ drug release, redox chemistry...

Multifunctional titanium phosphate nanoparticles for site-specific drug delivery and real-time therapeutic efficacy evaluation

The Analyst ◽  
2019 ◽  
Vol 144 (9) ◽  
pp. 3103-3110 ◽  
Author(s):  
Fang-Fang Cheng ◽  
Panpan Sun ◽  
Wei-Wei Xiong ◽  
Yi Zhang ◽  
Qiao Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Real Time ◽  
Therapeutic Efficacy ◽  
Titanium Phosphate ◽  
Specific Drug ◽  
Efficacy Evaluation ◽  
Site Specific

Folic acid (FA)-functionalized DHE-modified TiP (TiP-PAH-DHE-FA) nanoparticles were synthesized for site-specific drug delivery and real-time therapeutic efficacy evaluation.

Enzyme-responsive fluorescent camptothecin prodrug/polysaccharide supramolecular assembly for targeted cellular imaging and in situ controlled drug release

2020 ◽  
Vol 56 (7) ◽  
pp. 1042-1045 ◽  
Author(s):  
Yu-Hui Zhang ◽  
Ying-Ming Zhang ◽  
Xianliang Sheng ◽  
Jie Wang ◽  
Yu Liu
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Supramolecular Assembly ◽  
Controlled Drug Release ◽  
Cellular Imaging ◽  
Targeted Imaging ◽  
Real Time Tracking ◽  
Low Cytotoxicity

An enzyme-responsive polysaccharide assembly was constructed, which possesses low cytotoxicity, targeted imaging and controlled drug release, while providing a concurrent means for the real-time tracking of drug delivery.

Probing the Dynamic Self-Assembly Behaviour of Photoswitchable Wormlike Micelles in Real Time

2018 ◽  
Author(s):  
Elaine A. Kelly ◽  
Judith E. Houston ◽  
Rachel Evans
Keyword(s):  
Real Time ◽  
Absorption Spectroscopy ◽  
Self Assembly ◽  
Uv Light ◽  
Wormlike Micelles ◽  
Tetraethylene Glycol ◽  
Light Illumination ◽  
First Time ◽  
Dependent Processes

Understanding the dynamic self-assembly behaviour of azobenzene photosurfactants (AzoPS) is crucial to advance their use in controlled release applications such as<i></i>drug delivery and micellar catalysis. Currently, their behaviour in the equilibrium <i>cis-</i>and <i>trans</i>-photostationary states is more widely understood than during the photoisomerisation process itself. Here, we investigate the time-dependent self-assembly of the different photoisomers of a model neutral AzoPS, <a>tetraethylene glycol mono(4′,4-octyloxy,octyl-azobenzene) </a>(C<sub>8</sub>AzoOC<sub>8</sub>E<sub>4</sub>) using small-angle neutron scattering (SANS). We show that the incorporation of <i>in-situ</i>UV-Vis absorption spectroscopy with SANS allows the scattering profile, and hence micelle shape, to be correlated with the extent of photoisomerisation in real-time. It was observed that C<sub>8</sub>AzoOC<sub>8</sub>E<sub>4</sub>could switch between wormlike micelles (<i>trans</i>native state) and fractal aggregates (under UV light), with changes in the self-assembled structure arising concurrently with changes in the absorption spectrum. Wormlike micelles could be recovered within 60 seconds of blue light illumination. To the best of our knowledge, this is the first time the degree of AzoPS photoisomerisation has been tracked <i>in</i><i>-situ</i>through combined UV-Vis absorption spectroscopy-SANS measurements. This technique could be widely used to gain mechanistic and kinetic insights into light-dependent processes that are reliant on self-assembly.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

Flat Flexible Thin Milli-electrode Array for Real-time in situ Water Quality Monitoring in Distribution Systems

2017 ◽  
Vol 2017 (4) ◽  
pp. 5598-5617
Author(s):  
Zhiheng Xu ◽  
Wangchi Zhou ◽  
Qiuchen Dong ◽  
Yan Li ◽  
Dingyi Cai ◽  
...  
Keyword(s):  
Water Quality ◽  
Real Time ◽  
Distribution Systems ◽  
Electrode Array ◽  
Water Quality Monitoring ◽  
Quality Monitoring
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