On the Use of Amperometry for Real Time Assessment of Drug-Release Profile from Therapeutic Nanoparticles

2014 ◽  
Vol 26 (4) ◽  
pp. 776-785 ◽  
Author(s):  
Ali A. Ensafi ◽  
Esmaeil Heydari-Bafrooei ◽  
Behzad Rezaei
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Release Profile ◽  
Drug Release Profile ◽  
Time Assessment

scholarly journals Swelling and Erosion Modulation of Sterculia Foetida Gum Through Real Time Texture Probing

1970 ◽  
Vol 7 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Bendgude Namdeo ◽  
Iyer Vidya ◽  
Poddar Sushilkumar
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Real Time ◽  
Microcrystalline Cellulose ◽  
Release Profile ◽  
Water Soluble ◽  
Matrix Tablets ◽  
Diltiazem Hydrochloride ◽  
Drug Release Profile ◽  
Water Soluble Drug

In the present investigation an attempt has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance by developing controlled release matrix tablets of diltiazem hydrochloride. Diltiazem hydrochloride was formulated as oral controlled release matrix tablets by using sterculia foetida gum. SFG fines were characterized with scanning electron microscopy. The purpose of this study was to optimize release profile of the highly water soluble drug from SFG matrix by using water soluble and swellable excipients like lactose and microcrystalline cellulose respectively. Tablets were prepared by direct compression, and their swelling behavior in presence of these excipients was assessed with the help of a Texture Analyzer. Dissolution assessment was performed using USP 26 apparatus 2 modified by insertion of a mesh to prevent sticking of the tablets to the bottom of vessel and allow them to swell three dimensionally. The interdependence of swelling front movement in relation to excipients type and progression of drug release are explained. It was concluded that unlike in conventional dosage forms insertion of excipients in hydrophilic controlled release tablets containing a water soluble drug gave the finger print information of drug release profile. In vitro drug release from these matrices was characterized and confirmed with the help of real time texture probing. Results indicated that it is possible to achieve desired modulation in the drug release profile by inclusion of lactose and microcrystalline cellulose. Key words: Diltiazem HCl, Sterculia Foetida Gum, Swelling and erosion, Lactose, Texture analysis. doi: 10.3329/dujps.v7i2.2167 Dhaka Univ. J. Pharm. Sci. 7(2): 127-132, 2008 (December)

Anticancer Nano Formulation of Imatinib with Chitosan Polymer

2019 ◽  
Vol 9 (01) ◽  
pp. 58-64
Author(s):  
Senthilnathan B ◽  
Billy Graham R ◽  
Chaarmila Sherin C ◽  
Vivekanandan K ◽  
Bhavya E
Keyword(s):  
Drug Release ◽  
Drug Targeting ◽  
Bone Marrow Failure ◽  
Lymphoblastic Leukemia ◽  
Release Profile ◽  
Nano Particles ◽  
Drug Release Profile ◽  
Study Results ◽  
Mast Cell Disease ◽  
Nano Formulation

Objective: Drug targeting is the capacity of the dosage form. In which the therapeutic agent acts specifically to desired site of action in the non-targeted tissue with the help of Nano particles is called as the drug targeting. IMATINIB is a used to treat cancer by chemo therapy. Cancers like chronic myeloid leukemia cancer (CML) and acute lymphoblastic leukemia cancer (ALL) and other specific types of gastrointestinal stromal cell tumor (GIST) systemic mast cell disease and Bone marrow failure disorder. It is administered by oral root. For ATP, Tyrosine kinase is act as a binding site. Methodology: The drug IMATINIB is loaded in the polymer chitosan, poly-(D) glucosamine is a bio compactible, bio degradable, nontoxic, antimicrobial and soluble in solvents. This preparation is done by emulsion-droplet coalescence method. Content of the Drug, Size of the particle and Zeta potential, Encapsulation efficiency and Drug release testing are described for this formulation in this study. Results: The Imatinib Nano particles were formulated and evaluated for its invitro drug release profile. Based on the invitro drug release profile of Imatinib nano particles formulation (INP1 – INP5) formulation INP3 was selected as the best formulation in which the particle size was 285.9nm. The invitro % drug release of INP3 formulation was 99.76 ± 0.82 and it was found to be the suitable formulation to manage the cancer. Conclusion: Hence it is concluded that the newly formulated controlled release nanoparticle drug delivery system of Imatinib may be idol and effective by allowing the drug to release continuously for 24 hrs.

scholarly journals Effect of a co-processed excipient on the disintegration and drug release profile of ibuprofen tablets

Bio-Research ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
BB Mohammed ◽  
EJ John ◽  
NK Ajuji
Keyword(s):  
Drug Release ◽  
Release Profile ◽  
Angle Of Repose ◽  
Oral Dosage ◽  
Direct Compression ◽  
Drug Release Profile ◽  
Disintegration Time ◽  
Crushing Strength ◽  
Tablet Properties ◽  
Spray Dried

Tablets at present, remain the most preferred oral dosage form because of many advantages they offer to formulators as well as physicians and patients. The objective of this work was to determine the effect of co-processing on the disintegration and drug-release profile of ibuprofen tablets prepared from a co-processed excipient. The co-processed excipient (CE) containing lactose, gelatin and mucin in the ratio 90:9:1 was prepared using co-fusion. The excipient was evaluated for its physicochemical properties and then used to formulate tablets with the addition of a disintegrant by direct compression. The tablets were evaluated for their tablet properties and compared with tablets prepared with cellactose- 80® (CEL) and spray dried lactose® (SDL) and a physical mix (PM) of the co-processed ingredient. Results from evaluation of CE showed that flow rate, angle of repose, Carr’s index and Hausner’s ratio were 5.28 g/sec, 20.30o, 23.75 % and 1.31, respectively. Tablets prepared with CE had friability (0%), crushing strength (5.25) KgF, disintegration time (3 mins) and T50% (2 mins). For CEL, friability (0.4 %), crushing strength (7.25) KgF, disintegration time (1 min) and T50% (2 mins); SDL, friability (1.57 %), crushing strength (7.50) KgF, disintegration time (4 mins) and T50% (2 mins) and PM, friability (2.38 %), crushing strength (5.00) KgF, disintegration time (1 min) and T50% (2 mins). In conclusion, the disintegration time and drug release profile for CE was not superior but compared favorably with CEL, SDL and PM.  

Effect of DMSO on micellization, gelation and drug release profile of Poloxamer 407

2010 ◽  
Vol 394 (1-2) ◽  
pp. 92-98 ◽  
Author(s):  
Tofeeq Ur-Rehman ◽  
Staffan Tavelin ◽  
Gerhard Gröbner
Keyword(s):  
Drug Release ◽  
Release Profile ◽  
Poloxamer 407 ◽  
Drug Release Profile

DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE PATCHES OF NICERGOLINE FOR BUCCAL DRUG DELIVERY BY USING FACTORIAL DESIGN OF EXPERIMENT (DOE)

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (07) ◽  
pp. 52-57
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Design Of Experiment ◽  
Release Profile ◽  
Drug Release Profile ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Drug Content ◽  
Release Study

The aim of this research was to develop mucoadhesive buccal patches of nicergoline by using Factorial Design of Experiment, in order to provide a sustained release of drug into the systemic circulation. A 33 factorial experimental design was employed for optimization and to study the effect of formulation variables on responses R1 (% swelling index), R2 (% drug content), R3 (mucoadhesion time) and R4 (mucoadhesion strength). In vitro drug release study was performed on the optimized formulations. All the prepared formulations had good mechanical strength, mucoadhesion strength, neutral surface pH and drug content up to 98.17%. In vitro drug release study revealed that F-5 formulation showed promising sustained drug release profile (98.21%) for over 8 h and could be a potential substitute for marketed conventional formulations. The developed formulation (F5) was found to be optimized with considerably good stability and extended drug release profile.

scholarly journals Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation

2017 ◽  
Vol 2017 ◽  
pp. 1-12
Author(s):  
Abdul Karim ◽  
Muhammad Ashraf Shaheen ◽  
Tahir Mehmood ◽  
Abdul Rauf Raza ◽  
Musadiq Aziz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Lag Time ◽  
Zero Order ◽  
Release Profile ◽  
Drug Release Profile ◽  
Independent Variables ◽  
Zero Order Kinetics ◽  
Model Drug ◽  
Predicted Values

The float formulation is a strategy to improve the bioavailability of drugs by gastroretentive drug delivery system (GRDDS). A drug delivery model based on swellable and reswellable low density biopolymers has been designed to evaluate its drug release profile using ranitidine (RNT) as a model drug and formulations have been prepared utilizing 32factorial designs. The drug release (DR) data has been subjected to various kinetic models to investigate the DR mechanism. A reduction in rate has been observed by expanding the amounts of PSG and LSG parts, while an expansion has been noted by increasing the concentration of tragacanth (TG) and citric acid (CA) with an increment in floating time. The stearic acid (SA) has been used to decrease the lag time because a decrease in density of system was observed. The kinetic analysis showed that the optimized formulation (S4F3) followed zero-order kinetics and power law was found to be best fitted due to its minimum lag time and maximum floating ability. The resemblance of observed and predicted values indicated the validity of derived equations for evaluating the effect of independent variables while kinetic study demonstrated that the applied models are feasible for evaluating and developing float for RNT.

Sign in / Sign up

Export Citation Format

Share Document