Point-of-care testing of melamine via gas pressure readout using polythymine-coated Au@Pt nanoparticles through specific triple hydrogen-bonding recognition

The Analyst ◽  
2021 ◽  
Author(s):  
Ling Li ◽  
Hanwen Deng ◽  
Zhongshuai Zhao ◽  
Zhongde Liu
Keyword(s):  
Hydrogen Bonding ◽  
Point Of Care ◽  
Pt Nanoparticles ◽  
Gas Pressure ◽  
Point Of Care Testing ◽  
Highly Sensitive

On the basis of the target-responsive aggregation occurrence of Au@PtNPs, a pressure-based signaling strategy was developed for highly sensitive and specific melamine detection not only in laboratory but also in point-of-care (POC) settings.

Paper-based selective and quantitative detection of uric acid using citrate-capped Pt nanoparticles (PtNPs) as a colorimetric sensing probe through a simple and remote-based device

2019 ◽  
Vol 43 (20) ◽  
pp. 7636-7645 ◽  
Author(s):  
Muhsin Ali ◽  
Muhammad Asad Ullah Khalid ◽  
Imran Shah ◽  
Soo Wan Kim ◽  
Young Su Kim ◽  
...  
Keyword(s):  
Uric Acid ◽  
Point Of Care ◽  
Pt Nanoparticles ◽  
Quantitative Detection ◽  
Point Of Care Testing ◽  
Colorimetric Sensing

A colorimetric portable setup was developed for remote UA measurements using a smartphone-based application to demonstrate its use in point-of-care testing.

A Shake&Read distance-based microfluidic chip as a portable quantitative readout device for highly sensitive point-of-care testing

2016 ◽  
Vol 52 (91) ◽  
pp. 13377-13380 ◽  
Author(s):  
Yi Xie ◽  
Xiaofeng Wei ◽  
Qizhen Yang ◽  
Zhichao Guan ◽  
Dan Liu ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Point Of Care ◽  
Point Of Care Testing ◽  
Readout Device ◽  
Highly Sensitive ◽  
Disposable Equipment

We developed a Shake&Read distance-based microfluidic chip for simple, disposable, equipment-free, visual and quantitative POCT.

scholarly journals A low-cost smartphone-based platform for highly sensitive point-of-care testing with persistent luminescent phosphors

Lab on a Chip ◽  
2017 ◽  
Vol 17 (6) ◽  
pp. 1051-1059 ◽  
Author(s):  
Andrew S. Paterson ◽  
Balakrishnan Raja ◽  
Vinay Mandadi ◽  
Blane Townsend ◽  
Miles Lee ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Test Strip ◽  
Lateral Flow ◽  
Point Of Care Testing ◽  
Flow Test ◽  
Highly Sensitive ◽  
Lateral Flow Test ◽  
Gated Imaging

Time-gated imaging on a smartphone of a lateral flow test strip run with persistent luminescent nanophosphors.

scholarly journals Recent Advances in Novel Lateral Flow Technologies for Detection of COVID-19

Biosensors ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 295
Author(s):  
Wesley Wei-Wen Hsiao ◽  
Trong-Nghia Le ◽  
Dinh Minh Pham ◽  
Hui-Hsin Ko ◽  
Huan-Cheng Chang ◽  
...  
Keyword(s):  
Point Of Care ◽  
Lateral Flow ◽  
Enzyme Linked Immunosorbent Assay ◽  
Laboratory Diagnostics ◽  
Rt Pcr ◽  
Point Of Care Testing ◽  
Specific Point ◽  
Recent Advances ◽  
Highly Sensitive ◽  
Polymerase Chain

The development of reliable and robust diagnostic tests is one of the most efficient methods to limit the spread of coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, most laboratory diagnostics for COVID-19, such as enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase-polymerase chain reaction (RT-PCR), are expensive, time-consuming, and require highly trained professional operators. On the other hand, the lateral flow immunoassay (LFIA) is a simpler, cheaper device that can be operated by unskilled personnel easily. Unfortunately, the current technique has some limitations, mainly inaccuracy in detection. This review article aims to highlight recent advances in novel lateral flow technologies for detecting SARS-CoV-2 as well as innovative approaches to achieve highly sensitive and specific point-of-care testing. Lastly, we discuss future perspectives on how smartphones and Artificial Intelligence (AI) can be integrated to revolutionize disease detection as well as disease control and surveillance.

Gas pressure-assisted ratiometric atomic flame assay for point-of-care testing of tumor cell-derived exosomes

The Analyst ◽  
2021 ◽  
Author(s):  
Shengqiang Hu ◽  
Xue ting Fang ◽  
Guijing Liu ◽  
Guixiang Ma ◽  
Fanggui Ye ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tumor Cell ◽  
Point Of Care ◽  
Resonance Energy ◽  
Gas Pressure ◽  
Point Of Care Testing ◽  
Vital Importance ◽  
Fluorescence Resonance ◽  
Tumor Growth And Metastasis

Multicolor-based point-of-care testing (POCT) of tumor cell-derived exosomes is of vital importance for understanding tumor growth and metastasis. Multicolor-based ratiometric signals focused on molecular optics, such as fluorescence resonance energy...

Reusable and highly sensitive SERS immunoassay utilizing gold nanostars and a cellulose hydrogel-based platform

2021 ◽  
Author(s):  
Maria João Oliveira ◽  
Inês Cunha ◽  
Miguel Peixoto de Almeida ◽  
Tomás Calmeiro ◽  
Elvira Fortunato ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Point Of Care ◽  
Improve Patient Care ◽  
Point Of Care Testing ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Cellulose Hydrogel ◽  
Enhanced Raman Scattering ◽  
Improve Patient

The development of robust and sensitive point-of-care testing platforms is necessary to improve patient care and outcomes. Surface-Enhanced Raman Scattering (SERS)-based immunosensors are especially suited for this purpose. Here, we...

scholarly journals Mxene-Assisted Organic Electrochemical Transistor Biosensor With Multiple Spiral Interdigitated Electrodes for Sensitive Determination of fPSA/tPSA.

2021 ◽  
Author(s):  
Yi-Cheng Zhu ◽  
Biao Cai ◽  
Quan Jiang ◽  
Yuan Zhang ◽  
Jianjun Sha ◽  
...  
Keyword(s):  
Point Of Care ◽  
Area Under The Curve ◽  
Grey Zone ◽  
Point Of Care Testing ◽  
Highly Sensitive ◽  
Electrochemical Transistor ◽  
Potential Applications ◽  
Sensitive Determination ◽  
Auc Value

Abstract Background: The ratio of fPSA/tPSA in the “grey zone” of tPSA with the concentration range between 4 ng/ml and 10 ng/ml is significant for diagnosis of prostate cancer, and highly efficiency quantification of the ratio of fPSA/tPSA remain elusive mainly because of their extremely low concentration in patients’ peripheral blood with high biosample complexity.Methods: We presented an interdigitated spiral-based MXene-assisted organic electrochemical transistors (isMOECTs) biosensor for highly sensitive determination of fPSA/tPSA. The combination of MXene and the interdigitated multiple spiral architecture synergistically assisted the amplification of amperometric signal of biosensor with dual functionalizations of anti-tPSA and anti-fPSA.Results: The ultrasensitivity of the biosensor was enhanced by tunable multiple spiral architecture and MXene nanomaterials; and the sensor demonstrated enhanced detection limit of tPSA and fPSA down to 0.01 pg/ml, as well as satisfactory selectivity, reproducibility and reliability, which was comparable to the best previous literatures; Moreover, the isMOECTs displayed area under the curve (AUC) value of 0.8138, confirming the potential applications of isMOECTs in clinics.Conclusions: The merits of isMOECTs biosensor demonstrated the reliability of MXene-assisted organic electrochemical transistor biosensor with multiple interdigitated spiral for ultrasensitive quantification of fPSA/tPSA, suggesting potential current and future point-of-care testing applications.

scholarly journals MXene-assisted organic electrochemical transistor biosensor with multiple spiral interdigitated electrodes for sensitive quantification of fPSA/tPSA

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yi-Cheng Zhu ◽  
Biao Cai ◽  
Quan Jiang ◽  
Yuan Zhang ◽  
Jianjun Sha ◽  
...  
Keyword(s):  
Point Of Care ◽  
Area Under The Curve ◽  
Grey Zone ◽  
Point Of Care Testing ◽  
Highly Sensitive ◽  
Electrochemical Transistor ◽  
Potential Applications ◽  
Sensitive Determination ◽  
Auc Value

Abstract Background The ratio of fPSA/tPSA in the "grey zone" of tPSA with the concentration range between 4 ng/ml and 10 ng/ml is significant for diagnosis of prostate cancer, and highly efficiency quantification of the ratio of fPSA/tPSA remain elusive mainly because of their extremely low concentration in patients' peripheral blood with high biosample complexity. Methods We presented an interdigitated spiral-based MXene-assisted organic electrochemical transistors (isMOECTs) biosensor for highly sensitive determination of fPSA/tPSA. The combination of MXene and the interdigitated multiple spiral architecture synergistically assisted the amplification of amperometric signal of biosensor with dual functionalizations of anti-tPSA and anti-fPSA. Results The ultrasensitivity of the biosensor was enhanced by tunable multiple spiral architecture and MXene nanomaterials; and the sensor exhibited improved detection limit of tPSA and fPSA down to 0.01 pg/ml and acceptable performance of selectivity, repeatability and stability. Moreover, the isMOECTs displayed area under the curve (AUC) value of 0.8138, confirming the potential applications of isMOECTs in clinics. Conclusions The merits of isMOECTs biosensor demonstrated the reliability of MXene-assisted organic electrochemical transistor biosensor with multiple interdigitated spiral for ultrasensitive quantification of fPSA/tPSA, suggesting potential current and future point-of-care testing applications. Graphical Abstract

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