Melanin pigments extracted from horsehair as antibacterial agents

2021 ◽  
Author(s):  
Tahmineh Rahmani Eliato ◽  
Joshua T. Smith ◽  
Zhen Tian ◽  
Eun-Sik Kim ◽  
Wonseok Hwang ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Potential Use

Here we present the important findings related to biologically derived pigments for potential use as antibacterial agents.

Harvesting greenish blue luminescence in gold(i) complexes and their application as promising bioactive molecules and cellular bioimaging agents

2020 ◽  
Vol 44 (17) ◽  
pp. 6862-6871
Author(s):  
Lis R. V. Favarin ◽  
G. B. Laranjeira ◽  
Cristiane F. A. Teixeira ◽  
Heveline Silva ◽  
A. C. Micheletti ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Bioactive Molecules ◽  
Blue Luminescence ◽  
Luminescent Probes ◽  
Greenish Blue ◽  
Potential Use

This work presents new gold materials as promising antitumoral and antibacterial agents and their potential use as luminescent probes for cellular bioimaging.

scholarly journals Repurposing Thiram and Disulfiram as Antibacterial Agents for Multidrug-Resistant Staphylococcus aureus Infections

2017 ◽  
Vol 61 (9) ◽  
Author(s):  
Timothy E. Long
Keyword(s):  
Staphylococcus Aureus ◽  
Combination Therapy ◽  
Antibacterial Agents ◽  
Multidrug Resistant ◽  
Positive Bacterium ◽  
Content Type ◽  
Spectrum Activity ◽  
Vancomycin Resistant ◽  
Potential Use

ABSTRACT Thiram and disulfiram were evaluated as antibacterial agents against multidrug-resistant Staphylococcus aureus. Against a 30-member panel comprised of vancomycin-susceptible, vancomycin-intermediate, and vancomycin-resistant S. aureus strains, the MIC90 values of the respective test agents were 4 and 16 μg/ml. Additional analyses revealed that thiram and disulfiram are rapid-acting bacteriostatic agents with narrow, Gram-positive-bacterium spectrum activity. Synergy studies further determined that disulfiram increases the vancomycin susceptibility of three clinical vancomycin-resistant S. aureus strains in vitro, thus establishing a potential use in combination therapy.

Colicin M, a peptidoglycan lipid-II-degrading enzyme: potential use for antibacterial means?

2012 ◽  
Vol 40 (6) ◽  
pp. 1522-1527 ◽  
Author(s):  
Thierry Touzé ◽  
Hélène Barreteau ◽  
Meriem El Ghachi ◽  
Ahmed Bouhss ◽  
Aurélie Barnéoud-Arnoulet ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Catalytic Domain ◽  
Cell Integrity ◽  
Active Site Residues ◽  
Isomerase Activity ◽  
Lipid Ii ◽  
Genes Encoding ◽  
Colicin M ◽  
Potential Use

Colicins are proteins produced by some strains of Escherichia coli to kill competitors belonging to the same species. Among them, ColM (colicin M) is the only one that blocks the biosynthesis of peptidoglycan, a specific bacterial cell-wall polymer essential for cell integrity. ColM acts in the periplasm by hydrolysing the phosphoester bond of the peptidoglycan lipid intermediate (lipid II). ColM cytotoxicity is dependent on FkpA of the targeted cell, a chaperone with peptidylprolyl cis–trans isomerase activity. Dissection of ColM was used to delineate the catalytic domain and to identify the active-site residues. The in vitro activity of the isolated catalytic domain towards lipid II was 50-fold higher than that of the full-length bacteriocin. Moreover, this domain was bactericidal in the absence of FkpA under conditions that bypass the import mechanism (FhuA–TonB machinery). Thus ColM undergoes a maturation process driven by FkpA that is not required for the activity of the isolated catalytic domain. Genes encoding proteins with similarity to the catalytic domain of ColM were identified in pathogenic strains of Pseudomonas and other genera. ColM acts on several structures of lipid II representative of the diversity of peptidoglycan chemotypes. All together, these data open the way to the potential use of ColM-related bacteriocins as broad spectrum antibacterial agents.

Fluorescent lactose-derived catanionic aggregates: synthesis, characterisation and potential use as antibacterial agents

RSC Advances ◽  
2016 ◽  
Vol 6 (28) ◽  
pp. 23340-23344
Author(s):  
Alexandre Bettoschi ◽  
Alain Brisson ◽  
Claudia Caltagirone ◽  
Angela M. Falchi ◽  
Francesco Isaia ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Low Cost ◽  
Antibacterial Properties ◽  
Drug Resistant ◽  
Gram Positive ◽  
Organic Salts ◽  
Gram Positive Bacteria ◽  
Catanionic Surfactants ◽  
Potential Use

The antibacterial properties of catanionic surfactants based on fluorescent lactose-derivative organic salts using low-cost starting materials were investigated towards multi-drug-resistant Gram-positive bacteria.

scholarly journals Systematic discovery of pseudomonad genetic factors involved in sensitivity to tailocins

2021 ◽  
Author(s):  
Sean Carim ◽  
Ashley L. Azadeh ◽  
Alexey E. Kazakov ◽  
Morgan N. Price ◽  
Peter J. Walian ◽  
...  
Keyword(s):  
Community Structure ◽  
Microbial Community ◽  
Antibacterial Agents ◽  
Genetic Factors ◽  
Protein Complexes ◽  
High Specificity ◽  
Genome Wide ◽  
Resistant Strains ◽  
Morphological Relationship ◽  
Potential Use

AbstractTailocins are bactericidal protein complexes produced by a wide variety of bacteria that kill closely related strains and may play a role in microbial community structure. Thanks to their high specificity, tailocins have been proposed as precision antibacterial agents for therapeutic applications. Compared to tailed phages, with whom they share an evolutionary and morphological relationship, bacterially produced tailocins kill their host upon production but producing strains display resistance to self-intoxication. Though lipopolysaccharide (LPS) has been shown to act as a receptor for tailocins, the breadth of factors involved in tailocin sensitivity, and the mechanisms behind resistance to self-intoxication, remain unclear. Here, we employed genome-wide screens in four non-model pseudomonads to identify mutants with altered fitness in the presence of tailocins produced by closely related pseudomonads. Our mutant screens identified O-antigen composition and display as most important in defining sensitivity to our tailocins. In addition, the screens suggest LPS thinning as a mechanism by which resistant strains can become more sensitive to tailocins. We validate many of these novel findings, and extend these observations of tailocin sensitivity to 130 genome-sequenced pseudomonads. This work offers insights into tailocin–bacteria interactions, informing the potential use of tailocins in microbiome manipulation and antibacterial therapy.

The growth of mica polytypes as studied by conventional and high-resolution TEM

1983 ◽  
Vol 41 ◽  
pp. 174-177
Author(s):  
A. Baronnet ◽  
M. Amouric
Keyword(s):  
Water Pressure ◽  
Point Of View ◽  
Temperature Fields ◽  
Natural Occurrence ◽  
Growth Mechanisms ◽  
Long Period ◽  
High Resolution Tem ◽  
Layer Stacking ◽  
Experimental Works ◽  
Potential Use

The origin of mica polytypes has long been a challenging problem for crystal- lographers, mineralogists and petrologists. From the petrological point of view, interest in this field arose from the potential use of layer stacking data to furnish further informations about equilibrium and/or kinetic conditions prevailing during the crystallization of the widespread mica-bearing rocks. From the compilation of previous experimental works dealing with the occurrence domains of the various mica "polymorphs" (1Mr, 1M, 2M1, 2M2 and 3T) within water-pressure vs temperature fields, it became clear that most of these modifications should be considered as metastable for a fixed mica species. Furthermore, the natural occurrence of long-period (or complex) polytypes could not be accounted for by phase considerations. This highlighted the need of a more detailed kinetic approach of the problem and, in particular, of the role growth mechanisms of basal faces could play in this crystallographic phenomenon.

An atomic-resolution microscope study of Al contracts on GaAs

1986 ◽  
Vol 44 ◽  
pp. 726-727
Author(s):  
Z. Liliental-Weber ◽  
C. Nelson ◽  
R. Ludeke ◽  
R. Gronsky ◽  
J. Washburn
Keyword(s):  
High Speed ◽  
Schottky Contacts ◽  
Detailed Knowledge ◽  
The Past ◽  
Semiconductor Interfaces ◽  
Deposited Metal ◽  
Microwave Applications ◽  
Free Interfaces ◽  
Potential Use

The properties of metal/semiconductor interfaces have received considerable attention over the past few years, and the Al/GaAs system is of special interest because of its potential use in high-speed logic integrated optics, and microwave applications. For such materials a detailed knowledge of the geometric and electronic structure of the interface is fundamental to an understanding of the electrical properties of the contact. It is well known that the properties of Schottky contacts are established within a few atomic layers of the deposited metal. Therefore surface contamination can play a significant role. A method for fabricating contamination-free interfaces is absolutely necessary for reproducible properties, and molecularbeam epitaxy (MBE) offers such advantages for in-situ metal deposition under UHV conditions

The potential use of short chain peptides in parenteral nutrition

1985 ◽  
Vol 4 ◽  
pp. 116-123 ◽  
Author(s):  
P STEHLE ◽  
S ALBERS ◽  
I AMBERGER ◽  
P PFAENDER ◽  
P FURST
Keyword(s):  
Parenteral Nutrition ◽  
Short Chain ◽  
Potential Use

Dermatitis in pets: Study of Brazilian savannah plants as potential antibacterial agents

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
AC Valle ◽  
L Rabelo ◽  
AL Magalhães ◽  
M Neves ◽  
I Maciel ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Brazilian Savannah
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