Harvesting greenish blue luminescence in gold(i) complexes and their application as promising bioactive molecules and cellular bioimaging agents

2020 ◽  
Vol 44 (17) ◽  
pp. 6862-6871
Author(s):  
Lis R. V. Favarin ◽  
G. B. Laranjeira ◽  
Cristiane F. A. Teixeira ◽  
Heveline Silva ◽  
A. C. Micheletti ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Bioactive Molecules ◽  
Blue Luminescence ◽  
Luminescent Probes ◽  
Greenish Blue ◽  
Potential Use

This work presents new gold materials as promising antitumoral and antibacterial agents and their potential use as luminescent probes for cellular bioimaging.

Nutraceuticals from Marine Bionetworks

2019 ◽  
Vol 15 (4) ◽  
pp. 338-344
Author(s):  
Abhitav Tiwari ◽  
Shambhawi Pritam ◽  
Keerti Mishra ◽  
Mehshara Khan ◽  
Neeraj Upmanyu ◽  
...  
Keyword(s):  
Dietary Supplements ◽  
Bioactive Compounds ◽  
Daily Basis ◽  
Marine Organisms ◽  
Bioactive Molecules ◽  
Natural Sources ◽  
Nutraceutical Compounds ◽  
Potential Sources ◽  
Immense Potential ◽  
Potential Use

“Nutrition” and “Pharmaceutical” together build up the perception of “Nutraceuticals” that refer to the food or dietary supplements that help to incorporate additional health benefits to the fundamental sustenance accomplished on daily basis. Each nutraceutical contains one or more bioactive molecules that are usually obtained by chemical and/ or biotechnological synthesis or by extraction from natural sources. Among the natural sources, marine bionetwork possess immense potential for the presence of bioactive compounds. Some of these bioactive compounds as isolated from marine sources, have potential use as nutraceuticals. This mini review provides a brief overview of nutraceutical compounds from marine sources that are currently under research and/or have been commercialized. A detailed discussion on the biochemical categories of compounds and the marine organisms that play as potential sources of these bioactive nutraceutical compounds have been included.

Kefir peptide (Kef-1) as an emerging approach for the treatment of oxidative stress and inflammation in 2K1C mice

2022 ◽  
Author(s):  
Rafaela Aires ◽  
Fernanda Gobbi Amorim ◽  
Larissa Zambom Côco ◽  
Amanda Pompermayer da Conceição ◽  
Tadeu Ériton Caliman Zanardo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Converting Enzyme ◽  
Ace Inhibitors ◽  
Bioactive Molecules ◽  
Converting Enzyme ◽  
The Rich ◽  
Potential Use

The benefits of Kefir consumption are due, in part, to the rich composition of bioactive molecules released from fermentation. Angiotensin-converting enzyme (ACE) inhibitors are bioactive molecules with potential use in...

Melanin pigments extracted from horsehair as antibacterial agents

2021 ◽  
Author(s):  
Tahmineh Rahmani Eliato ◽  
Joshua T. Smith ◽  
Zhen Tian ◽  
Eun-Sik Kim ◽  
Wonseok Hwang ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Potential Use

Here we present the important findings related to biologically derived pigments for potential use as antibacterial agents.

scholarly journals Nonclassical Biological Activities of Quinolone Derivatives

2011 ◽  
Vol 15 (1) ◽  
pp. 52 ◽  
Author(s):  
Mohsen Daneshtalab ◽  
Abeer Ahmed
Keyword(s):  
Mammalian Cells ◽  
Antibacterial Agents ◽  
Biological Activities ◽  
Antiviral Agent ◽  
Bioactive Molecules ◽  
Structural Modifications ◽  
Further Development ◽  
Derivatives Of ◽  
Ns5b Polymerase

Quinolones are considered as a big family of multi-faceted drugs; their chemical synthesis is flexible and can be easily adapted to prepare new congeners with rationally devised structures. This is shown by the description of many thousands of derivatives in the literature. Scientists could accurately describe their QSAR, which is essential for effective drug design. This also gave them the chance to discover new and unprecedented activities, which makes quinolones an endless source of hope and enables further development of new clinically useful drugs. Quinolones are among the most common frameworks present in the bioactive molecules that have dominated the market for more than four decades. Since 1962, 4(1H)-quinolone-3-carboxylic acid derivatives are widely used as antibacterial agents. Quinolones have a broad and potent spectrum of activity and are also used as second-line drugs to treat tuberculosis (TB). Recently, quinolones have been reported to display “nonclassical” biological activities, such as antitumor, anti-HIV-1 integrase, anti- HCV-NS3 helicase and -NS5B-polymerase activities. The present review focuses on the structural modifications responsible for the transformation of an antibacterial into an anticancer agent and/or an antiviral agent. Indeed, quinolones’ antimicrobial action is distinguishable among antibacterial agents, because they target different type II topoisomerase enzymes. Many derivatives of this family show high activity against bacterial topoisomerases and eukaryotic topoisomerases, and are also toxic to cultured mammalian cells and in vivo tumor models. Moreover, quinolones have shown antiviral activity against HIV and HCV viruses. In this context the quinolones family of drugs seem to link three different biological activities (antibacterial, anticancer, and the antiviral profiles) and the review will also provide an insight into the different mechanisms responsible for these activities among different species. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Extracellular Vesicles as Biological Shuttles for Targeted Therapies

2019 ◽  
Vol 20 (8) ◽  
pp. 1848 ◽  
Author(s):  
Stefania Raimondo ◽  
Gianluca Giavaresi ◽  
Aurelio Lorico ◽  
Riccardo Alessandro
Keyword(s):  
Extracellular Vesicles ◽  
Therapeutic Agents ◽  
Bioactive Molecules ◽  
Target Cells ◽  
Special Focus ◽  
Pathological Conditions ◽  
Critical Issues ◽  
Membrane Bound ◽  
And Function ◽  
Potential Use

The development of effective nanosystems for drug delivery represents a key challenge for the improvement of most current anticancer therapies. Recent progress in the understanding of structure and function of extracellular vesicles (EVs)—specialized membrane-bound nanocarriers for intercellular communication—suggests that they might also serve as optimal delivery systems of therapeutics. In addition to carrying proteins, lipids, DNA and different forms of RNAs, EVs can be engineered to deliver specific bioactive molecules to target cells. Exploitation of their molecular composition and physical properties, together with improvement in bio-techniques to modify their content are critical issues to target them to specific cells/tissues/organs. Here, we will discuss the current developments in the field of animal and plant-derived EVs toward their potential use for delivery of therapeutic agents in different pathological conditions, with a special focus on cancer.

Evaluation of Anti-inflammatory, Antinociceptive, and Antipyretic Activities of Prunus persica var. nucipersica (Nectarine) Kernel

Planta Medica ◽  
2019 ◽  
Vol 85 (11/12) ◽  
pp. 1016-1023 ◽  
Author(s):  
Abdelsamed Ibrahim Elshamy ◽  
Heba Mohammed Ibrahim Abdallah ◽  
Abd El-Nasser Gaber El Gendy ◽  
Walla El-Kashak ◽  
Beatrice Muscatello ◽  
...  
Keyword(s):  
Nutritional Value ◽  
Prunus Persica ◽  
Phenolic Content ◽  
Bioactive Molecules ◽  
Control Group ◽  
Alcoholic Extract ◽  
Phenolic Constituents ◽  
Anti Inflammatory ◽  
Promising Source ◽  
Potential Use

AbstractNectarine (Prunus persica var. nucipersica) is a worldwide appreciated edible subspecies, with a high nutritional value and benefits on human health due to its phenolic content. Despite the large consumption of the fruit, the potential use of its kernel is poorly studied. Herein, the potential pharmacological activities and the phenolic constituents of an alcoholic extract of kernel nectarine fruits were investigated. Administering nectarine kernel extract (50 and 100 mg/kg, respectively) in rats reduced paw edema after carrageenan injection by 11 and 47% in 1 h, 24 and 33% in 2 h, and 23 and 32% in 4 h, when compared to the controls. At the higher dose (100 mg/kg), nectarine kernel extract increased the reaction time in the hot-plate model and produced a significant decrease in the rectal temperature of the pyretic rats, while both doses produced 52 and 59% of writhing inhibition compared to the control group. Total polyphenolic (55.91 ± 5.78 mg/g) and flavonoid (29.89 ± 0.55 mg/g) content indicated that the extract is a promising source of these constituents. HPLC-ESI-MS/MS analysis demonstrated the presence of flavonoids, such as naringenin and apigenin glycosides. The cyanogenic glycosides amigdalin and prunasin were also detected. These results highlight the anti-inflammatory, analgesic, and antipyretic activities of nectarine kernel alcoholic extract, together with significant phenolic content, promoting its exploitation as a source of bioactive molecules.

scholarly journals Protective Action of Ostreococcus Tauri and Phaeodactylum Tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells

Marine Drugs ◽  
2019 ◽  
Vol 18 (1) ◽  
pp. 3
Author(s):  
Manon Le Goff ◽  
Antoine Delbrut ◽  
Marie Quinton ◽  
Rémi Pradelles ◽  
Maelle Bescher ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Phaeodactylum Tricornutum ◽  
Protective Action ◽  
Environmental Pollutant ◽  
Bioactive Molecules ◽  
Aromatic Hydrocarbon Receptor ◽  
Ostreococcus Tauri ◽  
Polycyclic Aromatic ◽  
Potential Use

Marine microalgae are known to be a source of bioactive molecules of interest to human health, such as n-3 polyunsaturated fatty acids (n-3 PUFAs) and carotenoids. The fact that some of these natural compounds are known to exhibit anti-inflammatory, antioxidant, anti-proliferative, and apoptosis-inducing effects, demonstrates their potential use in preventing cancers and cardiovascular diseases (CVDs). Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon (PAH), is an ubiquitous environmental pollutant known to contribute to the development or aggravation of human diseases, such as cancer, CVDs, and immune dysfunction. Most of these deleterious effects are related to the activation of the polycyclic aromatic hydrocarbon receptor (AhR). In this context, two ethanolic microalgal extracts with concentrations of 0.1 to 5 µg/mL are tested, Ostreoccoccus tauri (OT) and Phaeodactylum tricornutum (PT), in order to evaluate and compare their potential effects towards B[a]P-induced toxicity in endothelial HMEC-1 cells. Our results indicate that the OT extract can influence the toxicity of B[a]P. Indeed, apoptosis and the production of extracellular vesicles were decreased, likely through the reduction of the expression of CYP1A1, a B[a]P bioactivation enzyme. Furthermore, the B[a]P-induced expression of the inflammatory cytokines IL-8 and IL1-β was reduced. The PT extract only inhibited the expression of the B[a]P-induced cytokine IL-8 expression. The OT extract therefore seems to be a good candidate for counteracting the B[a]P toxicity.

3D-QSAR CoMFA Studies on Benzenesulfonamides with Benzimidazole Moieties as Inhibitors of Carbonic Anhydrases XII as Antitumor Agents

2019 ◽  
Vol 15 (1) ◽  
pp. 69-77
Author(s):  
Shalini Singh
Keyword(s):  
Carbonic Anhydrase ◽  
Antitumor Agents ◽  
3D Qsar ◽  
Research Area ◽  
Bioactive Molecules ◽  
Steric Effects ◽  
Carbonic Anhydrases ◽  
Significant Research ◽  
Potential Use ◽  
Structural Aspects

Introduction: In recent times, a new very significant research area has developed and obtained the potential use of Carbonic Anhydrase inhibitors as Antitumor agents. Methods: A series of sulfonamides and Benzenesulfonamides with benzimidazole moieties to inhibit CSXII was considered in this study. Results and Conclusion: The best model was obtained with a predictive r2 value of 0.678 and cross validated coefficient q2 value as 0.529 in tripos CoMFA region. The paper shows that the electrostatic and steric effects are important features in Carbonic Anhydrase XII inhibition for the investigated compounds. The effort has been undertaken to search for the structural aspects of bioactive molecules.

Bioactive compounds from bay leaves (Laurus nobilis) extracted by microwave technology

2018 ◽  
Vol 73 (9-10) ◽  
pp. 401-407 ◽  
Author(s):  
Diana B. Muñiz-Márquez ◽  
Jorge E. Wong-Paz ◽  
Juan C. Contreras-Esquivel ◽  
Raúl Rodríguez-Herrera ◽  
Cristóbal N. Aguilar
Keyword(s):  
Bioactive Compounds ◽  
Aqueous Ethanol ◽  
Irradiation Time ◽  
Biological Properties ◽  
Bioactive Molecules ◽  
Total Phenolic ◽  
Laurus Nobilis ◽  
Assisted Extraction ◽  
Gallic Acid Equivalent ◽  
Potential Use

Abstract Laurus nobilis leaves contain flavored and bioactive components with relevant biological properties for human health that are attributed to an abundant presence of highly bioactive secondary metabolites. However, the separation process for these bioactive molecules from plant matrix is seriously limited by the presence of a physical barrier (cell wall). Thus, the use of novel extraction procedures to enhance their release is particularly important. In this work, the potential use of microwave-assisted extraction (MAE) as a tool to improve the extraction efficiency of bioactive compounds from bay leaves and their characterization was evaluated. The effects of irradiation time (3, 6 and 9 min) and aqueous ethanol concentration (0, 25 and 50%) on the extraction of phenolic compounds were evaluated. A response surface methodology was applied to determine the best extraction conditions by MAE. The maximum total phenolic compound under the best conditions (9 min time irradiation and aqueous ethanol 50%) was 10.63±0.91 mg gallic acid equivalent/g plant using MAE. Also, the antioxidant potential of the extracts obtained was evaluated.

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