scholarly journals Amino acid-modified PAMAM dendritic nanocarriers as effective chemotherapeutic drug vehicles in cancer treatment: a study using zebrafish as a cancer model

RSC Advances ◽  
2020 ◽  
Vol 10 (35) ◽  
pp. 20682-20690 ◽  
Author(s):  
Szu-Yuan Wu ◽  
Hsiao-Ying Chou ◽  
Hsieh-Chih Tsai ◽  
Rajeshkumar Anbazhagan ◽  
Chiou-Hwa Yuh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Amino Acid ◽  
Controlled Release ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Chemotherapeutic Drug ◽  
Cancer Model

The use of nanomaterials for drug delivery offers many advantages including the controlled release and their targeted delivery.

scholarly journals Targeted Delivery of Narrow-Spectrum Protein Antibiotics to the Lower Gastrointestinal Tract in a Murine Model of Escherichia coli Colonization

2021 ◽  
Vol 12 ◽  
Author(s):  
Nuria Carpena ◽  
Kerry Richards ◽  
Teresita D. J. Bello Gonzalez ◽  
Alberto Bravo-Blas ◽  
Nicholas G. Housden ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Drug Delivery ◽  
Controlled Release ◽  
Animal Models ◽  
Targeted Delivery ◽  
Intestinal Colonization ◽  
Ph Responsive ◽  
Human Gut ◽  
E Coli

Bacteriocins are narrow-spectrum protein antibiotics that could potentially be used to engineer the human gut microbiota. However, technologies for targeted delivery of proteins to the lower gastrointestinal (GI) tract in preclinical animal models are currently lacking. In this work, we have developed methods for the microencapsulation of Escherichia coli targeting bacteriocins, colicin E9 and Ia, in a pH responsive formulation to allow their targeted delivery and controlled release in an in vivo murine model of E. coli colonization. Membrane emulsification was used to produce a water-in-oil emulsion with the water-soluble polymer subsequently cross-linked to produce hydrogel microcapsules. The microcapsule fabrication process allowed control of the size of the drug delivery system and a near 100% yield of the encapsulated therapeutic cargo. pH-triggered release of the encapsulated colicins was achieved using a widely available pH-responsive anionic copolymer in combination with alginate biopolymers. In vivo experiments using a murine E. coli intestinal colonization model demonstrated that oral delivery of the encapsulated colicins resulted in a significant decrease in intestinal colonization and reduction in E. coli shedding in the feces of the animals. Employing controlled release drug delivery systems such as that described here is essential to enable delivery of new protein therapeutics or other biological interventions for testing within small animal models of infection. Such approaches may have considerable value for the future development of strategies to engineer the human gut microbiota, which is central to health and disease.

Formulation and clinical perspectives of inhalation-based nanocarrier delivery: a new archetype in lung cancer treatment

2021 ◽  
Vol 12 (5) ◽  
pp. 397-418
Author(s):  
Denish Bardoliwala ◽  
Ankit Javia ◽  
Saikat Ghosh ◽  
Ambikanandan Misra ◽  
Krutika Sawant
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Cancer Therapeutics ◽  
High Dose ◽  
Lung Cancer Treatment ◽  
Inhalation Delivery ◽  
Lung Cancer Therapy ◽  
Core Part

Despite tremendous research in targeted delivery and specific molecular inhibitors (gene delivery), cytotoxic drug delivery through inhalation has been seen as a core part in the treatment of the lung cancer. Inhalation delivery provides a high dose of the drug directly to the lungs without affecting other body organs, increasing the therapeutic ratio. This article reviews the research performed over the last several decades regarding inhalation delivery of various cancer therapeutics for the treatment of lung cancer. Nevertheless, pulmonary administration of nanocarrier-based cancer therapeutics for lung cancer therapy is still in its infancy and faces greater than expected challenges. This article focuses on the current inhalable nanocarrier-based drugs for lung cancer treatment.

Amphiphilic designer nano-carriers for controlled release: from drug delivery to diagnostics

MedChemComm ◽  
2014 ◽  
Vol 5 (11) ◽  
pp. 1602-1618 ◽  
Author(s):  
Malinda Salim ◽  
Hiroyuki Minamikawa ◽  
Akihiko Sugimura ◽  
Rauzah Hashim
Keyword(s):  
Drug Delivery ◽  
Liquid Crystal ◽  
Controlled Release ◽  
Targeted Delivery ◽  
Design Considerations

Our review highlights lipid liquid crystal nanocarriers, essentially their design considerations and sugar-based materials for specific targeted delivery.

IRON OXIDE MAGNETIC NANOPARTICLES AS DRUG DELIVERY SYSTEMS FOR BRAIN CANCER TREATMENT

2021 ◽  
Vol 2 (1) ◽  
pp. 55-66
Author(s):  
Oana Stefana Purcaru ◽  
Alexandra Costachi ◽  
Catalina Elena Cioc ◽  
Alice Buteica ◽  
Anica Dricu
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
High Grade Glioma ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Vitro Effect

Nanotechnology offers a new horizon for cancer drug administration and systemic safety of oncological treatments. Compared with conventional pharmaceutical forms, nanoparticles (NPs) have many advantages such as larger surface, ability to adsorb and targeted delivery of different types of drugs, providing decreased side effects and a patient customed approach in cancer treatment. Due to their diverse chemical composition, NPs offer the possibility of developing innovative therapies, which may be also applied in glioblastoma treatment. Fe3O4 magnetic nanoparticles (MNPs) have been previously used in cancer treatment, as targeted drug delivery systems. Helianthin is an azo dye compound that we found to induce cell death in high grade glioma (HGG) cells. In this study, we analyzed the in vitro effect of MNPs loaded with Helianthin (HeMNPs) on a glioblastoma cell line (GB2B).

Controlled release and targeted delivery to cancer cells of doxorubicin from polysaccharide-functionalised single-walled carbon nanotubes

2015 ◽  
Vol 3 (9) ◽  
pp. 1846-1855 ◽  
Author(s):  
Yunfei Mo ◽  
Haowen Wang ◽  
Jianghui Liu ◽  
Yong Lan ◽  
Rui Guo ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Water Solubility ◽  
Single Walled Carbon Nanotubes ◽  
Innovative Drug ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Carboxyl single-walled carbon nanotubes (SWNTs) were used to construct an innovative drug delivery system by modification with chitosan (CHI) to enhance water solubility and biocompatibility.

scholarly journals Polydopamine Modified Superparamagnetic Iron Oxide Nanoparticles as Multifunctional Nanocarrier for Targeted Prostate Cancer Treatment

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 138 ◽  
Author(s):  
Nimisha Singh ◽  
Fadoua Sallem ◽  
Celine Mirjolet ◽  
Thomas Nury ◽  
Suban Kumar Sahoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photoelectron Spectroscopy ◽  
Targeted Delivery ◽  
Easy Access ◽  
Shell Nanoparticles ◽  
Vis Spectroscopy

Polydopamine (pDA)-modified iron oxide core-shell nanoparticles (IONPs) are developed and designed as nanovectors of drugs. Reactive quinone of pDA enhances the binding efficiency of various biomolecules for targeted delivery. Glutathione disulfide (GSSG), an abundant thiol species in the cytoplasm, was immobilized on the pDA-IONP surface. It serves as a cellular trigger to release the drug from the nanoparticles providing an efficient platform for the drug delivery system. Additionally, GSSG on the surface was further modified to form S-nitrosoglutathione that can act as nitric oxide (NO) donors. These NPs were fully characterized using a transmission electronic microscopy (TEM), thermogravimetric analysis (TGA), dynamic light scattering (DLS), zeta potential, X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) and UV-vis spectroscopies. Doxorubicin (DOX) and docetaxel (DTX) are two anticancer drugs, which were loaded onto nanoparticles with respective loading efficiencies of 243 and 223 µmol/g of IONPs, calculated using TGA measurements. DOX release study, using UV-vis spectroscopy, showed a pH responsive behavior, making the elaborated nanocarrier a potential drug delivery system. (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl) -2H-tetrazolium (MTS) and apoptosis assays were performed on PC3 cell lines to evaluate the efficiency of the developed nanocarriers. These nanoparticles thus can prove their worth in cancer treatment on account of their easy access to the site and release of drug in response to changes to internal parameters such as pH, chemicals, etc.

scholarly journals Formulation Development, Characterization and In-vitro Evaluation of Tamoxifen Loaded Liposomes

2020 ◽  
pp. 64-82
Author(s):  
Md. Mazed Hasan ◽  
Md. Hamiduzzaman ◽  
Ishrat Jahan ◽  
A. H. M. Nazmul Hasan ◽  
Md. Asaduzzaman
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Side Effects ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ex Vivo ◽  
Release Kinetics ◽  
Formulation Development

Background: The study was aimed to prepare and evaluate tamoxifen loaded controlled release liposomes to reduce the side effects of tamoxifen during cancer treatment.  Methods: Different tamoxifen loaded liposomes were prepared by modified ether injection (MEIM) and thin film hydration method (TFHM) under prescribed conditions. The prepared liposomes were characterized by using optical microscopy, evaluating encapsulation efficiency, in-vitro and ex-vivo diffusion studies by using dialysis membrane and chicken intestinal sac respectively. Results: The data revealed that all of the liposomes were spherical in shape and stable under three physical conditions i.e. 4, 25 and 37 ± 2°C temperatures and 60 ±5% relative humidity. Additionally most of the liposomes followed zero order and class II release kinetics. It was also observed that with the increase of phospholipids and cholesterol, entrapment efficiency of liposome vesicles increased thus giving a controlled release drug delivery system but further increase reduced this efficiency at a certain level. Conclusion: The formulated control release liposomes might be a good drug delivery system for target oriented drug delivery with minimum side effects of tamoxifen during cancer treatment.

Se@SiO2–FA–CuS nanocomposites for targeted delivery of DOX and nano selenium in synergistic combination of chemo-photothermal therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 2866-2875 ◽  
Author(s):  
Yeying Wang ◽  
Xijian Liu ◽  
Guoying Deng ◽  
Jian Sun ◽  
Haikuan Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Stimuli Responsive ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Synergistic Combination

A tumor-targeted and multi-stimuli-responsive drug delivery vehicle (Se@SiO2–FA–CuS/DOX) was fabricated for combined PTT with chemotherapy of DOX and Se in cancer treatment.

Multifunctional nanocarriers based on graphitic-C3N4 quantum dots for tumor-targeted, traceable and pH-responsive drug delivery

2019 ◽  
Vol 43 (43) ◽  
pp. 17078-17089 ◽  
Author(s):  
Wenxian Zhang ◽  
Jian Dong ◽  
Guangyao Dang ◽  
Haiwei Ji ◽  
Peng Jiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Cellular Level ◽  
Ph Responsive ◽  
Multifunctional Nanocarriers

A multifunctional nanocarrier is developed for simultaneous targeted delivery, efficient tracking and cancer treatment at the cellular level.

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