Multifunctional nanocarriers based on graphitic-C3N4 quantum dots for tumor-targeted, traceable and pH-responsive drug delivery

2019 ◽  
Vol 43 (43) ◽  
pp. 17078-17089 ◽  
Author(s):  
Wenxian Zhang ◽  
Jian Dong ◽  
Guangyao Dang ◽  
Haiwei Ji ◽  
Peng Jiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Cellular Level ◽  
Ph Responsive ◽  
Multifunctional Nanocarriers

A multifunctional nanocarrier is developed for simultaneous targeted delivery, efficient tracking and cancer treatment at the cellular level.

scholarly journals Amino acid-modified PAMAM dendritic nanocarriers as effective chemotherapeutic drug vehicles in cancer treatment: a study using zebrafish as a cancer model

RSC Advances ◽  
2020 ◽  
Vol 10 (35) ◽  
pp. 20682-20690 ◽  
Author(s):  
Szu-Yuan Wu ◽  
Hsiao-Ying Chou ◽  
Hsieh-Chih Tsai ◽  
Rajeshkumar Anbazhagan ◽  
Chiou-Hwa Yuh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Amino Acid ◽  
Controlled Release ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Chemotherapeutic Drug ◽  
Cancer Model

The use of nanomaterials for drug delivery offers many advantages including the controlled release and their targeted delivery.

scholarly journals Targeted Delivery of Narrow-Spectrum Protein Antibiotics to the Lower Gastrointestinal Tract in a Murine Model of Escherichia coli Colonization

2021 ◽  
Vol 12 ◽  
Author(s):  
Nuria Carpena ◽  
Kerry Richards ◽  
Teresita D. J. Bello Gonzalez ◽  
Alberto Bravo-Blas ◽  
Nicholas G. Housden ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Drug Delivery ◽  
Controlled Release ◽  
Animal Models ◽  
Targeted Delivery ◽  
Intestinal Colonization ◽  
Ph Responsive ◽  
Human Gut ◽  
E Coli

Bacteriocins are narrow-spectrum protein antibiotics that could potentially be used to engineer the human gut microbiota. However, technologies for targeted delivery of proteins to the lower gastrointestinal (GI) tract in preclinical animal models are currently lacking. In this work, we have developed methods for the microencapsulation of Escherichia coli targeting bacteriocins, colicin E9 and Ia, in a pH responsive formulation to allow their targeted delivery and controlled release in an in vivo murine model of E. coli colonization. Membrane emulsification was used to produce a water-in-oil emulsion with the water-soluble polymer subsequently cross-linked to produce hydrogel microcapsules. The microcapsule fabrication process allowed control of the size of the drug delivery system and a near 100% yield of the encapsulated therapeutic cargo. pH-triggered release of the encapsulated colicins was achieved using a widely available pH-responsive anionic copolymer in combination with alginate biopolymers. In vivo experiments using a murine E. coli intestinal colonization model demonstrated that oral delivery of the encapsulated colicins resulted in a significant decrease in intestinal colonization and reduction in E. coli shedding in the feces of the animals. Employing controlled release drug delivery systems such as that described here is essential to enable delivery of new protein therapeutics or other biological interventions for testing within small animal models of infection. Such approaches may have considerable value for the future development of strategies to engineer the human gut microbiota, which is central to health and disease.

Formulation and clinical perspectives of inhalation-based nanocarrier delivery: a new archetype in lung cancer treatment

2021 ◽  
Vol 12 (5) ◽  
pp. 397-418
Author(s):  
Denish Bardoliwala ◽  
Ankit Javia ◽  
Saikat Ghosh ◽  
Ambikanandan Misra ◽  
Krutika Sawant
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Cancer Therapeutics ◽  
High Dose ◽  
Lung Cancer Treatment ◽  
Inhalation Delivery ◽  
Lung Cancer Therapy ◽  
Core Part

Despite tremendous research in targeted delivery and specific molecular inhibitors (gene delivery), cytotoxic drug delivery through inhalation has been seen as a core part in the treatment of the lung cancer. Inhalation delivery provides a high dose of the drug directly to the lungs without affecting other body organs, increasing the therapeutic ratio. This article reviews the research performed over the last several decades regarding inhalation delivery of various cancer therapeutics for the treatment of lung cancer. Nevertheless, pulmonary administration of nanocarrier-based cancer therapeutics for lung cancer therapy is still in its infancy and faces greater than expected challenges. This article focuses on the current inhalable nanocarrier-based drugs for lung cancer treatment.

PEGylated MoS2 quantum dots for traceable and pH-responsive chemotherapeutic drug delivery

2020 ◽  
Vol 185 ◽  
pp. 110590 ◽  
Author(s):  
Li Liu ◽  
Hongli Jiang ◽  
Jian Dong ◽  
Wenxian Zhang ◽  
Guangyao Dang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Chemotherapeutic Drug ◽  
Ph Responsive

A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways

Nanoscale ◽  
2017 ◽  
Vol 9 (27) ◽  
pp. 9428-9439 ◽  
Author(s):  
Kai Jiang ◽  
Ting Chi ◽  
Tao Li ◽  
Guirong Zheng ◽  
Lulu Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Ursolic Acid ◽  
Delivery System ◽  
Targeted Delivery ◽  
Cancer Growth ◽  
Ph Responsive ◽  
Nanodrug Delivery ◽  
System P ◽  
Multiple Signaling

Anti-tumor and anti-metastatic effects of ursolic acid based on one novel nanodrug delivery system.

scholarly journals Peptide- and saccharide-conjugated dendrimers for targeted drug delivery: a concise review

2012 ◽  
Vol 2 (3) ◽  
pp. 307-324 ◽  
Author(s):  
Jie Liu ◽  
Warren D. Gray ◽  
Michael E. Davis ◽  
Ying Luo
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Drug Efficacy ◽  
Cellular Level ◽  
Synthesis Methods ◽  
Chemical Structures ◽  
Bioactive Ligands ◽  
Conjugated Dendrimers ◽  
Function Relationship ◽  
Dendrimer Conjugates

Dendrimers comprise a category of branched materials with diverse functions that can be constructed with defined architectural and chemical structures. When decorated with bioactive ligands made of peptides and saccharides through peripheral chemical groups, dendrimer conjugates are turned into nanomaterials possessing attractive binding properties with the cognate receptors. At the cellular level, bioactive dendrimer conjugates can interact with cells with avidity and selectivity, and this function has particularly stimulated interests in investigating the targeting potential of dendrimer materials for the design of drug delivery systems. In addition, bioactive dendrimer conjugates have so far been studied for their versatile capabilities to enhance stability, solubility and absorption of various types of therapeutics. This review presents a brief discussion on three aspects of the recent studies to use peptide- and saccharide-conjugated dendrimers for drug delivery: (i) synthesis methods, (ii) cell- and tissue-targeting properties and (iii) applications of conjugated dendrimers in drug delivery nanodevices. With more studies to elucidate the structure–function relationship of ligand–dendrimer conjugates in transporting drugs, the conjugated dendrimers hold promise to facilitate targeted delivery and improve drug efficacy for discovery and development of modern pharmaceutics.

scholarly journals Correction: A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways

Nanoscale ◽  
2018 ◽  
Vol 10 (13) ◽  
pp. 6212-6213 ◽  
Author(s):  
Kai Jiang ◽  
Ting Chi ◽  
Tao Li ◽  
Guirong Zheng ◽  
Lulu Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Signaling Pathways ◽  
Drug Delivery System ◽  
Ursolic Acid ◽  
Delivery System ◽  
Targeted Delivery ◽  
Cancer Growth ◽  
Ph Responsive ◽  
Multiple Signaling

Correction for ‘A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways’ by Kai Jiang et al., Nanoscale, 2017, 9, 9428–9439.

IRON OXIDE MAGNETIC NANOPARTICLES AS DRUG DELIVERY SYSTEMS FOR BRAIN CANCER TREATMENT

2021 ◽  
Vol 2 (1) ◽  
pp. 55-66
Author(s):  
Oana Stefana Purcaru ◽  
Alexandra Costachi ◽  
Catalina Elena Cioc ◽  
Alice Buteica ◽  
Anica Dricu
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
High Grade Glioma ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Vitro Effect

Nanotechnology offers a new horizon for cancer drug administration and systemic safety of oncological treatments. Compared with conventional pharmaceutical forms, nanoparticles (NPs) have many advantages such as larger surface, ability to adsorb and targeted delivery of different types of drugs, providing decreased side effects and a patient customed approach in cancer treatment. Due to their diverse chemical composition, NPs offer the possibility of developing innovative therapies, which may be also applied in glioblastoma treatment. Fe3O4 magnetic nanoparticles (MNPs) have been previously used in cancer treatment, as targeted drug delivery systems. Helianthin is an azo dye compound that we found to induce cell death in high grade glioma (HGG) cells. In this study, we analyzed the in vitro effect of MNPs loaded with Helianthin (HeMNPs) on a glioblastoma cell line (GB2B).

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