scholarly journals Polydopamine Modified Superparamagnetic Iron Oxide Nanoparticles as Multifunctional Nanocarrier for Targeted Prostate Cancer Treatment

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 138 ◽  
Author(s):  
Nimisha Singh ◽  
Fadoua Sallem ◽  
Celine Mirjolet ◽  
Thomas Nury ◽  
Suban Kumar Sahoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photoelectron Spectroscopy ◽  
Targeted Delivery ◽  
Easy Access ◽  
Shell Nanoparticles ◽  
Vis Spectroscopy

Polydopamine (pDA)-modified iron oxide core-shell nanoparticles (IONPs) are developed and designed as nanovectors of drugs. Reactive quinone of pDA enhances the binding efficiency of various biomolecules for targeted delivery. Glutathione disulfide (GSSG), an abundant thiol species in the cytoplasm, was immobilized on the pDA-IONP surface. It serves as a cellular trigger to release the drug from the nanoparticles providing an efficient platform for the drug delivery system. Additionally, GSSG on the surface was further modified to form S-nitrosoglutathione that can act as nitric oxide (NO) donors. These NPs were fully characterized using a transmission electronic microscopy (TEM), thermogravimetric analysis (TGA), dynamic light scattering (DLS), zeta potential, X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) and UV-vis spectroscopies. Doxorubicin (DOX) and docetaxel (DTX) are two anticancer drugs, which were loaded onto nanoparticles with respective loading efficiencies of 243 and 223 µmol/g of IONPs, calculated using TGA measurements. DOX release study, using UV-vis spectroscopy, showed a pH responsive behavior, making the elaborated nanocarrier a potential drug delivery system. (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl) -2H-tetrazolium (MTS) and apoptosis assays were performed on PC3 cell lines to evaluate the efficiency of the developed nanocarriers. These nanoparticles thus can prove their worth in cancer treatment on account of their easy access to the site and release of drug in response to changes to internal parameters such as pH, chemicals, etc.

scholarly journals A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Weiwei Mu ◽  
Qihui Chu ◽  
Yongjun Liu ◽  
Na Zhang
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Cancer Patients ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Chemotherapeutic Agents ◽  
Therapeutic Effects ◽  
Cancer Treatments ◽  
Powerful Strategy

AbstractAlthough notable progress has been made on novel cancer treatments, the overall survival rate and therapeutic effects are still unsatisfactory for cancer patients. Chemoimmunotherapy, combining chemotherapeutics and immunotherapeutic drugs, has emerged as a promising approach for cancer treatment, with the advantages of cooperating two kinds of treatment mechanism, reducing the dosage of the drug and enhancing therapeutic effect. Moreover, nano-based drug delivery system (NDDS) was applied to encapsulate chemotherapeutic agents and exhibited outstanding properties such as targeted delivery, tumor microenvironment response and site-specific release. Several nanocarriers have been approved in clinical cancer chemotherapy and showed significant improvement in therapeutic efficiency compared with traditional formulations, such as liposomes (Doxil®, Lipusu®), nanoparticles (Abraxane®) and micelles (Genexol-PM®). The applications of NDDS to chemoimmunotherapy would be a powerful strategy for future cancer treatment, which could greatly enhance the therapeutic efficacy, reduce the side effects and optimize the clinical outcomes of cancer patients. Herein, the current approaches of cancer immunotherapy and chemoimmunotherapy were discussed, and recent advances of NDDS applied for chemoimmunotherapy were further reviewed.

Bioevaluation of glucose-modified liposomes as a potential drug delivery system for cancer treatment using 177-Lu radiotracking

2021 ◽  
Vol 332 ◽  
pp. 301-311
Author(s):  
Đorđe Cvjetinović ◽  
Željko Prijović ◽  
Drina Janković ◽  
Magdalena Radović ◽  
Marija Mirković ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Drug

Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment

2018 ◽  
Vol 17 (10) ◽  
pp. 668-688 ◽  
Author(s):  
N.M. Salkho ◽  
R.Z. Turki ◽  
O. Guessoum ◽  
A.M. Martins ◽  
R.F. Vitor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System

Magnetic Janus particles as a multifunctional drug delivery system for paclitaxel in efficient cancer treatment

2019 ◽  
Vol 104 ◽  
pp. 110001 ◽  
Author(s):  
Zhang-Qi Feng ◽  
Ke Yan ◽  
Jiacheng Li ◽  
Xuran Xu ◽  
Tao Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Janus Particles

scholarly journals Novel Surface Modification of ZnO QDs for Paclitaxel-Targeted Drug Delivery for Lung Cancer Treatment

Dose-Response ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 155932582092673
Author(s):  
Chuan Xie ◽  
Yan Zhan ◽  
Peng Wang ◽  
Bo Zhang ◽  
Yukun Zhang
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
High Efficiency ◽  
A549 Cells ◽  
Cytotoxicity Studies

Adipic dihydrazide and heparin were attached to ZnO quantum dots surface, and the ZnO-adipic dihydrazide-heparin nanocomplex was used as a drug delivery system to deliver paclitaxel for chemotherapy. The surface modification and the loading of paclitaxel were confirmed by Fourier transform infrared spectrum, featured by characteristic peaks from functional groups of adipic dihydrazide, heparin, and paclitaxel. The impacts of pH on the drug release were investigated, and the cytotoxicity studies were conducted with A549 cells. The pharmacokinetic study was conducted with male Wistar rats. Both in vitro and in vivo study indicated that ZnO-adipic dihydrazide-heparin-paclitaxel nanocomplex could deliver paclitaxel in a more controllable way, and it has the potential to be a high-efficiency drug delivery system for cancer treatment.

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