Flow synthesis approaches to privileged scaffolds – recent routes reviewed for green and sustainable aspects

2021 ◽  
Vol 23 (6) ◽  
pp. 2233-2292
Author(s):  
Antonella Ilenia Alfano ◽  
Margherita Brindisi ◽  
Heiko Lange
Keyword(s):  
Green Chemistry ◽  
Flow Chemistry ◽  
Diversity Oriented Synthesis ◽  
Flow Synthesis ◽  
Versatile Tool ◽  
Privileged Scaffolds

This review discusses the use of flow chemistry as versatile tool for the synthesis and derivatisation of privileged scaffolds, looking at applicability, diversity-oriented synthesis options, inherent sustainability and green chemistry aspects.

6 From green chemistry principles to sustainable flow chemistry

2021 ◽  
pp. 159-192
Author(s):  
Francesco Ferlin ◽  
Nam Nghiep Tran ◽  
Aikaterini Anastasopoulou ◽  
Marc Escribà Gelonch ◽  
Daniela Lanari ◽  
...  
Keyword(s):  
Green Chemistry ◽  
Flow Chemistry

scholarly journals Continuous flow synthesis of phase transition-resistant titania microparticles with tunable morphologies

RSC Advances ◽  
2020 ◽  
Vol 10 (14) ◽  
pp. 8340-8347 ◽  
Author(s):  
Zachary S. Campbell ◽  
Daniel Jackson ◽  
Jacob Lustik ◽  
Amur K. Al-Rashdi ◽  
Jeffrey A. Bennett ◽  
...  
Keyword(s):  
Phase Transition ◽  
Continuous Flow ◽  
High Surface ◽  
Flow Chemistry ◽  
Flow Focusing ◽  
Flow Synthesis ◽  
Surface Areas ◽  
Uv Led ◽  
Anatase Titania

A flow chemistry strategy for synthesis of anatase titania microparticles utilizing a flow-focusing microreactor integrated with a collimated UV LED is presented. The synthesized microparticles possess a wide variety of morphologies and high surface areas (up to 362 m2 g−1).

A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

RSC Advances ◽  
2015 ◽  
Vol 5 (2) ◽  
pp. 1268-1273 ◽  
Author(s):  
Monica Viviano ◽  
Ciro Milite ◽  
Donatella Rescigno ◽  
Sabrina Castellano ◽  
Gianluca Sbardella
Keyword(s):  
Drug Discovery ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Privileged Structure ◽  
Privileged Scaffolds

A continuous-flow strategy to achieve the benzodiazepine privileged structure.

Synthesis of Privileged Scaffolds by Using Diversity-Oriented Synthesis

2013 ◽  
Vol 8 (6) ◽  
pp. 1168-1176 ◽  
Author(s):  
Ramu Surakanti ◽  
Sumalatha Sanivarapu ◽  
Chiranjeevi Thulluri ◽  
Pravin S. Iyer ◽  
Raghuram S. Tangirala ◽  
...  
Keyword(s):  
Diversity Oriented Synthesis ◽  
Privileged Scaffolds

scholarly journals Continuous enzymatic stirred tank reactor cascade with unconventional medium yielding high concentrations of (S)-2-hydroxyphenyl propanone and its derivatives

2021 ◽  
Author(s):  
Reinhard Oeggl ◽  
Juliane Diedrich ◽  
Eric von Lieres ◽  
Dörte Rother
Keyword(s):  
Green Chemistry ◽  
Flow Chemistry ◽  
Stirred Tank ◽  
Stirred Tank Reactor ◽  
Tank Reactor ◽  
High Substrate ◽  
High Concentrations ◽  
Substrate Concentrations

The implementation of biocatalysis in flow chemistry offers synergistic synthesis advantages in line with green chemistry principles. Yet, the conversion of high substrate concentrations is most often hindered by substrate...

Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds

2020 ◽  
Vol 5 (11) ◽  
pp. 2091-2100
Author(s):  
Antonella Ilenia Alfano ◽  
Angela Zampella ◽  
Ettore Novellino ◽  
Margherita Brindisi ◽  
Heiko Lange
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Privileged Scaffolds

3,3-Disubstituted indolenines are obtained via a green and sustainable flow chemistry protocol for interrupted Fischer indolisation reactions.

scholarly journals Combining Radial and Continuous Flow Synthesis to Optimize and Scale-up the Production of Medicines

2021 ◽  
Author(s):  
Mara Guidi ◽  
Soo-Yeon Moon ◽  
Lucia Anghileri ◽  
Dario Cambié ◽  
Peter Seeberger ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Scale Up ◽  
Flow Chemistry ◽  
Essential Medicines ◽  
Flow Synthesis ◽  
Drug Production ◽  
On Demand ◽  
Current Drug

Current drug production in batch cannot adapt rapidly to market demands, evidenced by recent shortages in many markets globally of essential medicines. Flow chemistry is a valuable tool for on-demand...

scholarly journals Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3242 ◽  
Author(s):  
Marco Colella ◽  
Leonardo Degennaro ◽  
Renzo Luisi
Keyword(s):  
Drug Discovery ◽  
Continuous Flow ◽  
Medicinal Chemistry ◽  
Flow Chemistry ◽  
Modern Synthesis ◽  
Indole Derivatives ◽  
Flow Synthesis

Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis. In this review, the role of flow technology in the preparation of indole derivatives is showcased. Selected examples have been described with the aim to provide readers with an overview on the tactics and technologies used for targeting indole scaffolds.

Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library

MedChemComm ◽  
2016 ◽  
Vol 7 (3) ◽  
pp. 439-446 ◽  
Author(s):  
Bruno Cerra ◽  
Serena Mostarda ◽  
Chiara Custodi ◽  
Antonio Macchiarulo ◽  
Antimo Gioiello
Keyword(s):  
Flow Chemistry ◽  
Multicomponent Flow ◽  
Computational Tools ◽  
Computational Approaches ◽  
Flow Synthesis

The combination of flow chemistry and computational tools has been successfully applied to prepare a focused library of tricyclic tetrahydroquinolines endowed with drug-like properties.

Continuous Flow Synthesis of Coumarin

2013 ◽  
Vol 781-784 ◽  
pp. 936-941 ◽  
Author(s):  
An Bang Chen ◽  
Xin Li ◽  
Yang Zhi Zhou ◽  
Ling Ling Huang ◽  
Zheng Fang ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Emerging Technology ◽  
High Conversion ◽  
Small Scale ◽  
Flow Synthesis

Flow chemistry, as a rapidly emerging technology, is exploited to provide a safe and scalable route for the pharmaceutically interesting coumarin. Here, a continuous flow approach for the generation of coumarin is reported, which relies on the two connected coil reactors design. The synthesis of coumarin has been performed successfully in high conversion on small scale and can be scaled up substantially.

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