A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

RSC Advances ◽  
2015 ◽  
Vol 5 (2) ◽  
pp. 1268-1273 ◽  
Author(s):  
Monica Viviano ◽  
Ciro Milite ◽  
Donatella Rescigno ◽  
Sabrina Castellano ◽  
Gianluca Sbardella
Keyword(s):  
Drug Discovery ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Privileged Structure ◽  
Privileged Scaffolds

A continuous-flow strategy to achieve the benzodiazepine privileged structure.

ChemInform Abstract: A Continuous-Flow Synthesis of 1,4-Benzodiazepin-5-ones, Privileged Scaffolds for Drug Discovery.

ChemInform ◽  
2015 ◽  
Vol 46 (20) ◽  
pp. no-no
Author(s):  
Monica Viviano ◽  
Ciro Milite ◽  
Donatella Rescigno ◽  
Sabrina Castellano ◽  
Gianluca Sbardella
Keyword(s):  
Drug Discovery ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Privileged Scaffolds

scholarly journals Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3242 ◽  
Author(s):  
Marco Colella ◽  
Leonardo Degennaro ◽  
Renzo Luisi
Keyword(s):  
Drug Discovery ◽  
Continuous Flow ◽  
Medicinal Chemistry ◽  
Flow Chemistry ◽  
Modern Synthesis ◽  
Indole Derivatives ◽  
Flow Synthesis

Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis. In this review, the role of flow technology in the preparation of indole derivatives is showcased. Selected examples have been described with the aim to provide readers with an overview on the tactics and technologies used for targeting indole scaffolds.

Continuous flow synthesis of the lamivudine precursor L-Menthyl Glyoxylate

2021 ◽  
Author(s):  
Lais S. D. Azevedo ◽  
Anderson R. Aguillon ◽  
Marcelo T. Lima ◽  
Raquel A. C. Leão ◽  
Rodrigo O. M. A. de Souza
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis

Continuous Flow Synthesis of Persistent Luminescent Chromium-Doped Zinc Gallate Nanoparticles

2021 ◽  
pp. 7067-7075
Author(s):  
Xiaojun Wei ◽  
Stephen V. Kershaw ◽  
Xiaodan Huang ◽  
Mingxia Jiao ◽  
Chau Chun Beh ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Zinc Gallate

scholarly journals Continuous flow synthesis of azoxybenzenes by reductive dimerization of nitrosobenzenes with gel‐bound catalysts

2021 ◽  
Author(s):  
Carsten J. Schmiegel ◽  
Patrik Berg ◽  
Franziska Obst ◽  
Roland Schoch ◽  
Dietmar Appelhans ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Reductive Dimerization

scholarly journals Continuous Flow Synthesis of Metal–NHC Complexes**

2021 ◽  
Vol 27 (18) ◽  
pp. 5653-5657 ◽  
Author(s):  
Andreas Simoens ◽  
Thomas Scattolin ◽  
Thibault Cauwenbergh ◽  
Gianmarco Pisanò ◽  
Catherine S. J. Cazin ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis

scholarly journals Continuous‐Flow Synthesis of High‐Quality Few‐Layer Antimonene Hexagons

2021 ◽  
pp. 2101616
Author(s):  
Iñigo Torres ◽  
Marta Alcaraz ◽  
Roger Sanchis‐Gual ◽  
Jose A. Carrasco ◽  
Michael Fickert ◽  
...  
Keyword(s):  
Continuous Flow ◽  
High Quality ◽  
Flow Synthesis

scholarly journals Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 303
Author(s):  
András Gy. Németh ◽  
Renáta Szabó ◽  
György Orsy ◽  
István M. Mándity ◽  
György M. Keserű ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Mild Conditions ◽  
Wide Range ◽  
Simple Filtration

We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.

scholarly journals Continuous‐Flow Synthesis of ZIF‐8 Biocomposites with Tunable Particle Size

2020 ◽  
Vol 59 (21) ◽  
pp. 8123-8127 ◽  
Author(s):  
Francesco Carraro ◽  
Jason D. Williams ◽  
Mercedes Linares‐Moreau ◽  
Chiara Parise ◽  
Weibin Liang ◽  
...  
Keyword(s):  
Particle Size ◽  
Continuous Flow ◽  
Flow Synthesis

scholarly journals Nanofiltration-Enabled In Situ Solvent and Reagent Recycle for Sustainable Continuous-Flow Synthesis

ChemSusChem ◽  
2017 ◽  
Vol 10 (17) ◽  
pp. 3435-3444 ◽  
Author(s):  
Tamas Fodi ◽  
Christos Didaskalou ◽  
Jozsef Kupai ◽  
Gyorgy T. Balogh ◽  
Peter Huszthy ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis
Sign in / Sign up

Export Citation Format

Share Document