scholarly journals Continuous flow synthesis of phase transition-resistant titania microparticles with tunable morphologies

RSC Advances ◽  
2020 ◽  
Vol 10 (14) ◽  
pp. 8340-8347 ◽  
Author(s):  
Zachary S. Campbell ◽  
Daniel Jackson ◽  
Jacob Lustik ◽  
Amur K. Al-Rashdi ◽  
Jeffrey A. Bennett ◽  
...  
Keyword(s):  
Phase Transition ◽  
Continuous Flow ◽  
High Surface ◽  
Flow Chemistry ◽  
Flow Focusing ◽  
Flow Synthesis ◽  
Surface Areas ◽  
Uv Led ◽  
Anatase Titania

A flow chemistry strategy for synthesis of anatase titania microparticles utilizing a flow-focusing microreactor integrated with a collimated UV LED is presented. The synthesized microparticles possess a wide variety of morphologies and high surface areas (up to 362 m2 g−1).

High-throughput continuous hydrothermal flow synthesis of Zn–Ce oxides: unprecedented solubility of Zn in the nanoparticle fluorite lattice

2010 ◽  
Vol 368 (1927) ◽  
pp. 4331-4349 ◽  
Author(s):  
Suela Kellici ◽  
Kenan Gong ◽  
Tian Lin ◽  
Sonal Brown ◽  
Robin J. H. Clark ◽  
...  
Keyword(s):  
High Resolution ◽  
High Throughput ◽  
High Surface ◽  
Fluorite Structure ◽  
Synthetic Methods ◽  
Flow Synthesis ◽  
X Ray ◽  
Surface Areas ◽  
Phase Pure ◽  
Hydrothermal Flow

High-throughput continuous hydrothermal flow synthesis has been used as a rapid and efficient synthetic route to produce a range of crystalline nanopowders in the Ce–Zn oxide binary system. High-resolution powder X-ray diffraction data were obtained for both as-prepared and heat-treated (850°C for 10 h in air) samples using the new robotic beamline I11, located at Diamond Light Source. The influence of the sample composition on the crystal structure and on the optical and physical properties was studied. All the nanomaterials were characterized using Raman spectroscopy, UV–visible spectrophotometry, Brunauer–Emmett–Teller surface area and elemental analysis (via energy-dispersive X-ray spectroscopy). Initially, for ‘as-prepared’ Ce 1− x Zn x O y , a phase-pure cerium oxide (fluorite) structure was obtained for nominal values of x =0.1 and 0.2. Biphasic mixtures were obtained for nominal values of x in the range of 0.3–0.9 (inclusive). High-resolution transmission electron microscopy images revealed that the phase-pure nano-CeO 2 ( x =0) consisted of ca 3.7 nm well-defined nanoparticles. The nanomaterials produced herein generally had high surface areas (greater than 150 m 2  g −1 ) and possessed combinations of particle properties (e.g. bandgap, crystallinity, size, etc.) that were unobtainable or difficult to achieve by other more conventional synthetic methods.

scholarly journals Combining Radial and Continuous Flow Synthesis to Optimize and Scale-up the Production of Medicines

2021 ◽  
Author(s):  
Mara Guidi ◽  
Soo-Yeon Moon ◽  
Lucia Anghileri ◽  
Dario Cambié ◽  
Peter Seeberger ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Scale Up ◽  
Flow Chemistry ◽  
Essential Medicines ◽  
Flow Synthesis ◽  
Drug Production ◽  
On Demand ◽  
Current Drug

Current drug production in batch cannot adapt rapidly to market demands, evidenced by recent shortages in many markets globally of essential medicines. Flow chemistry is a valuable tool for on-demand...

scholarly journals Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3242 ◽  
Author(s):  
Marco Colella ◽  
Leonardo Degennaro ◽  
Renzo Luisi
Keyword(s):  
Drug Discovery ◽  
Continuous Flow ◽  
Medicinal Chemistry ◽  
Flow Chemistry ◽  
Modern Synthesis ◽  
Indole Derivatives ◽  
Flow Synthesis

Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis. In this review, the role of flow technology in the preparation of indole derivatives is showcased. Selected examples have been described with the aim to provide readers with an overview on the tactics and technologies used for targeting indole scaffolds.

Continuous Flow Synthesis of Coumarin

2013 ◽  
Vol 781-784 ◽  
pp. 936-941 ◽  
Author(s):  
An Bang Chen ◽  
Xin Li ◽  
Yang Zhi Zhou ◽  
Ling Ling Huang ◽  
Zheng Fang ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Emerging Technology ◽  
High Conversion ◽  
Small Scale ◽  
Flow Synthesis

Flow chemistry, as a rapidly emerging technology, is exploited to provide a safe and scalable route for the pharmaceutically interesting coumarin. Here, a continuous flow approach for the generation of coumarin is reported, which relies on the two connected coil reactors design. The synthesis of coumarin has been performed successfully in high conversion on small scale and can be scaled up substantially.

scholarly journals One-flow synthesis of tetrahydrocannabinol and cannabidiol using homo- and heterogeneous Lewis acids

2021 ◽  
Author(s):  
Victor R. L. J. Bloemendal ◽  
Bram Spierenburg ◽  
Thomas J. Boltje ◽  
Jan C. M. van Hest ◽  
Floris P. J. T. Rutjes
Keyword(s):  
Continuous Flow ◽  
Lewis Acids ◽  
Ring Opening ◽  
Flow System ◽  
Flow Chemistry ◽  
Batch Processes ◽  
Flow Synthesis ◽  
Biologically Relevant ◽  
Continuous Flow Chemistry ◽  
Biologically Relevant Molecules

AbstractContinuous flow chemistry holds great potential for the production of biologically relevant molecules. Herein, we present an approach for the continuous synthesis of cannabidiol and tetrahydrocannabinol in a one-flow system. The designed route consists of a reaction cascade involving Friedel-Crafts alkylation, subsequent ring opening and cyclisation in up to 45% yield. The reactions were successfully performed using both hetero- and homogeneous Lewis acids in continuous flow and provide yields that are similar to comparable batch processes. Graphical abstract

Highly effective synthesis of a cobalt(ii) metal–organic coordination polymer by using continuous flow chemistry

2017 ◽  
Vol 46 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Chunhua Gong ◽  
Junyong Zhang ◽  
Xianghua Zeng ◽  
Jingli Xie
Keyword(s):  
Coordination Polymer ◽  
Continuous Flow ◽  
Flow Chemistry ◽  
Synthesis System ◽  
Flow Synthesis ◽  
Flow Type ◽  
Continuous Flow Chemistry ◽  
Highly Effective ◽  
Metal Organic ◽  
Effective Synthesis

By using an Asia flow synthesis system (chip reactor), a new coordination polymer [Co2L4(H2O)2]·CH3CN·H2O (HL = (E)-2-[2-(4-chlorophenyl)vinyl]-8-hydroxyquinoline) has been achieved with 95% yield, demonstrating the uniqueness of flow-type reactions.

From alcohol to 1,2,3-triazole via a multi-step continuous-flow synthesis of a rufinamide precursor

2016 ◽  
Vol 18 (18) ◽  
pp. 4947-4953 ◽  
Author(s):  
Svetlana Borukhova ◽  
Timothy Noël ◽  
Bert Metten ◽  
Eric de Vos ◽  
Volker Hessel
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Continuous Manufacturing ◽  
Flow Synthesis

Bringing the strongest suits of flow chemistry together to deliver the greenest possible process for continuous manufacturing of a rufinamide precursor.

Room Temperature Flow Electrochemistry as a Means of Retaining the “Memory of Chirality” via Hofer Moest Type Reaction

2020 ◽  
Author(s):  
Tomas Hardwick ◽  
Rossana Cicala ◽  
Nisar Ahmed
Keyword(s):  
Continuous Flow ◽  
Room Temperature ◽  
Biological Activities ◽  
Supporting Electrolyte ◽  
Enantiomeric Excess ◽  
Flow Chemistry ◽  
Batch Processes ◽  
Enabling Technology ◽  
Chiral Compounds ◽  
Memory Of Chirality

<p>Many chiral compounds have become of great interest to the pharmaceutical industry as they possess various biological activities. Concurrently, the concept of “memory of chirality” has been proven as a powerful tool in asymmetric synthesis, while flow chemistry has begun its rise as a new enabling technology to add to the ever increasing arsenal of techniques available to the modern day chemist. Here, we have employed a new simple electrochemical microreactor design to oxidise an L-proline derivative at room temperature in continuous flow. Flow performed in microreactors offers up a number of benefits allowing reactions to be performed in a more convenient and safer manner, and even allow electrochemical reactions to take place without a supporting electrolyte due to a very short interelectrode distance. By the comparison of electrochemical oxidations in batch and flow we have found that continuous flow is able to outperform its batch counterpart, producing a good yield (71%) and a better enantiomeric excess (64%) than batch with a 98% conversion. We have, therefore, provided evidence that continuous flow chemistry has the potential to act as a new enabling technology to replace some aspects of conventional batch processes. </p>

A Highly Crystalline Anthracene-Based MOF-74 Series Featuring Electrical Conductivity and Luminescence

2019 ◽  
Author(s):  
Patricia Scheurle ◽  
Andre Mähringer ◽  
Andreas Jakowetz ◽  
Pouya Hosseini ◽  
Alexander Richter ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Metal Ions ◽  
Light Emission ◽  
Block Design ◽  
High Surface ◽  
Visible Spectrum ◽  
Building Blocks ◽  
Divalent Metal Ions ◽  
Conductivity Enhancement ◽  
Surface Areas

Recently, a small group of metal-organic frameworks (MOFs) has been discovered featuring substantial charge transport properties and electrical conductivity, hence promising to broaden the scope of potential MOF applications in fields such as batteries, fuel cells and supercapacitors. In combination with light emission, electroactive MOFs are intriguing candidates for chemical sensing and optoelectronic applications. Here, we incorporated anthracene-based building blocks into the MOF-74 topology with five different divalent metal ions, that is, Zn2+, Mg2+, Ni2+, Co2+ and Mn2+, resulting in a series of highly crystalline MOFs, coined ANMOF-74(M). This series of MOFs features substantial photoluminescence, with ANMOF-74(Zn) emitting across the whole visible spectrum. The materials moreover combine this photoluminescence with high surface areas and electrical conductivity. Compared to the original MOF-74 materials constructed from 2,5-dihydroxy terephthalic acid and the same metal ions Zn2+, Mg2+, Ni2+, Co2+ and Mn2+, we observed a conductivity enhancement of up to six orders of magnitude. Our results point towards the importance of building block design and the careful choice of the embedded MOF topology for obtaining materials with desired properties such as photoluminescence and electrical conductivity.

Removal of microcystin-LR from drinking water with TiO2-coated activated carbon

2004 ◽  
Vol 4 (5-6) ◽  
pp. 21-28
Author(s):  
S.-C. Kim ◽  
D.-K. Lee
Keyword(s):  
Drinking Water ◽  
Activated Carbon ◽  
Synergistic Effect ◽  
Fluidized Bed ◽  
Continuous Flow ◽  
High Surface ◽  
High Surface Area ◽  
Fluidized Bed Reactor ◽  
Exterior Surface ◽  
Tio2 Particles

TiO2-coated granular activated carbon was employed for the removal of toxic microcystin-LR from water. High surface area of the activated carbon provided sites for the adsorption of microcystin-LR, and the adsorbed microcystin-LR migrated continuously onto the surface of TiO2 particles which located mainly at the exterior surface in the vicinity of the entrances of the macropores of the activated carbon. The migrated microcystin-LR was finally degraded into nontoxic products and CO2 very quickly. These combined roles of the activated carbon and TiO2 showed a synergistic effect on the efficient degradation of toxic microcystin-LR. A continuous flow fluidized bed reactor with the TiO2-coated activated carbon could successfully be employed for the efficient photocatalytic of microcystin-LR.

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