scholarly journals Combining Radial and Continuous Flow Synthesis to Optimize and Scale-up the Production of Medicines

2021 ◽  
Author(s):  
Mara Guidi ◽  
Soo-Yeon Moon ◽  
Lucia Anghileri ◽  
Dario Cambié ◽  
Peter Seeberger ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Scale Up ◽  
Flow Chemistry ◽  
Essential Medicines ◽  
Flow Synthesis ◽  
Drug Production ◽  
On Demand ◽  
Current Drug

Current drug production in batch cannot adapt rapidly to market demands, evidenced by recent shortages in many markets globally of essential medicines. Flow chemistry is a valuable tool for on-demand...

Scale-up and Optimization of a Continuous Flow Synthesis of an α-Thio-β-chloroacrylamide

2020 ◽  
Vol 24 (10) ◽  
pp. 1978-1987
Author(s):  
Olga C. Dennehy ◽  
Denis Lynch ◽  
Stuart G. Collins ◽  
Anita R. Maguire ◽  
Humphrey A. Moynihan
Keyword(s):  
Continuous Flow ◽  
Scale Up ◽  
Flow Synthesis

scholarly journals Continuous flow synthesis of phase transition-resistant titania microparticles with tunable morphologies

RSC Advances ◽  
2020 ◽  
Vol 10 (14) ◽  
pp. 8340-8347 ◽  
Author(s):  
Zachary S. Campbell ◽  
Daniel Jackson ◽  
Jacob Lustik ◽  
Amur K. Al-Rashdi ◽  
Jeffrey A. Bennett ◽  
...  
Keyword(s):  
Phase Transition ◽  
Continuous Flow ◽  
High Surface ◽  
Flow Chemistry ◽  
Flow Focusing ◽  
Flow Synthesis ◽  
Surface Areas ◽  
Uv Led ◽  
Anatase Titania

A flow chemistry strategy for synthesis of anatase titania microparticles utilizing a flow-focusing microreactor integrated with a collimated UV LED is presented. The synthesized microparticles possess a wide variety of morphologies and high surface areas (up to 362 m2 g−1).

scholarly journals Continuous-Flow Catalysis

Catalysts ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1066
Author(s):  
Sándor B. Ötvös
Keyword(s):  
Chemical Reactions ◽  
Continuous Flow ◽  
Scale Up ◽  
Flow Chemistry ◽  
The Past

During the past twenty years, flow chemistry has emerged as an enabling tool to simplify, accelerate, integrate, scale-up and automatize chemical reactions [...]

scholarly journals Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3242 ◽  
Author(s):  
Marco Colella ◽  
Leonardo Degennaro ◽  
Renzo Luisi
Keyword(s):  
Drug Discovery ◽  
Continuous Flow ◽  
Medicinal Chemistry ◽  
Flow Chemistry ◽  
Modern Synthesis ◽  
Indole Derivatives ◽  
Flow Synthesis

Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis. In this review, the role of flow technology in the preparation of indole derivatives is showcased. Selected examples have been described with the aim to provide readers with an overview on the tactics and technologies used for targeting indole scaffolds.

Continuous Flow Synthesis of Coumarin

2013 ◽  
Vol 781-784 ◽  
pp. 936-941 ◽  
Author(s):  
An Bang Chen ◽  
Xin Li ◽  
Yang Zhi Zhou ◽  
Ling Ling Huang ◽  
Zheng Fang ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Emerging Technology ◽  
High Conversion ◽  
Small Scale ◽  
Flow Synthesis

Flow chemistry, as a rapidly emerging technology, is exploited to provide a safe and scalable route for the pharmaceutically interesting coumarin. Here, a continuous flow approach for the generation of coumarin is reported, which relies on the two connected coil reactors design. The synthesis of coumarin has been performed successfully in high conversion on small scale and can be scaled up substantially.

Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts

2012 ◽  
Vol 10 (20) ◽  
pp. 4109 ◽  
Author(s):  
Francesco Venturoni ◽  
Antimo Gioiello ◽  
Roccaldo Sardella ◽  
Benedetto Natalini ◽  
Roberto Pellicciari
Keyword(s):  
Continuous Flow ◽  
Bile Salts ◽  
Scale Up ◽  
Flow Synthesis ◽  
Conjugated Bile Salts

scholarly journals One-flow synthesis of tetrahydrocannabinol and cannabidiol using homo- and heterogeneous Lewis acids

2021 ◽  
Author(s):  
Victor R. L. J. Bloemendal ◽  
Bram Spierenburg ◽  
Thomas J. Boltje ◽  
Jan C. M. van Hest ◽  
Floris P. J. T. Rutjes
Keyword(s):  
Continuous Flow ◽  
Lewis Acids ◽  
Ring Opening ◽  
Flow System ◽  
Flow Chemistry ◽  
Batch Processes ◽  
Flow Synthesis ◽  
Biologically Relevant ◽  
Continuous Flow Chemistry ◽  
Biologically Relevant Molecules

AbstractContinuous flow chemistry holds great potential for the production of biologically relevant molecules. Herein, we present an approach for the continuous synthesis of cannabidiol and tetrahydrocannabinol in a one-flow system. The designed route consists of a reaction cascade involving Friedel-Crafts alkylation, subsequent ring opening and cyclisation in up to 45% yield. The reactions were successfully performed using both hetero- and homogeneous Lewis acids in continuous flow and provide yields that are similar to comparable batch processes. Graphical abstract

Highly effective synthesis of a cobalt(ii) metal–organic coordination polymer by using continuous flow chemistry

2017 ◽  
Vol 46 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Chunhua Gong ◽  
Junyong Zhang ◽  
Xianghua Zeng ◽  
Jingli Xie
Keyword(s):  
Coordination Polymer ◽  
Continuous Flow ◽  
Flow Chemistry ◽  
Synthesis System ◽  
Flow Synthesis ◽  
Flow Type ◽  
Continuous Flow Chemistry ◽  
Highly Effective ◽  
Metal Organic ◽  
Effective Synthesis

By using an Asia flow synthesis system (chip reactor), a new coordination polymer [Co2L4(H2O)2]·CH3CN·H2O (HL = (E)-2-[2-(4-chlorophenyl)vinyl]-8-hydroxyquinoline) has been achieved with 95% yield, demonstrating the uniqueness of flow-type reactions.

From alcohol to 1,2,3-triazole via a multi-step continuous-flow synthesis of a rufinamide precursor

2016 ◽  
Vol 18 (18) ◽  
pp. 4947-4953 ◽  
Author(s):  
Svetlana Borukhova ◽  
Timothy Noël ◽  
Bert Metten ◽  
Eric de Vos ◽  
Volker Hessel
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Continuous Manufacturing ◽  
Flow Synthesis

Bringing the strongest suits of flow chemistry together to deliver the greenest possible process for continuous manufacturing of a rufinamide precursor.

Continuous Flow Synthesis of Organic Electronic Materials – Case Studies in Methodology Translation and Scale-up

2013 ◽  
Vol 66 (2) ◽  
pp. 151 ◽  
Author(s):  
Helga Seyler ◽  
Stefan Haid ◽  
Tae-Hyuk Kwon ◽  
David J. Jones ◽  
Peter Bäuerle ◽  
...  
Keyword(s):  
Continuous Flow ◽  
High Performance ◽  
Flow Reactor ◽  
Electronic Materials ◽  
Scale Up ◽  
Building Blocks ◽  
Organic Dye ◽  
Flow Synthesis ◽  
Organic Electronic Materials ◽  
Thiophene Derivatives

The continuous flow synthesis of functional thiophene derivatives was examined. Methodology for the lithiation of thiophene building blocks was developed using a commercial bench-top flow reactor. In addition, the advantages of flow processing were demonstrated in the synthesis of a high performance organic dye in gram scale.

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