New strategy for precise cancer therapy: tumor-specific delivery of mitochondria-targeting photodynamic therapy agents and in situ O2-generation in hypoxic tumors

2020 ◽  
Vol 8 (14) ◽  
pp. 3994-4002
Author(s):  
Huachao Chen ◽  
Chengkun He ◽  
Tianyi Chen ◽  
Xuling Xue
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
New Strategy ◽  
Mitochondria Targeting

This work reports new ROS-responsive and O2-producing nanoparticles to achieve selective and mitochondria-targeted PDT for cancer treatment against hypoxic tumors.

scholarly journals Photoactivatable dihydroalkaloids for cancer theranostics with AIE characteristics

2020 ◽  
Author(s):  
Xia Ling ◽  
Letao Huang ◽  
Youzhen Li ◽  
Qing Wan ◽  
Zhiming Wang ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Cancer Cells ◽  
Treatment Efficacy ◽  
Therapeutic Dose ◽  
Dehydrogenation Reaction ◽  
Precise Control ◽  
Image Guided ◽  
New Strategy ◽  
Cancer Theranostics

Chemotherapeutics with systemic administration usually suffer from low treatment efficacy and off-target toxicity. In contrary, the photoactivatable cancer theranostics can achieve image-guided precise control of therapeutic dose and location. However, the conventional photoactivatable chemotherapeutics usually require decoration of chemotherapeutics with additional photo-responsive groups through tedious synthetic procedures, which can lead to undesirable toxic byproducts and seriously restrict their applications. Herein, we propose a new strategy for photoactivatable caner theranostics based on photooxidative dehydrogenation reaction, which is only associating with water as the byproduct. To demonstrate the power of this strategy, we utilized the natural dihydrobenzo[c]phenanthridine alkaloids of DHCHE and DHSAN as photoactivatable theranostics to achieve selective imaging and killing of cancer cells by in situ transformation into nucleus-targeted CHE and SAN under light irradiation. Notably, CHE is featured with aggregation-induced emission (AIE) characteristics, which can be used for precise control of the photoactivatable therapeutic dose. This photoactivatable strategy based on dihydroalkaloids is thus promising for precise cancer treatment in clinic.<br>

scholarly journals Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review

2021 ◽  
Vol 9 ◽  
Author(s):  
Zeng Zeng ◽  
Chao Fang ◽  
Ying Zhang ◽  
Cong-Xian Chen ◽  
Yi-Feng Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Treatment ◽  
Therapeutic Agents ◽  
Sonodynamic Therapy ◽  
Therapeutic Modalities ◽  
Normal Functions ◽  
The Past ◽  
Highly Efficient ◽  
Apoptotic Pathways ◽  
Mitochondria Targeting

Mitochondria are the primary organelles which can produce adenosine triphosphate (ATP). They play vital roles in maintaining normal functions. They also regulated apoptotic pathways of cancer cells. Given that, designing therapeutic agents that precisely target mitochondria is of great importance for cancer treatment. Nanocarriers can combine the mitochondria with other therapeutic modalities in cancer treatment, thus showing great potential to cancer therapy in the past few years. Herein, we summarized lipophilic cation- and peptide-based nanosystems for mitochondria targeting. This review described how mitochondria-targeted nanocarriers promoted highly efficient cancer treatment in photodynamic therapy (PDT), chemotherapy, combined immunotherapy, and sonodynamic therapy (SDT). We further discussed mitochondria-targeted nanocarriers’ major challenges and future prospects in clinical cancer treatment.

scholarly journals Photoactivatable dihydroalkaloids for cancer theranostics with AIE characteristics

2020 ◽  
Author(s):  
Xia Ling ◽  
Letao Huang ◽  
Youzhen Li ◽  
Qing Wan ◽  
Zhiming Wang ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Cancer Cells ◽  
Treatment Efficacy ◽  
Therapeutic Dose ◽  
Dehydrogenation Reaction ◽  
Precise Control ◽  
Image Guided ◽  
New Strategy ◽  
Cancer Theranostics

Chemotherapeutics with systemic administration usually suffer from low treatment efficacy and off-target toxicity. In contrary, the photoactivatable cancer theranostics can achieve image-guided precise control of therapeutic dose and location. However, the conventional photoactivatable chemotherapeutics usually require decoration of chemotherapeutics with additional photo-responsive groups through tedious synthetic procedures, which can lead to undesirable toxic byproducts and seriously restrict their applications. Herein, we propose a new strategy for photoactivatable caner theranostics based on photooxidative dehydrogenation reaction, which is only associating with water as the byproduct. To demonstrate the power of this strategy, we utilized the natural dihydrobenzo[c]phenanthridine alkaloids of DHCHE and DHSAN as photoactivatable theranostics to achieve selective imaging and killing of cancer cells by in situ transformation into nucleus-targeted CHE and SAN under light irradiation. Notably, CHE is featured with aggregation-induced emission (AIE) characteristics, which can be used for precise control of the photoactivatable therapeutic dose. This photoactivatable strategy based on dihydroalkaloids is thus promising for precise cancer treatment in clinic.<br>

scholarly journals Clickable Amino acid Tuned Self-Assembly of Nucleus-selective Multi-component Nanoplatform for Synergistic Cancer Therapy

2021 ◽  
Author(s):  
Lan Yang ◽  
Xiao He ◽  
Zhiying Zeng ◽  
Jiakun Tang ◽  
Dongmei Qi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Targeted Therapy ◽  
Amino Acid ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Self Assembly ◽  
Great Promise ◽  
Application Potential

Nucleus-targeted therapy holds great promise in cancer treatment, however, a lack of effective nucleus-specific delivery significantly limits its application potential. Here, we report a nucleus-targeted synergistic chemo-photodynamic therapy based on...

Integrating in situ formation of nanozymes with three-dimensional dendritic mesoporous silica nanospheres for hypoxia-overcoming photodynamic therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (48) ◽  
pp. 22937-22945 ◽  
Author(s):  
Xiaoli Cai ◽  
Yanan Luo ◽  
Yang Song ◽  
Dong Liu ◽  
Hongye Yan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Three Dimensional ◽  
Silica Nanospheres ◽  
Highly Efficient ◽  
In Situ Formation ◽  
Mitochondria Targeting ◽  
Mesoporous Silica Nanospheres

A mitochondria-targeting and O2-evolving PDT nanoplatform based on 3D-dendritic MSNs was proposed for highly efficient cancer PDT treatment.

In situ oxygenating and 808 nm light-sensitized nanocomposite for multimodal imaging and mitochondria-assisted cancer therapy

2021 ◽  
Vol 9 (1) ◽  
pp. 131-146
Author(s):  
Arif Gulzar ◽  
Fei He ◽  
Aanisa Gulzar ◽  
Ye Kuang ◽  
Fangmei Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Multimodal Imaging ◽  
Elevated Level ◽  
Hypoxic Environment

The efficiency of photodynamic therapy (PDT) is severely constrained due to the innate hypoxic environment, besides the elevated level of glutathione (GSH).

scholarly journals Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment

2021 ◽  
Vol 10 ◽  
Author(s):  
Waleska K. Martins ◽  
Renata Belotto ◽  
Maryana N. Silva ◽  
Daniel Grasso ◽  
Maynne D. Suriani ◽  
...  
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Tumor Cells ◽  
Molecular Mechanisms ◽  
Light Sources ◽  
Regulated Cell Death ◽  
Age Related ◽  
Cell Death Mechanisms

Cancer is considered an age-related disease that, over the next 10 years, will become the most prevalent health problem worldwide. Although cancer therapy has remarkably improved in the last few decades, novel treatment concepts are needed to defeat this disease. Photodynamic Therapy (PDT) signalize a pathway to treat and manage several types of cancer. Over the past three decades, new light sources and photosensitizers (PS) have been developed to be applied in PDT. Nevertheless, there is a lack of knowledge to explain the main biochemical routes needed to trigger regulated cell death mechanisms, affecting, considerably, the scope of the PDT. Although autophagy modulation is being raised as an interesting strategy to be used in cancer therapy, the main aspects referring to the autophagy role over cell succumbing PDT-photoinduced damage remain elusive. Several reports emphasize cytoprotective autophagy, as an ultimate attempt of cells to cope with the photo-induced stress and to survive. Moreover, other underlying molecular mechanisms that evoke PDT-resistance of tumor cells were considered. We reviewed the paradigm about the PDT-regulated cell death mechanisms that involve autophagic impairment or boosted activation. To comprise the autophagy-targeted PDT-protocols to treat cancer, it was underlined those that alleviate or intensify PDT-resistance of tumor cells. Thereby, this review provides insights into the mechanisms by which PDT can be used to modulate autophagy and emphasizes how this field represents a promising therapeutic strategy for cancer treatment.

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