Cancer‐Cell‐Activated In‐Situ Synthesis of Mitochondria‐Targeting AIE Photosensitizer for Precise Photodynamic Therapy

2021 ◽  
Author(s):  
Yuanbo Wang ◽  
Shidang Xu ◽  
Leilei Shi ◽  
Cathleen Teh ◽  
Guobin Qi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
In Situ Synthesis ◽  
Mitochondria Targeting

In situ formation of large pore silica–MnO2 nanocomposites with H+/H2O2 sensitivity for O2-elevated photodynamic therapy and potential MR imaging

2018 ◽  
Vol 54 (24) ◽  
pp. 2962-2965 ◽  
Author(s):  
Zhimei He ◽  
Yan Xiao ◽  
Jian-Rong Zhang ◽  
Penghui Zhang ◽  
Jun-Jie Zhu
Keyword(s):  
Photodynamic Therapy ◽  
Mr Imaging ◽  
Cancer Cell ◽  
Tumor Hypoxia ◽  
Large Pore ◽  
In Situ Formation

Endogenous H+-/H2O2-triggered nanohybrids for cancer cell-specific and O2 self-sufficient PDT: a promising platform for effective PDT against tumor hypoxia.

scholarly journals Photodynamic Therapy Induced Cell Death Mechanisms in Breast Cancer

2021 ◽  
Vol 22 (19) ◽  
pp. 10506
Author(s):  
Dimakatso R. Mokoena ◽  
Blassan P. George ◽  
Heidi Abrahamse
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Cell ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Normal Cells ◽  
Cell Death Mechanisms

Breast cancer is the second most common cancer globally and the pioneering cause of mortality among women. It usually begins from the ducts or lobules, referred to as ductal carcinoma in situ, or lobular carcinoma in situ. Age, mutations in Breast Cancer Gene 1 or 2 (BRCA1 or BRCA2) genes, and dense breast tissue are the highest risk factors. Current treatments are associated with various side effects, relapse, and a low quality of life. Although conventional treatments, such as surgery and chemotherapy, have been used for decades, their adverse side effects on normal cells and tissues pose a major weakness, which calls for a non-invasive treatment option. Photodynamic therapy (PDT) has proven to be a promising form of cancer therapy. It is less invasive, target-specific, and with reduced cytotoxicity to normal cells and tissues. It involves the use of a photosensitizer (PS) and light at a specific wavelength to produce reactive oxygen species. One of the reasons for the target specificity is associated with the dense vascularization of cancer tissues, which tends to increase the surface area for the PS uptake. Photosensitizers are light-sensitive molecules, which result in cancer cell destruction followed by light irradiation. Depending on the localization of the PS within the cancer cell, its destruction may be via apoptosis, necrosis, or autophagy. This review focuses on the breast cancer etiopathology and PDT-induced cell death mechanisms in breast cancer cells.

Integrating in situ formation of nanozymes with three-dimensional dendritic mesoporous silica nanospheres for hypoxia-overcoming photodynamic therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (48) ◽  
pp. 22937-22945 ◽  
Author(s):  
Xiaoli Cai ◽  
Yanan Luo ◽  
Yang Song ◽  
Dong Liu ◽  
Hongye Yan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Three Dimensional ◽  
Silica Nanospheres ◽  
Highly Efficient ◽  
In Situ Formation ◽  
Mitochondria Targeting ◽  
Mesoporous Silica Nanospheres

A mitochondria-targeting and O2-evolving PDT nanoplatform based on 3D-dendritic MSNs was proposed for highly efficient cancer PDT treatment.

Cancer cell-targeted nanoprobe for multilayer imaging of diverse biomarkers and precise photodynamic therapy

2020 ◽  
Vol 56 (96) ◽  
pp. 15208-15211
Author(s):  
Zhuolin Fu ◽  
Yingdi Wu ◽  
Chunnian Ren ◽  
Weiling Song ◽  
Xiaoru Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Cancer Biomarkers ◽  
Muc1 Mucin ◽  
Multifunctional Nanoprobe

A novel multifunctional nanoprobe was designed for cancer cell targeted multilayer imaging of two cancer biomarkers. And in situ imaging of membrane MUC1 mucin and cytoplasmic microRNA miR-21 coupled with precise photodynamic therapy was achieved.

New strategy for precise cancer therapy: tumor-specific delivery of mitochondria-targeting photodynamic therapy agents and in situ O2-generation in hypoxic tumors

2020 ◽  
Vol 8 (14) ◽  
pp. 3994-4002
Author(s):  
Huachao Chen ◽  
Chengkun He ◽  
Tianyi Chen ◽  
Xuling Xue
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
New Strategy ◽  
Mitochondria Targeting

This work reports new ROS-responsive and O2-producing nanoparticles to achieve selective and mitochondria-targeted PDT for cancer treatment against hypoxic tumors.

Hydrothermal In Situ Synthesis ZnO Nanoarrays and Their Photocatalytic Applications

2013 ◽  
Vol 30 (6) ◽  
pp. 667
Author(s):  
Zhenzhen WANG ◽  
Fangfang LI ◽  
Han GUO ◽  
Jiuju FENG ◽  
Aijun WANG
Keyword(s):  
In Situ Synthesis ◽  
Photocatalytic Applications

In situ synthesis of SiC nanowire porous layer on carbon/carbon composites

2017 ◽  
Vol 101 (3) ◽  
pp. 1371-1380 ◽  
Author(s):  
Tao Li ◽  
Yulei Zhang ◽  
Jia Sun ◽  
Jincui Ren ◽  
Pengfei Zhang ◽  
...  
Keyword(s):  
Porous Layer ◽  
In Situ Synthesis ◽  
Carbon Composites

In situ synthesis of Mn3O4/graphene nanocomposite and its application as a lubrication additive at high temperatures

2021 ◽  
Vol 546 ◽  
pp. 149019
Author(s):  
Bao Jin ◽  
Jun Zhao ◽  
Guangyan Chen ◽  
Yongyong He ◽  
Yiyao Huang ◽  
...  
Keyword(s):  
High Temperatures ◽  
In Situ Synthesis ◽  
Graphene Nanocomposite ◽  
Lubrication Additive
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