scholarly journals Genome mining and biosynthesis of kitacinnamycins as a STING activator

2019 ◽  
Vol 10 (18) ◽  
pp. 4839-4846 ◽  
Author(s):  
Jing Shi ◽  
Cheng Li Liu ◽  
Bo Zhang ◽  
Wen Jie Guo ◽  
Jiapeng Zhu ◽  
...  
Keyword(s):  
Genome Mining ◽  
Type Ii ◽  
Unique Type ◽  
Type Ii Pks

Genome mining targeting unique type II PKS and NRPS led to the identification of a novel class of glycopeptides named kitacinnamycins.

scholarly journals A unique type II restriction endonuclease fromAcinetobacter twoffiN

1987 ◽  
Vol 15 (17) ◽  
pp. 7201-7201 ◽  
Author(s):  
Richard D. Morgan ◽  
Michael Dalton ◽  
Robert Stote
Keyword(s):  
Restriction Endonuclease ◽  
Type Ii ◽  
Unique Type

A type-II C2N/α-Te van der Waals heterojunction with improved optical properties by external perturbation

2019 ◽  
Vol 21 (39) ◽  
pp. 21753-21760 ◽  
Author(s):  
Zhuang Ma ◽  
Yusheng Wang ◽  
Yuting Wei ◽  
Chong Li ◽  
Xiuwen Zhang ◽  
...  
Keyword(s):  
Optical Properties ◽  
Optical Absorption ◽  
Broad Spectrum ◽  
Near Infrared ◽  
External Perturbation ◽  
Band Alignment ◽  
Type Ii ◽  
Unique Type ◽  
Spectrum Width ◽  
Tunable Band Gap

The C2N/α-Te vdW heterojunction possessed a unique type-II band alignment, tunable band gap, improved optical absorption strength, and broad spectrum width (ultraviolet to near-infrared).

Cloning and Heterologous Expression of Three Type II PKS Gene Clusters fromStreptomyces bottropensis

ChemBioChem ◽  
2011 ◽  
Vol 13 (2) ◽  
pp. 224-230 ◽  
Author(s):  
Xiaohui Yan ◽  
Katharina Probst ◽  
Anton Linnenbrink ◽  
Moritz Arnold ◽  
Thomas Paululat ◽  
...  
Keyword(s):  
Heterologous Expression ◽  
Gene Clusters ◽  
Type Ii ◽  
Type Ii Pks

Post Polyketide Synthase Carbon–Carbon Bond Formation in Type-II PKS-Derived Natural Products fromStreptomyces venezuelae

2018 ◽  
Vol 83 (4) ◽  
pp. 1876-1890 ◽  
Author(s):  
Andrew W. Robertson ◽  
Jeanna M. MacLeod ◽  
Logan W. MacIntyre ◽  
Stephanie. M. Forget ◽  
Steven R. Hall ◽  
...  
Keyword(s):  
Natural Products ◽  
Polyketide Synthase ◽  
Bond Formation ◽  
Type Ii ◽  
Carbon Bond ◽  
Carbon Carbon Bond ◽  
Type Ii Pks

scholarly journals Ketide Synthase (KS) Domain Prediction and Analysis of Iterative Type II PKS Gene in Marine Sponge-Associated Actinobacteria Producing Biosurfactants and Antimicrobial Agents

2016 ◽  
Vol 7 ◽  
Author(s):  
Joseph Selvin ◽  
Ganesan Sathiyanarayanan ◽  
Anuj N. Lipton ◽  
Naif Abdullah Al-Dhabi ◽  
Mariadhas Valan Arasu ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Antimicrobial Agents ◽  
Type Ii ◽  
Domain Prediction ◽  
Type Ii Pks

scholarly journals Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases

ChemBioChem ◽  
2018 ◽  
Vol 19 (16) ◽  
pp. 1727-1733 ◽  
Author(s):  
Liao-Bin Dong ◽  
Jeffrey D. Rudolf ◽  
Ming-Rong Deng ◽  
Xiaohui Yan ◽  
Ben Shen
Keyword(s):  
Genome Mining ◽  
Type Ii ◽  
Bacterial Type ◽  
Diterpene Synthases

scholarly journals New insights into bacterial type II polyketide biosynthesis

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 172 ◽  
Author(s):  
Zhuan Zhang ◽  
Hai-Xue Pan ◽  
Gong-Li Tang
Keyword(s):  
Biological Activities ◽  
Genome Mining ◽  
Large Family ◽  
Combinatorial Biosynthesis ◽  
Type Ii ◽  
Polyketide Biosynthesis ◽  
Aromatic Polyketides ◽  
Starting Point ◽  
Biosynthetic Engineering ◽  
Bacterial Type

Bacterial aromatic polyketides, exemplified by anthracyclines, angucyclines, tetracyclines, and pentangular polyphenols, are a large family of natural products with diverse structures and biological activities and are usually biosynthesized by type II polyketide synthases (PKSs). Since the starting point of biosynthesis and combinatorial biosynthesis in 1984–1985, there has been a continuous effort to investigate the biosynthetic logic of aromatic polyketides owing to the urgent need of developing promising therapeutic candidates from these compounds. Recently, significant advances in the structural and mechanistic identification of enzymes involved in aromatic polyketide biosynthesis have been made on the basis of novel genetic, biochemical, and chemical technologies. This review highlights the progress in bacterial type II PKSs in the past three years (2013–2016). Moreover, novel compounds discovered or created by genome mining and biosynthetic engineering are also included.

scholarly journals Genome-based analysis of the type II PKS biosynthesis pathway of xanthones in Streptomyces caelestis and their antifungal activity

RSC Advances ◽  
2019 ◽  
Vol 9 (64) ◽  
pp. 37376-37383
Author(s):  
Ling-Li Liu ◽  
Hong-Fei Liu ◽  
Hua-Hua Gao ◽  
Zheng-Zhong Yang ◽  
Xiao-Lan Feng ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Pathogenic Fungi ◽  
Plant Pathogenic Fungi ◽  
Type Ii ◽  
Biosynthesis Pathway ◽  
Antifungal Activities ◽  
Liquid Fermentation ◽  
Type Ii Pks

The ethyl acetate extract from the liquid fermentation of S. caelestis Aw99c exhibited high and broad antifungal activities against plant pathogenic fungi.

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