scholarly journals Theoretical and experimental studies of an oseltamivir–triazole-based thermoresponsive organogel

RSC Advances ◽  
2019 ◽  
Vol 9 (36) ◽  
pp. 21031-21041 ◽  
Author(s):  
Sumit Kumar ◽  
Lidong Wu ◽  
Neha Sharma ◽  
Ayushee Ayushee ◽  
Kumar Kaushik ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Experimental Studies ◽  
Low Molecular Weight ◽  
Sensing Technology ◽  
Significant Interest ◽  
Potential Applications

Low-molecular weight organic gelators have been of significant interest in recent years because of their interesting properties and potential applications in sensing technology, biomedicine and drug delivery.

A Hydrogel-based Implantable Multidrug Antitubercular Formulation Outperforms Oral Delivery.

Nanoscale ◽  
2021 ◽  
Author(s):  
Sanjay Pal ◽  
Vijay Soni ◽  
Sandeep Kumar ◽  
Somesh K Jha ◽  
Nihal Medatwal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Delivery ◽  
Low Molecular Weight ◽  
Front Line ◽  
Antitubercular Drugs

We present a non-immunogenic, injectable, low molecular weight, amphiphilic hydrogel-based drug delivery system (TB-Gel) that can entrap a cocktail of four front-line antitubercular drugs isoniazid, rifampicin, pyrazinamide, and ethambutol. We...

Structure and Electrical Properties of an Assembly of Au Nanoclusters

2001 ◽  
Vol 635 ◽  
Author(s):  
G. Muralidharan ◽  
L. Maya ◽  
T. Thundat
Keyword(s):  
Threshold Voltage ◽  
Specific Reference ◽  
Low Molecular Weight ◽  
Electrical Measurements ◽  
Monolayer Films ◽  
Au Nanoclusters ◽  
Fundamental Physics ◽  
Au Clusters ◽  
Significant Interest ◽  
Potential Applications

AbstractConduction through an assembly of nanosized clusters coupled by tunneling barriers is of significant interest both for understanding the fundamental physics involved and for potential applications. In this study, we describe a technique for preparing relatively large (dimensions of a few 100 µm to a few mm in size) monolayer films consisting of 3 nm diameter Au clusters coated with mercaptododecanoic acid, using low molecular weight-polymers as coupling agents. Electrical measurements of the assembly show non-linear characteristics. Below a certain threshold voltage, the current does not vary with an increase in voltage. Above this threshold voltage, current increases with voltage and can be described by a power-law relationship with an exponent close to unity. These characteristics of the I-V curve are discussed with specific reference to theoretical studies on conduction through an array of capacitance-coupled metallic islands and previous experimental results in similar systems.

Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery

2009 ◽  
Vol 379 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Ning Li ◽  
Chunyang Zhuang ◽  
Mi Wang ◽  
Xiyang Sun ◽  
Shufang Nie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Ocular Drug Delivery ◽  
Low Molecular Weight ◽  
Low Molecular Weight Chitosan ◽  
Potential Use

Stimuli Responsive Self-Assembled Hydrogel of a Low Molecular Weight Free Dipeptide with Potential for Tunable Drug Delivery

2008 ◽  
Vol 9 (8) ◽  
pp. 2244-2250 ◽  
Author(s):  
Jiban J. Panda ◽  
Aseem Mishra ◽  
Atanu Basu ◽  
Virander S. Chauhan
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Low Molecular Weight ◽  
Stimuli Responsive ◽  
Self Assembled

Clinical And Experimental Studies On FBG Heterogeneity And Fibrinogenolysis —Especially In DIC And UK Treatment

1981 ◽  
Author(s):  
M Yamauchi ◽  
H Takei ◽  
T Seya ◽  
Y Oguma ◽  
T Murakoshi ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Fibrinolytic Activity ◽  
Experimental Studies ◽  
Experimental Models ◽  
Low Molecular Weight ◽  
Electrophoretic Patterns ◽  
Sds Page ◽  
Cirrhotic Patients ◽  
Partial Degradation

ABy means of SDS-PAGE (3.3% gel), Fbg heterogeneity originated from partial degradation of Aα chain was studied. Comparison of electrophoretic patterns of plasma and corresponding serum made it possible to identify 2 major Fbg bands designated as high-molecular-weight Fbg (HMW, MW 350,000) and low-molecular-weight Fbg (LMW, MW 310,000). LMW comprised 28×2% (mean×S.D) of total Fbg (HMW+LMW) in healty subjects. The elevation of fibrinolytic activity did not accompany the increase of percentages of LMW in various diseases, even in cirrhotic patients whose levels of α2;PI were low. In DIC patients percentages of LMW were decreased extremely (12×6%, mean×SD). Samples from animal experimental models of DIC exhibited the same pattern of Fbg heterogeneity as that of DIC patients.UK was added to the purified Fbg in vitro. On the earliest stage of the fibrinogenolysis. 2 bands appeared newly on SDS-PAGE, while the bands of HMW and LMW were decreased. One of these new bands (Band 1) corresponded with a major compornent of Fraction 1-9 of Mosesson. It was located in the slightly anodal position (MW 300,000) from LMW band. Another band (MW 270,000) migrated between Band 1 and the band of Frag X. The same pattern of Fbg heterogeneity was observed in patients recieving large dose of UK. After cessation of UK treatment these new bands disappeared, while the bands of HMW was increased extremelThese findings suggest that HMW is a freshly synthesized Fbg and that unknown mechanism without plasmin may present for the conversion HMW to LMW.

scholarly journals Progress in Microneedle-Mediated Protein Delivery

2020 ◽  
Vol 9 (2) ◽  
pp. 542 ◽  
Author(s):  
Rezvan Jamaledin ◽  
Concetta Di Natale ◽  
Valentina Onesto ◽  
Zahra Taraghdari ◽  
Ehsan Zare ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Stratum Corneum ◽  
Transdermal Drug Delivery ◽  
Protein Delivery ◽  
Scaling Up ◽  
Low Molecular Weight ◽  
Non Invasive ◽  
Promising Tool ◽  
Transdermal Patches

The growing demand for patient-compliance therapies in recent years has led to the development of transdermal drug delivery, which possesses several advantages compared with conventional methods. Delivering protein through the skin by transdermal patches is extremely difficult due to the presence of the stratum corneum which restricts the application to lipophilic drugs with relatively low molecular weight. To overcome these limitations, microneedle (MN) patches, consisting of micro/miniature-sized needles, are a promising tool to perforate the stratum corneum and to release drugs and proteins into the dermis following a non-invasive route. This review investigates the fabrication methods, protein delivery, and translational considerations for the industrial scaling-up of polymeric MNs for dermal protein delivery.

scholarly journals Production of road oil bitumens by the method of chemical modification of oil residues.

2021 ◽  
Vol 4 ◽  
pp. 21-27
Author(s):  
V.М. Gunka ◽  
Yu.V. Prysiazhnyi ◽  
Yu.Ya. Demchuk ◽  
Yu.M. Hrynchuk ◽  
Yu.V. Sidun ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Chemical Modification ◽  
Experimental Studies ◽  
Softening Temperature ◽  
Quality Characteristics ◽  
Low Molecular Weight ◽  
Organic Substances ◽  
Needle Penetration ◽  
Oil Residue ◽  
Process Factors

PRODUCTION OF ROAD OIL BITUMENS BY THE METHOD OF CHEMICAL MODIFICATION OF OIL RESIDUES © V.М. Gunka, PhD in technical sciences, Yu.V. Prysiazhnyi, PhD in technical sciences, Yu.Ya. Demchuk, PhD in technical sciences, Yu.M. Hrynchuk, PhD in technical sciences, Yu.V. Sidun, PhD in technical sciences, M.M. Bratychak, Doctor of Chemical Sciences (Lviv Polytechnic Naional University, 12 Stepan Bandera Str., 79013, Lviv, Ukraine) The article is devoted to obtaining road oil bitumen from oil residues by modifying them with relatively cheap low molecular weight organic substances. The proposed method relates to a chemical modification, which, in case of its industrial implementation, will allow avoiding the use of expensive physical modifiers. A 37 % aqueous solution of formaldehyde was used as low molecular weight organic substances (modifier / chemical reagent of the process) for chemical modification of tar; concentrated sulfuric acid (H2SO4) was used as a catalyst for the chemical modification of tar. As a feedstock for chemical modification, we used an oil residue - tar, selected at PJSC “Ukrtatnafta” (Kremenchug, Ukraine). The chemical modification with formaldehyde was carried out in hermetic stationary containers capable of operating under excess pressure. The photographs of the equipment are given. Since the ultimate goal of the work was to obtain road oil bitumen, then, analyzing the results of experimental studies, we focused on the quality characteristics of this particular product. At the same time, the most important quality indicators were determined, namely: the depth of needle penetration, softening temperature, ductility (extensibility), adhesion to glass (adhesion to glass), Fraas brittle temperature, penetration index. For tar, the following characteristics such as density, flash point in an open crucible, and a boiling point were additionally determined. As a result of the experiments, the fundamental possibility of obtaining road oil bitumen by the method of chemical modification of tar with formaldehyde was established. It was revealed that the process factors (formaldehyde content in the reaction mixture, catalyst content in the reaction mixture, temperature and duration) have a significant effect on the quality of the resulting product. Changing their values allows you to adjust the values of the quality characteristics of the resulting bitumen. Keywords: binders, bitumen, oil residue, modification. Corresponding author V.М. Gunka, e-mail: [email protected]

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