scholarly journals Progress in Microneedle-Mediated Protein Delivery

2020 ◽  
Vol 9 (2) ◽  
pp. 542 ◽  
Author(s):  
Rezvan Jamaledin ◽  
Concetta Di Natale ◽  
Valentina Onesto ◽  
Zahra Taraghdari ◽  
Ehsan Zare ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Stratum Corneum ◽  
Transdermal Drug Delivery ◽  
Protein Delivery ◽  
Scaling Up ◽  
Low Molecular Weight ◽  
Non Invasive ◽  
Promising Tool ◽  
Transdermal Patches

The growing demand for patient-compliance therapies in recent years has led to the development of transdermal drug delivery, which possesses several advantages compared with conventional methods. Delivering protein through the skin by transdermal patches is extremely difficult due to the presence of the stratum corneum which restricts the application to lipophilic drugs with relatively low molecular weight. To overcome these limitations, microneedle (MN) patches, consisting of micro/miniature-sized needles, are a promising tool to perforate the stratum corneum and to release drugs and proteins into the dermis following a non-invasive route. This review investigates the fabrication methods, protein delivery, and translational considerations for the industrial scaling-up of polymeric MNs for dermal protein delivery.

scholarly journals Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Yi-Qun Yu ◽  
Xue Yang ◽  
Xiao-Fang Wu ◽  
Yi-Bin Fan
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Hydrophilic Drugs ◽  
Non Invasive ◽  
Drug Molecules ◽  
Systemic Side Effects ◽  
Route Of Delivery ◽  
Transdermal Route

The transdermal route of administration provides numerous advantages over conventional routes i.e., oral or injectable for the treatment of different diseases and cosmetics applications. The skin also works as a reservoir, thus deliver the penetrated drug for more extended periods in a sustained manner. It reduces toxicity and local irritation due to multiple sites for absorption and owes the option of avoiding systemic side effects. However, the transdermal route of delivery for many drugs is limited since very few drugs can be delivered at a viable rate using this route. The stratum corneum of skin works as an effective barrier, limiting most drugs’ penetration posing difficulty to cross through the skin. Fortunately, some non-invasive methods can significantly enhance the penetration of drugs through this barrier. The use of nanocarriers for increasing the range of available drugs for the transdermal delivery has emerged as a valuable and exciting alternative. Both the lipophilic and hydrophilic drugs can be delivered via a range of nanocarriers through the stratum corneum with the possibility of having local or systemic effects to treat various diseases. In this review, the skin structure and major obstacle for transdermal drug delivery, different nanocarriers used for transdermal delivery, i.e., nanoparticles, ethosomes, dendrimers, liposomes, etc., have been discussed. Some recent examples of the combination of nanocarrier and physical methods, including iontophoresis, ultrasound, laser, and microneedles, have also been discussed for improving the therapeutic efficacy of transdermal drugs. Limitations and future perspectives of nanocarriers for transdermal drug delivery have been summarized at the end of this manuscript.

scholarly journals Enhancement strategies for transdermal drug delivery systems: current trends and applications

2021 ◽  
Author(s):  
Delly Ramadon ◽  
Maeliosa T. C. McCrudden ◽  
Aaron J. Courtenay ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Global Market ◽  
Therapeutic Drug ◽  
Current Trends ◽  
Transdermal Drug Delivery Systems

AbstractTransdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

A Hydrogel-based Implantable Multidrug Antitubercular Formulation Outperforms Oral Delivery.

Nanoscale ◽  
2021 ◽  
Author(s):  
Sanjay Pal ◽  
Vijay Soni ◽  
Sandeep Kumar ◽  
Somesh K Jha ◽  
Nihal Medatwal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Delivery ◽  
Low Molecular Weight ◽  
Front Line ◽  
Antitubercular Drugs

We present a non-immunogenic, injectable, low molecular weight, amphiphilic hydrogel-based drug delivery system (TB-Gel) that can entrap a cocktail of four front-line antitubercular drugs isoniazid, rifampicin, pyrazinamide, and ethambutol. We...

scholarly journals COMPARATIVE EVALUATION OF SELECTED POLYMERS AND PLASTICIZER ON TRANSDERMAL DRUG DELIVERY SYSTEM

2018 ◽  
Vol 10 (1) ◽  
pp. 67
Author(s):  
Bhawana Sethi ◽  
Rupa Mazumder
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Propylene Glycol ◽  
Drug Delivery System ◽  
Transdermal Drug Delivery ◽  
Release Kinetics ◽  
Content Uniformity ◽  
Transdermal Drug Delivery System ◽  
Transdermal Patches

Objective: The present work was aimed at preparation of transdermal patches by a solvent casting method using a varying concentration of polymers i.e. methocel (K15 and K100), ethocel (4 and 10), gelatin, chitosan, eudragit (RL and RS) grade using plasticizer (glycerin and propylene glycol).Methods: The ratio of drug to polymers and plasticizer was varied and the effect of formulation variables was studied. Prepared transdermal patches were evaluated for physicochemical properties, in-vitro permeation studies, content uniformity, primary skin irritation studies and FT-IR studies.Results: The formulated transdermal patch by using Methocel K 100 M showed good physical properties. The average weight of patches prepared using glycerin as a plasticizer were ranged from 42.33-67.00 mg and propylene glycol as a plasticizer were ranged from 40.67-67.67 mg. The percentage moisture absorption varies from 1.76 to 10.73 for patches formulated using glycerin and 2.28 to 7.97 for propylene glycol patches. The percentage moisture loss from patches prepared using glycerin was ranged from 2.75 to 11.54 and 2.87 to 12.02 from propylene glycol. The water vapour transmission rate from patches prepared using glycerin was ranged from 0.25 to 0.92 and 0.41 to 1.76. The formulated patch showed the acceptable quantity of medicament ranged from (100.20-101.05%). This result met the test content uniformity as per BP (85% to 115%). According to that, the drug was consistent throughout the patches. The formulation PGD is considered as the best formulation, since it shows a maximum in vitro drug release as 43.75 % at 24 h. The drug release kinetics studied showed that the majority of formulations was following zero order.Conclusion: In conclusion, controlled release transdermal drug delivery system patches of aliskiren can be prepared using polymer combinations, with a different plasticizer. The release rate of drug depends upon the polymer. However, release kinetics followed zero order.

Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery

2009 ◽  
Vol 379 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Ning Li ◽  
Chunyang Zhuang ◽  
Mi Wang ◽  
Xiyang Sun ◽  
Shufang Nie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Ocular Drug Delivery ◽  
Low Molecular Weight ◽  
Low Molecular Weight Chitosan ◽  
Potential Use
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