scholarly journals Immobilized thermolysin for highly efficient production of low-molecular-weight protamine-An attractive cell-penetrating peptide for macromolecular drug delivery applications

2011 ◽  
Vol 100A (1) ◽  
pp. 211-219 ◽  
Author(s):  
Allan E. David ◽  
Junbo Gong ◽  
Beata Chertok ◽  
Roman C. Domszy ◽  
Cheol Moon ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Cell Penetrating Peptide ◽  
Low Molecular Weight ◽  
Efficient Production ◽  
Highly Efficient ◽  
Cell Penetrating ◽  
Drug Delivery Applications ◽  
Macromolecular Drug Delivery ◽  
Macromolecular Drug

Studies towards improved cell-penetrating peptide-promoted macromolecular drug delivery

2010 ◽  
Vol 15 (23-24) ◽  
pp. 1109-1109
Author(s):  
Jacob A.D. Clausen ◽  
Lars Linderoth ◽  
Rikke Bjerring Andersen ◽  
Henrik Franzyk ◽  
Hanne M. Nielsen
Keyword(s):  
Drug Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Macromolecular Drug Delivery ◽  
Macromolecular Drug

Low molecular weight protamine (LMWP): A nontoxic protamine substitute and an effective cell-penetrating peptide

2014 ◽  
Vol 193 ◽  
pp. 63-73 ◽  
Author(s):  
Huining He ◽  
Junxiao Ye ◽  
Ergang Liu ◽  
Qiuling Liang ◽  
Quan Liu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Cell Penetrating Peptide ◽  
Low Molecular Weight ◽  
Cell Penetrating

The systemic delivery of siRNAs by a cell penetrating peptide, low molecular weight protamine

Biomaterials ◽  
2010 ◽  
Vol 31 (6) ◽  
pp. 1429-1443 ◽  
Author(s):  
Young-Suk Choi ◽  
Jue Yeon Lee ◽  
Jin Sook Suh ◽  
Young-Min Kwon ◽  
Seung-Jin Lee ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Cell Penetrating Peptide ◽  
Low Molecular Weight ◽  
Systemic Delivery ◽  
Cell Penetrating ◽  
A Cell

scholarly journals Highly Efficient Synthesis of Type B Gelatin and Low Molecular Weight Chitosan Nanoparticles: Potential Applications as Bioactive Molecule Carriers and Cell-Penetrating Agents

Polymers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 4078
Author(s):  
Cristina Gonzalez-Melo ◽  
Andres J. Garcia-Brand ◽  
Valentina Quezada ◽  
Luis H. Reyes ◽  
Carolina Muñoz-Camargo ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Chitosan Nanoparticles ◽  
Synthesis Method ◽  
Low Molecular Weight ◽  
Type B ◽  
Efficient Synthesis ◽  
Gelatin Nanoparticles ◽  
Highly Efficient ◽  
Cell Penetrating ◽  
Bioactive Molecule

Gelatin and chitosan nanoparticles have been widely used in pharmaceutical, biomedical, and nanofood applications due to their high biocompatibility and biodegradability. This study proposed a highly efficient synthesis method for type B gelatin and low-molecular-weight (LMW) chitosan nanoparticles. Gelatin nanoparticles (GNPs) were synthesized by the double desolvation method and the chitosan nanoparticles (CNPs) by the ionic gelation method. The sizes of the obtained CNPs and GNPs (373 ± 71 nm and 244 ± 67 nm, respectively) and zeta potential (+36.60 ± 3.25 mV and −13.42 ± 1.16 mV, respectively) were determined via dynamic light scattering. Morphology and size were verified utilizing SEM and TEM images. Finally, their biocompatibility was tested to assure their potential applicability as bioactive molecule carriers and cell-penetrating agents.

Interactions governing the entrapment of anticancer drugs by low-molecular-weight hydrogelator for drug delivery applications

RSC Advances ◽  
2016 ◽  
Vol 6 (24) ◽  
pp. 19751-19757 ◽  
Author(s):  
Siddhi Gupta ◽  
Manish Singh ◽  
Amarendar Reddy M. ◽  
Prabhu S. Yavvari ◽  
Aasheesh Srivastava ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Anticancer Drugs ◽  
Small Molecule ◽  
Low Molecular Weight ◽  
Drug Encapsulation ◽  
Drug Delivery Applications

We present the effect of size, charge, and hydrophobicity of anticancer drugs on their drug encapsulation efficacy in anl-alanine-based small-molecule hydrogelator.

Core-multishell nanotransporters enhance skin penetration of the cell-penetrating peptide low molecular weight protamine

2014 ◽  
Vol 25 (11) ◽  
pp. 1337-1341 ◽  
Author(s):  
Nhung Do ◽  
Günther Weindl ◽  
Emanuel Fleige ◽  
Mario Salwiczek ◽  
Beate Koksch ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Skin Penetration ◽  
Cell Penetrating Peptide ◽  
Low Molecular Weight ◽  
Cell Penetrating

Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties

2014 ◽  
Vol 12 (10) ◽  
pp. 1652-1663 ◽  
Author(s):  
Marta Soler ◽  
Marta González-Bártulos ◽  
David Soriano-Castell ◽  
Xavi Ribas ◽  
Miquel Costas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Cellular Uptake ◽  
Therapeutic Agents ◽  
Cell Penetrating Peptide ◽  
Highly Efficient ◽  
Cell Penetrating ◽  
Efficient Vector

BP16is a non-toxic cell-penetrating peptide with high cellular uptakein vitro. This peptide is an efficient vector for the delivery of therapeutic agents into cells, as has been shown for the anticancer drug chlorambucil.

A Hydrogel-based Implantable Multidrug Antitubercular Formulation Outperforms Oral Delivery.

Nanoscale ◽  
2021 ◽  
Author(s):  
Sanjay Pal ◽  
Vijay Soni ◽  
Sandeep Kumar ◽  
Somesh K Jha ◽  
Nihal Medatwal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Delivery ◽  
Low Molecular Weight ◽  
Front Line ◽  
Antitubercular Drugs

We present a non-immunogenic, injectable, low molecular weight, amphiphilic hydrogel-based drug delivery system (TB-Gel) that can entrap a cocktail of four front-line antitubercular drugs isoniazid, rifampicin, pyrazinamide, and ethambutol. We...

Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery

2009 ◽  
Vol 379 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Ning Li ◽  
Chunyang Zhuang ◽  
Mi Wang ◽  
Xiyang Sun ◽  
Shufang Nie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Ocular Drug Delivery ◽  
Low Molecular Weight ◽  
Low Molecular Weight Chitosan ◽  
Potential Use
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