Synthesis, structural characterisation, and cytotoxicity studies of Bi, W, and Mo containing homo- and hetero-bimetallic polyoxometalates

2019 ◽  
Vol 48 (42) ◽  
pp. 15962-15969 ◽  
Author(s):  
Dimuthu C. Senevirathna ◽  
Melissa V. Werrett ◽  
Manja Kubeil ◽  
Holger Stephan ◽  
Philip C. Andrews
Keyword(s):  
Water Soluble ◽  
Embryonic Cells ◽  
Human Carcinoma ◽  
Structural Characterisation ◽  
Cytotoxicity Studies ◽  
Low Toxicity

High nuclearity, water soluble polyoxometalates composed of high Z number metals W, Mo and Bi demonstrate low toxicity to human carcinoma and healthy embryonic cells and their potential as radiosensitisers.

scholarly journals Preparation, Cytotoxicity, and In Vitro Bioimaging of Water Soluble and Highly Fluorescent Palladium Nanoclusters

2020 ◽  
Vol 7 (1) ◽  
pp. 20 ◽  
Author(s):  
Suresh Thangudu ◽  
Poliraju Kalluru ◽  
Raviraj Vankayala
Keyword(s):  
In Vitro Cytotoxicity ◽  
Molecular Probes ◽  
Water Soluble ◽  
Quantum Yields ◽  
Cell Labelling ◽  
Metal Nanoclusters ◽  
Extinction Coefficients ◽  
Cytotoxicity Studies

Fluorescent probes offer great potential to identify and treat surgical tumors by clinicians. To this end, several molecular probes were examined as in vitro and in vivo bioimaging probes. However, due to their ultra-low extinction coefficients as well as photobleaching problems, conventional molecular probes limit its practical utility. To address the above mentioned challenges, metal nanoclusters (MNCs) can serve as an excellent alternative with many unique features such as higher molar extinction coefficients/light absorbing capabilities, good photostability and appreciable fluorescence quantum yields. Herein, we reported a green synthesis of water soluble palladium nanoclusters (Pd NCs) and characterized them by using various spectroscopic and microscopic characterization techniques. These nanoclusters showed excellent photophysical properties with the characteristic emission peak centered at 500 nm under 420 nm photoexcitation wavelength. In vitro cytotoxicity studies in human cervical cancer cells (HeLa) cells reveal that Pd NCs exhibited good biocompatibility with an IC50 value of >100 µg/mL and also showed excellent co-localization and distribution throughout the cytoplasm region with a significant fraction translocating into cell nucleus. We foresee that Pd NCs will carry huge potential to serve as a new generation bioimaging nanoprobe owing to its smaller size, minimal cytotoxicity, nucleus translocation capability and good cell labelling properties.

Facile synthesis of water-soluble and biocompatible fluorescent nitrogen-doped carbon dots for cell imaging

The Analyst ◽  
2014 ◽  
Vol 139 (7) ◽  
pp. 1692-1696 ◽  
Author(s):  
Weiping Wang ◽  
Ya-Chun Lu ◽  
Hong Huang ◽  
Jiu-Ju Feng ◽  
Jian-Rong Chen ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Cell Imaging ◽  
Water Soluble ◽  
Soluble Nitrogen ◽  
Facile Synthesis ◽  
Nitrogen Doped ◽  
Low Toxicity ◽  
Good Biocompatibility ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon

A simple and green hydrothermal method was developed for preparation of water-soluble nitrogen-doped carbon dots (N-CDs) from streptomycin. The prepared N-CDs reveal low toxicity, high stability and good biocompatibility, which can be used as fluorescent probes for cell imaging.

Poly(amidoamine) dendrimer-supported organoplatinum antitumour agents

2009 ◽  
Vol 466 (2117) ◽  
pp. 1515-1526 ◽  
Author(s):  
B. A. Howell ◽  
D. Fan
Keyword(s):  
Water Solubility ◽  
High Surface ◽  
Pamam Dendrimer ◽  
Water Soluble ◽  
Antitumour Agents ◽  
Surface Functionality ◽  
Drug Conjugates ◽  
Carboxylate Groups ◽  
Polymeric Prodrug ◽  
Low Toxicity

While numerous water-soluble biocompatible polymers have been utilized for the construction of drug conjugates that offer significant advantages for drug delivery, poly(amidoamine) (PAMAM) dendrimers are superior in many ways for this purpose. They display nanoscale size, uniform shape, excellent water solubility, low toxicity and high surface functionality. In an attempt to circumvent the toxic side effects associated with the administration of organoplatinum drugs, a polymeric prodrug has been prepared from the treatment of a generation 4.5 PAMAM dendrimer with diaquo(1,2-diaminocyclohexane)platinum(II). A well-defined dendrimer–platinum conjugate containing 40 (1,2-diaminocyclohexane)platinum(II) units coordinated to the dendrimer surface via carboxylate groups is formed. This adduct is well behaved, water soluble, contains a high loading of platinum moieties and displays sustained release of active platinum species over a 24 h period under physiological conditions.

scholarly journals THE FORMATION OF HYDROGELS BASED ON CHITOSAN AND ITS WATER-SOLUBLE DERIVATIVES

2020 ◽  
Vol XXV ◽  
pp. 5-15
Keyword(s):  
Noncovalent Interactions ◽  
Water Soluble ◽  
Production Costs ◽  
Medical Applications ◽  
Covalent Bonds ◽  
Chitosan Derivatives ◽  
Ph Values ◽  
Extended Range ◽  
Low Toxicity ◽  
Physically Crosslinked

This review considers articles on the formation of hydrogels based on chitosan as well as succinylated and quaternized chitosan derivatives. They are synthesized using low toxicity reagents, under ordinary conditions (low production costs). Chitosan derivatives are soluble in an extended range of pH values and characterized by mucoadhesiveness, bioavailability and biodegradability, which extends the potential of their medical applications. One of the most important properties of chitosan and its derivatives is the ability to form hydrogels. Depending on the nature of the bonds that occur during formation, hydrogels are divided into chemically or physically crosslinked, or a mixture of the two. Chemically crosslinked gels have covalent bonds, while physically crosslinked gels are formed by noncovalent interactions, for example, ionic. Mixed hydrogels have both types of crosslinking.

scholarly journals Synthesis of a New Water-Soluble Melatonin Derivative with Low Toxicity and a Strong Effect on Sleep Aid

ACS Omega ◽  
2020 ◽  
Vol 5 (12) ◽  
pp. 6494-6499 ◽  
Author(s):  
Jianghong Zhang ◽  
Xu Yan ◽  
Yunpeng Tian ◽  
Wanyun Li ◽  
Haiyang Wang ◽  
...  
Keyword(s):  
Water Soluble ◽  
Low Toxicity

scholarly journals Synthesis of a New Potential Conjugated TAT-Peptide-Chitosan Nanoparticles Carrier via Disulphide Linkage

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Haliza Katas ◽  
Nik Nur Shamiha Nik Dzulkefli ◽  
Shariza Sahudin
Keyword(s):  
Plasmid Dna ◽  
Size Range ◽  
Chitosan Nanoparticles ◽  
Tat Peptide ◽  
Raman Spectrometry ◽  
Spectrometry Analysis ◽  
Dna Oligonucleotides ◽  
Cytotoxicity Studies ◽  
Low Toxicity

Chitosan and TAT peptide have been widely investigated as delivery systems for various biomolecules such as plasmid DNA, oligonucleotides, and siRNAs. Conjugation of chitosan with TAT-peptide was therefore expected to produce a carrier with enhanced ability to facilitate cellular uptake. In this study, chitosan nanoparticles (CNs) were prepared by ionic gelation method prior to conjugation with TAT-peptide via disulphide linkage (CN-TAT). The conjugation was performed at various TAT-peptide-to-chitosan weight ratios ranging from 0.008 : 1 to 0.125 : 1. siRNA as a model biomolecule was loaded by adsorption onto the CN-TAT. Nanosize range particles were produced with a size range of less than 700 nm depending on TAT-peptide concentration used. HPLC and Raman spectrometry analysis revealed that TAT-peptide was successfully conjugated to the CN via disulphide linkage. siRNA loading efficiency for CN-TAT was 93%  ±0.01.In vitrocytotoxicity studies showed that CN-TAT has relatively low toxicity. In conclusion, TAT conjugated onto CN via disulphide linkage was successfully synthesized, and its low cytoxicity demonstrates a potential for its use as a vector for biomolecules.

scholarly journals Modulating the Chemical and Biological Properties of Cancer Stem Cell-Potent Copper(II)-Nonsteroidal Anti-Inflammatory Drug Complexes

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1677 ◽  
Author(s):  
Shin ◽  
Eskandari ◽  
Suntharalingam
Keyword(s):  
Three Dimensional ◽  
Biological Properties ◽  
Culture Studies ◽  
Apoptosis Pathway ◽  
Cytotoxicity Studies ◽  
Ic50 Value ◽  
Low Toxicity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Micromolar Range

Copper(II) complexes bearing nonsteroidal anti-inflammatory drugs (NSAIDs) are known to potently kill cancer stem cells (CSCs), a subpopulation of tumour cells with high metastatic and relapse fidelity. One of the major disadvantages associated to these copper(II) complexes is their instability in the presence of strong cellular reductants (such as ascorbic acid). Here we present a biologically stable copper(II)-NSAID complex containing a bathocuproinedisulfonic acid disodium ligand and two indomethacin moieties, Cu(bathocuproinedisulfonic acid disodium)(indomethacin)2, 2. The copper(II) complex, 2 kills bulk breast cancer cells and breast CSC equally (in the sub-micromolar range) and displays very low toxicity against non-tumorigenic breast and kidney cells (IC50 value > 100 µM). Three-dimensional cell culture studies show that 2 can significantly reduce the number and size of breast CSC mammospheres formed (from single suspensions) to a similar level as salinomycin (an established anti-breast CSC agent). The copper(II) complex, 2 is taken up reasonably by breast CSCs and localises largely in the cytoplasm (>90%). Cytotoxicity studies in the presence of specific inhibitors suggest that 2 induces CSC death via a reactive oxygen species (ROS) and cyclooxygenase isoenzyme-2 (COX-2) dependent apoptosis pathway.

scholarly journals Organometallic carbonyl clusters: a new class of contrast agents for photoacoustic cerebral vascular imaging

2014 ◽  
Vol 50 (20) ◽  
pp. 2601-2603 ◽  
Author(s):  
Kien Voon Kong ◽  
Lun-De Liao ◽  
Zhiyong Lam ◽  
Nitish V. Thakor ◽  
Weng Kee Leong ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
High Stability ◽  
Photoacoustic Signal ◽  
Water Soluble ◽  
Vascular Imaging ◽  
Cerebral Vasculature ◽  
New Class ◽  
Excellent Candidate ◽  
Low Toxicity ◽  
Osmium Carbonyl

The strong photoacoustic signal of a water soluble osmium carbonyl cluster allowed it to be employed as a contrast agent to image the cerebral vasculature of a rat. The high stability and low toxicity of such a compound make it an excellent candidate in such biomedical applications.

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