scholarly journals Synthesis of a New Water-Soluble Melatonin Derivative with Low Toxicity and a Strong Effect on Sleep Aid

ACS Omega ◽  
2020 ◽  
Vol 5 (12) ◽  
pp. 6494-6499 ◽  
Author(s):  
Jianghong Zhang ◽  
Xu Yan ◽  
Yunpeng Tian ◽  
Wanyun Li ◽  
Haiyang Wang ◽  
...  
Keyword(s):  
Water Soluble ◽  
Low Toxicity

Facile synthesis of water-soluble and biocompatible fluorescent nitrogen-doped carbon dots for cell imaging

The Analyst ◽  
2014 ◽  
Vol 139 (7) ◽  
pp. 1692-1696 ◽  
Author(s):  
Weiping Wang ◽  
Ya-Chun Lu ◽  
Hong Huang ◽  
Jiu-Ju Feng ◽  
Jian-Rong Chen ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Cell Imaging ◽  
Water Soluble ◽  
Soluble Nitrogen ◽  
Facile Synthesis ◽  
Nitrogen Doped ◽  
Low Toxicity ◽  
Good Biocompatibility ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon

A simple and green hydrothermal method was developed for preparation of water-soluble nitrogen-doped carbon dots (N-CDs) from streptomycin. The prepared N-CDs reveal low toxicity, high stability and good biocompatibility, which can be used as fluorescent probes for cell imaging.

Poly(amidoamine) dendrimer-supported organoplatinum antitumour agents

2009 ◽  
Vol 466 (2117) ◽  
pp. 1515-1526 ◽  
Author(s):  
B. A. Howell ◽  
D. Fan
Keyword(s):  
Water Solubility ◽  
High Surface ◽  
Pamam Dendrimer ◽  
Water Soluble ◽  
Antitumour Agents ◽  
Surface Functionality ◽  
Drug Conjugates ◽  
Carboxylate Groups ◽  
Polymeric Prodrug ◽  
Low Toxicity

While numerous water-soluble biocompatible polymers have been utilized for the construction of drug conjugates that offer significant advantages for drug delivery, poly(amidoamine) (PAMAM) dendrimers are superior in many ways for this purpose. They display nanoscale size, uniform shape, excellent water solubility, low toxicity and high surface functionality. In an attempt to circumvent the toxic side effects associated with the administration of organoplatinum drugs, a polymeric prodrug has been prepared from the treatment of a generation 4.5 PAMAM dendrimer with diaquo(1,2-diaminocyclohexane)platinum(II). A well-defined dendrimer–platinum conjugate containing 40 (1,2-diaminocyclohexane)platinum(II) units coordinated to the dendrimer surface via carboxylate groups is formed. This adduct is well behaved, water soluble, contains a high loading of platinum moieties and displays sustained release of active platinum species over a 24 h period under physiological conditions.

scholarly journals THE FORMATION OF HYDROGELS BASED ON CHITOSAN AND ITS WATER-SOLUBLE DERIVATIVES

2020 ◽  
Vol XXV ◽  
pp. 5-15
Keyword(s):  
Noncovalent Interactions ◽  
Water Soluble ◽  
Production Costs ◽  
Medical Applications ◽  
Covalent Bonds ◽  
Chitosan Derivatives ◽  
Ph Values ◽  
Extended Range ◽  
Low Toxicity ◽  
Physically Crosslinked

This review considers articles on the formation of hydrogels based on chitosan as well as succinylated and quaternized chitosan derivatives. They are synthesized using low toxicity reagents, under ordinary conditions (low production costs). Chitosan derivatives are soluble in an extended range of pH values and characterized by mucoadhesiveness, bioavailability and biodegradability, which extends the potential of their medical applications. One of the most important properties of chitosan and its derivatives is the ability to form hydrogels. Depending on the nature of the bonds that occur during formation, hydrogels are divided into chemically or physically crosslinked, or a mixture of the two. Chemically crosslinked gels have covalent bonds, while physically crosslinked gels are formed by noncovalent interactions, for example, ionic. Mixed hydrogels have both types of crosslinking.

Synthesis, structural characterisation, and cytotoxicity studies of Bi, W, and Mo containing homo- and hetero-bimetallic polyoxometalates

2019 ◽  
Vol 48 (42) ◽  
pp. 15962-15969 ◽  
Author(s):  
Dimuthu C. Senevirathna ◽  
Melissa V. Werrett ◽  
Manja Kubeil ◽  
Holger Stephan ◽  
Philip C. Andrews
Keyword(s):  
Water Soluble ◽  
Embryonic Cells ◽  
Human Carcinoma ◽  
Structural Characterisation ◽  
Cytotoxicity Studies ◽  
Low Toxicity

High nuclearity, water soluble polyoxometalates composed of high Z number metals W, Mo and Bi demonstrate low toxicity to human carcinoma and healthy embryonic cells and their potential as radiosensitisers.

scholarly journals Organometallic carbonyl clusters: a new class of contrast agents for photoacoustic cerebral vascular imaging

2014 ◽  
Vol 50 (20) ◽  
pp. 2601-2603 ◽  
Author(s):  
Kien Voon Kong ◽  
Lun-De Liao ◽  
Zhiyong Lam ◽  
Nitish V. Thakor ◽  
Weng Kee Leong ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
High Stability ◽  
Photoacoustic Signal ◽  
Water Soluble ◽  
Vascular Imaging ◽  
Cerebral Vasculature ◽  
New Class ◽  
Excellent Candidate ◽  
Low Toxicity ◽  
Osmium Carbonyl

The strong photoacoustic signal of a water soluble osmium carbonyl cluster allowed it to be employed as a contrast agent to image the cerebral vasculature of a rat. The high stability and low toxicity of such a compound make it an excellent candidate in such biomedical applications.

An asymmetric binuclear zinc(ii) complex with mixed iminodiacetate and phenanthroline ligands: synthesis, characterization, structural conversion and anticancer properties

2016 ◽  
Vol 3 (7) ◽  
pp. 959-968 ◽  
Author(s):  
Lubin Ni ◽  
Juan Wang ◽  
Chang Liu ◽  
Jinhong Fan ◽  
Yun Sun ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Chemotherapeutic Agent ◽  
Water Soluble ◽  
Structural Conversion ◽  
Anticancer Properties ◽  
Low Toxicity ◽  
Phenanthroline Ligands

A water-soluble asymmetric binuclear zinc(ii) complex with mixed iminodiacetate and 1,10-phenanthroline ligands exhibited promising anticancer activity and low toxicity, suggesting potential as a chemotherapeutic agent.

Bi[5,5-bis(hydroxymethyl)-3-methyl-2-oxomorpholin-3-yl] (BHM-3 dimer). A low toxicity, water-soluble, one-electron reducing agent

1993 ◽  
Vol 58 (26) ◽  
pp. 7355-7363 ◽  
Author(s):  
Giorgio Gaudiano ◽  
Elizabeth Frank ◽  
Michael S. Wysor ◽  
Steven D. Averbuch ◽  
Tad H. Koch
Keyword(s):  
Reducing Agent ◽  
Water Soluble ◽  
Low Toxicity

scholarly journals Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots

2021 ◽  
Vol 22 (22) ◽  
pp. 12514
Author(s):  
Vuyelwa Ncapayi ◽  
Neethu Ninan ◽  
Thabang C. Lebepe ◽  
Sundararajan Parani ◽  
Aswathy Ravindran Girija ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Quantum Dots ◽  
Cancer Cells ◽  
Near Infrared ◽  
Particle Diameter ◽  
Spherical Shape ◽  
Water Soluble ◽  
Prostate Cancer Cells ◽  
Intracellular Targeting ◽  
Low Toxicity

The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in Staphylococcus aureus, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.

TYPES OF CHITOZAN MODIFICATION BY USING VARIOUS DERIVATIVE AGENTS

2021 ◽  
pp. 23-30
Author(s):  
Pyatigorskaya N.V. ◽  
Kargin V.S. ◽  
Brkich G.E.
Keyword(s):  
Biological Properties ◽  
Water Soluble ◽  
Patent Data ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Modified Chitosan ◽  
The Matrix ◽  
Low Toxicity ◽  
Dissolved Form ◽  
Salt Forms

The prevalence of the study of chitosan is associated with favorable biological properties of the polymer: low toxicity, biodegradability, and biocompatibility with cells of the human body. Chitosan is a complex aminopolysaccharide consisting of two types of monosaccharaides: 2-acetamide-D-glucose and 2-amino-D-glucose connected by a 1,4-β-glycosidic bond, obtained by chitosan by chitin deacetylation. Chitosan has hemostatic, hypolipedymic and antimicrobial activity against gram-positive and gram-negative microorganisms. However, the preparation of various drugs based on it is accompanied by difficulties in the development of biodegradable compositions that are related to the field of application. For the immobilization of various compounds used as drugs for the treatment of complications associated with damage to the skin, it is possible to use chitosan in dissolved form, converted into a salt form. However, salt forms of chitosan are water-soluble polymers, which leads to the rapid degradation of the matrix and the release of the drug from it, due to hydrophilicity. Additional lipophilization is required to obtain insoluble chitosan structures. Therefore, various modified chitosan structures are used that have suitable properties for the manufacture of a medicament. In addition, lipophilization of the chitosan structure allows the immobilization of more lipophilic structures. The purpose of this work was to study the literature and patent data sources for conducting information-analytical search of the approach. That led to the choice of a modified chitosan structure for its use in the pharmaceutical development of finished dosage forms. The article considers various types of derivatizing agents and the properties of modified chitosan structures.

A water-soluble aminated β1-3D-glucan derivative causes regression of solid tumors in mice

1986 ◽  
Vol 6 (9) ◽  
pp. 845-851 ◽  
Author(s):  
Rolf Seljelid
Keyword(s):  
Tumor Growth ◽  
Solid Tumors ◽  
Biological Fluids ◽  
Tumor Therapy ◽  
Water Soluble ◽  
Complete Regression ◽  
Apparent Effect ◽  
Promising Tool ◽  
Low Toxicity ◽  
Meth A Sarcoma

Meth A sarcoma, when inoculated in the skin, grew progressively in hybrid CB6 Fl(Balb/c×C57B1/6) mice. When water-soluble aminated β1-3D-glucan (AG) was injected intravenously or intraperitoneally on day 7 of tumor growth, the tumors underwent complete regression. When the injection was performed on day 3 there was regression of tumors in only about half of the cases. When the injection was performed on day 14 there was no apparent effect on tumor growth. Tumors in thymectonized animals did not appear to respond to treatment with AG on day 7. The relatively simple chemistry and low toxicity of AG, together with its solubility in biological fluids, makes it a promising tool in experimental—and possibly clinical—tumor therapy.

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