The synthesis and bioimaging of a biocompatible hydrogen sulfide fluorescent probe with high sensitivity and selectivity

The Analyst ◽  
2020 ◽  
Vol 145 (6) ◽  
pp. 2305-2310 ◽  
Author(s):  
Ruqiao Zhou ◽  
Guiling Cui ◽  
Qingrong Qi ◽  
Wencai Huang ◽  
Li Yang
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probe ◽  
High Sensitivity ◽  
The Past ◽  
Sensitivity And Selectivity ◽  
Poisonous Gas

Hydrogen sulfide (H2S), a well-known poisonous gas, has been recognized as a critical endogenous gas transmitter in the past decade.

A novel FRET-based fluorescent probe for the selective detection of hydrogen sulfide (H2S) and its application for bioimaging

2018 ◽  
Vol 6 (30) ◽  
pp. 4903-4908 ◽  
Author(s):  
Qi Zhao ◽  
Fangjun Huo ◽  
Jin Kang ◽  
Yongbin Zhang ◽  
Caixia Yin
Keyword(s):  
Hydrogen Sulfide ◽  
Detection Limit ◽  
Fluorescent Probe ◽  
Nude Mice ◽  
High Sensitivity ◽  
Fast Response ◽  
Living Cells ◽  
Selective Detection ◽  
Low Detection Limit ◽  
Sensitivity And Selectivity

Herein, our group developed a fast response fluorescent probe (Flu-N3) for H2S on the basis of the 7-amino-4-methylcoumarin and fluorescein FRET system with high sensitivity and selectivity and a low detection limit of 0.031 μM. Moreover, the probe was successfully applied to image exogenous and endogenous H2S in living cells and nude mice.

A colorimetric and near-infrared fluorescent probe with high sensitivity and selectivity for acid phosphatase and inhibitor screening

2014 ◽  
Vol 50 (63) ◽  
pp. 8677 ◽  
Author(s):  
Yongqian Xu ◽  
Benhao Li ◽  
Liangliang Xiao ◽  
Jia Ouyang ◽  
Shiguo Sun ◽  
...  
Keyword(s):  
Acid Phosphatase ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
High Sensitivity ◽  
Inhibitor Screening ◽  
Sensitivity And Selectivity

A dual-emitting Tb(iii)&Yb(iii)-functionalized coordination polymer: a “turn-on” sensor for N-methylformamide in urine and a “turn-off” sensor for methylglyoxal in serum

2019 ◽  
Vol 48 (38) ◽  
pp. 14408-14417 ◽  
Author(s):  
Xubin Zheng ◽  
Ruiqing Fan ◽  
Haoyang Lu ◽  
Bowen Wang ◽  
Jingkun Wu ◽  
...  
Keyword(s):  
Coordination Polymer ◽  
Fluorescent Probe ◽  
High Sensitivity ◽  
Turn On ◽  
Postsynthetic Modification ◽  
Sensitivity And Selectivity

A fluorescent probe designed and prepared through postsynthetic modification (PSM) showed high sensitivity and selectivity for N-methylformamide (NMF) in urine and methylglyoxal (MGO) in serum.

scholarly journals Cancer-Specific Biomarker hNQO1-Activatable Fluorescent Probe for Imaging Cancer Cells In Vitro and In Vivo

Cancers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 470 ◽  
Author(s):  
Surendra Punganuru ◽  
Hanumantha Madala ◽  
Viswanath Arutla ◽  
Kalkunte Srivenugopal
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Stokes Shift ◽  
High Sensitivity ◽  
Cell Permeability ◽  
Quinone Oxidoreductase ◽  
Brain Tumor Cells ◽  
Sensitivity And Selectivity

Human NAD(P)H quinone oxidoreductase-1 (hNQO1) is an important cancer-related biomarker, which shows significant overexpression in malignant cells. Developing an effective method for detecting NQO1 activity with high sensitivity and selectivity in tumors holds a great potential for cancer diagnosis, treatment, and management. In the present study, we report a new dicyanoisophorone (DCP) based fluorescent probe (NQ-DCP) capable of monitoring hNQO1 activity in vitro and in vivo in both ratiometric and turn-on model. NQ-DCP was prepared by conjugating dicyanoisophorone fluoroprobe with hNQO1 activatable quinone propionic acid (QPA), which remain non-fluorescent until activation by tumor-specific hNQO1. NQ-DCP featured a large Stokes shift (145 nm), excellent biocompatibility, cell permeability, and selectivity towards hNQO1 allowed to differentiate cancer cells from healthy cells. We have successfully employed NQ-DCP to monitor non-invasive endogenous hNQO1 activity in brain tumor cells in vitro and in xenografted tumors developed in nude mice.

scholarly journals A highly selective and sensitive fluorescent probe for lactate dehydrogenase based on ultrabright adenosine monophosphate capped gold nanoclusters

RSC Advances ◽  
2017 ◽  
Vol 7 (22) ◽  
pp. 13438-13443 ◽  
Author(s):  
Jiao Liu ◽  
Hong-Wei Li ◽  
Yuqing Wu
Keyword(s):  
Lactate Dehydrogenase ◽  
Detection Limit ◽  
Fluorescent Probe ◽  
Fluorescence Probe ◽  
Gold Nanoclusters ◽  
High Sensitivity ◽  
Adenosine Monophosphate ◽  
Low Detection Limit ◽  
Sensitivity And Selectivity

The ultrabright AuNCs@AMP are used as fluorescence probe to detect lactate dehydrogenase (LDH) with high sensitivity and selectivity, showing an extremely low detection limit of 0.2 nM (26 pg μL−1, 0.8 U L−1).

A selective and sensitive phthalimide-based fluorescent probe for hydrogen sulfide with a large Stokes shift

RSC Advances ◽  
2015 ◽  
Vol 5 (119) ◽  
pp. 98154-98159 ◽  
Author(s):  
Liu Yang ◽  
Xingjiang Liu ◽  
Li Gao ◽  
Fengpei Qi ◽  
Huihui Tian ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probe ◽  
Stokes Shift ◽  
High Sensitivity ◽  
Living Cells ◽  
Large Stokes Shift

A phthalimide-based fluorescent probe for H2S with a large Stokes shift has been developed. This probe displayed good selectivity and high sensitivity. Imaging intracellular H2S by using this probe was successfully achieved in living cells.

Pyrene appended thymine derivative for selective turn-on fluorescence sensing of uric acid in live cells

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 66774-66778 ◽  
Author(s):  
Prithidipa Sahoo ◽  
Himadri Sekhar Sarkar ◽  
Sujoy Das ◽  
Kalipada Maiti ◽  
Md Raihan Uddin ◽  
...  
Keyword(s):  
Uric Acid ◽  
Fluorescent Probe ◽  
High Sensitivity ◽  
Living Cells ◽  
Live Cells ◽  
Fluorescence Sensing ◽  
Turn On ◽  
Sensitivity And Selectivity ◽  
First Time

A new ‘turn-ON’ fluorescent probe, pyrene appended thymine acetamide (PTA), with high sensitivity and selectivity for the detection of uric acid (UA) was developed and first time imaging of uric acid in living cells in water was achieved.

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