scholarly journals Development of tungsten bronze nanorods for redox-enhanced photoacoustic imaging-guided photothermal therapy of tumors

RSC Advances ◽  
2018 ◽  
Vol 8 (47) ◽  
pp. 26713-26719 ◽  
Author(s):  
Hongbo Gao ◽  
Xiangming Fang ◽  
Jing Xiang ◽  
Xiaohang Liu ◽  
JianPing Zhang ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Tungsten Bronze ◽  
Redox Status

Although various kinds of nanomaterials have been used as anticancer theranostics by exploiting the tumor microenvironment, relatively few nanomaterials can be efficiently activated by the tumor redox status for imaging and therapy.

Tumor microenvironment-activated NIR-II reagents for tumor imaging and therapy

2020 ◽  
Vol 8 (22) ◽  
pp. 4738-4747 ◽  
Author(s):  
Xue Zhang ◽  
Lu An ◽  
Qiwei Tian ◽  
Jiaomin Lin ◽  
Shiping Yang
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Tumor Imaging ◽  
Photoacoustic Imaging ◽  
Tumor Diagnosis ◽  
Diagnosis And Treatment ◽  
Recent Advances

This review summarizes the recent advances of tumor microenvironment-activated NIR-II agents for tumor diagnosis and treatment, including smart NIR-II fluorescence imaging, photoacoustic imaging, photothermal therapy and photodynamic therapy.

scholarly journals A tumor microenvironment–induced absorption red-shifted polymer nanoparticle for simultaneously activated photoacoustic imaging and photothermal therapy

2021 ◽  
Vol 7 (12) ◽  
pp. eabe3588
Author(s):  
Shulong Wang ◽  
Liangliang Zhang ◽  
Jingjin Zhao ◽  
Min He ◽  
Yong Huang ◽  
...  
Keyword(s):  
Absorption Spectrum ◽  
Tumor Microenvironment ◽  
Redox Reaction ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Photoacoustic Imaging ◽  
Diagnosis And Treatment ◽  
Induced Absorption

Tumor microenvironment–responsive therapy has enormous application potential in the diagnosis and treatment of cancer. The glutathione (GSH) level has been shown to be significantly increased in tumor tissues. Thus, GSH can be used as an effective endogenous molecule for diagnosis and tumor microenvironment–activated therapy. In this study, we prepared a tumor microenvironment–induced, absorption spectrum red-shifted, iron-copper co-doped polyaniline nanoparticle (Fe-Cu@PANI). The Cu(II) in this nanoparticle can undergo a redox reaction with GSH in tumors. The redox reaction induces a red shift in the absorption spectrum of the Fe-Cu@PANI nanoparticles from the visible to the near-infrared region accompanying with the etching of this nanoparticle, which simultaneously activates tumor photoacoustic imaging and photothermal therapy, thereby improving the accuracy of in vivo tumor imaging and the efficiency of photothermal therapy. The nanoparticle prepared in this study has broad application prospects in the diagnosis and treatment of cancer.

scholarly journals Tumor microenvironment-triggered fabrication of gold nanomachines for tumor-specific photoacoustic imaging and photothermal therapy

2017 ◽  
Vol 8 (7) ◽  
pp. 4896-4903 ◽  
Author(s):  
Zhengze Yu ◽  
Meimei Wang ◽  
Wei Pan ◽  
Hongyu Wang ◽  
Na Li ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Diagnosis And Therapy ◽  
Theranostic Agent ◽  
Tumor Selective ◽  
Dna Nanomachine

An alpha-cyclodextrin (α-CD)-based gold/DNA nanomachine was developed as a novel theranostic agent for tumor-selective diagnosis and therapy.

Pyrazino[2,3-g]quinoxaline-Based Nanoparticles as Near-Infrared Phototheranostic Agents for Efficient Photoacoustic-Imaging-Guided Photothermal Therapy

2021 ◽  
Vol 4 (2) ◽  
pp. 2019-2029
Author(s):  
Li-Peng Zhang ◽  
Lin Kang ◽  
Xianqiang Li ◽  
Shiyang Liu ◽  
Tianlong Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging

Core-Shell Pd@Au Nanoplates as Theranostic Agents for In-Vivo Photoacoustic Imaging, CT Imaging, and Photothermal Therapy

2014 ◽  
Vol 26 (48) ◽  
pp. 8210-8216 ◽  
Author(s):  
Mei Chen ◽  
Shaoheng Tang ◽  
Zhide Guo ◽  
Xiaoyong Wang ◽  
Shiguang Mo ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Ct Imaging ◽  
Core Shell ◽  
Theranostic Agents

Organic Semiconducting Macromolecular Dyes for NIR‐II Photoacoustic Imaging and Photothermal Therapy

2021 ◽  
pp. 2104650
Author(s):  
Chao Yin ◽  
Xiaozhen Li ◽  
Yi Wang ◽  
Yuying Liang ◽  
Shan Zhou ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Photoacoustic Imaging

How do bismuth-based nanomaterials function as promising theranostic agents for the tumor diagnosis and therapy?

2021 ◽  
Vol 28 ◽  
Author(s):  
Mengkui Ding ◽  
Jinyao Liu ◽  
Junlei Yang ◽  
Hui Wang ◽  
Xianjin Xie ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Photoacoustic Imaging ◽  
Computed Tomography Imaging ◽  
X Ray ◽  
Synergistic Enhancement ◽  
Tumour Location ◽  
X Ray Computed ◽  
Low Toxicity ◽  
Theranostic Agents ◽  
Multi Mode

: The complexity of tumor microenvironment and the diversity of tumors seriously affect the therapeutic effect, the focus, therefore, has gradually been shifted from monotherapy to combination therapy in clinical research in order to improve the curative effect. The synergistic enhancement interactions among multiple monotherapies majorly contribute to the birth of the multi-mode cooperative therapy, whose effect of the treatment is clearly stronger than that of any single therapy. In addition, the accurate diagnosis of the tumour location is also crucial to the treatment. Bismuth-based nanomaterials (NMs) hold great properties as promising theranostic platforms based on their many unique features that include low toxicity, excellent photothermal conversion efficiency as well as high ability of X-ray computed tomography imaging and photoacoustic imaging. In this review, we will introduce briefly the main features of tumor microenvironment first and its effect on the mechanism of nanomedicine actions and present the recent advances of bismuth-based NMs for diagnosis and photothermal therapy-based combined therapies using bismuth-based NMs are presented, which may provide a new way for overcoming drug resistance and hypoxia. At the end, further challenges and outlooks regarding this promising field are discussed accompanied with some design tips for bismuth-based NMs, hoping to provide researchers some inspirations to design safe and effective nanotherapeutic agents for the clinical treatments of cancers.

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