Pyrazino[2,3-g]quinoxaline-Based Nanoparticles as Near-Infrared Phototheranostic Agents for Efficient Photoacoustic-Imaging-Guided Photothermal Therapy

2021 ◽  
Vol 4 (2) ◽  
pp. 2019-2029
Author(s):  
Li-Peng Zhang ◽  
Lin Kang ◽  
Xianqiang Li ◽  
Shiyang Liu ◽  
Tianlong Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging

scholarly journals Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer

2020 ◽  
Vol 6 (33) ◽  
pp. eaba3546 ◽  
Author(s):  
Xuan Yi ◽  
Hailin Zhou ◽  
Yu Chao ◽  
Saisai Xiong ◽  
Jing Zhong ◽  
...  
Keyword(s):  
Immune Responses ◽  
Photothermal Therapy ◽  
Tumor Metastasis ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Immune Checkpoint Blockade ◽  
Immune Memory ◽  
Immunotherapy Of Cancer ◽  
Rapid Clearance ◽  
Inhibit Tumor Metastasis

We discovered that attenuated Salmonella after intravenous injection would proliferate within various types of solid tumors but show rapid clearance in normal organs, without rendering notable toxicity. Bacteria-induced inflammation would trigger thrombosis in the infected tumors by destroying tumor blood vessels. Six types of tested tumors would all turn into darkened color with strong near-infrared absorbance, as observed by photoacoustic imaging. Under laser irradiation, those bacterial-infected tumors would be effectively ablated. Because of the immune-stimulation function, such bacteria-based photothermal therapy (PTT) would subsequently trigger antitumor immune responses, which could be further enhanced by immune checkpoint blockade to effectively suppress the growth of abscopal tumors. A robust immune memory effect to reject rechallenged tumors is also observed after bacteria-based PTT. Our work demonstrates that bacteria by themselves could act as a tumor-specific PTT agent to enable photoimmunotherapy cancer therapy to inhibit tumor metastasis and recurrence.

Metallic 1T Phase Enabling MoS 2 Nanodots as an Efficient Agent for Photoacoustic Imaging Guided Photothermal Therapy in the Near‐Infrared‐II Window

Small ◽  
2020 ◽  
Vol 16 (43) ◽  
pp. 2004173 ◽  
Author(s):  
Zhan Zhou ◽  
Bowen Li ◽  
Chuang Shen ◽  
Di Wu ◽  
Huacheng Fan ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging

Theranostics of Gold Nanoparticles with an Emphasis on Photoacoustic Imaging and Photothermal Therapy

2018 ◽  
Vol 24 (23) ◽  
pp. 2719-2728 ◽  
Author(s):  
Yi Liu ◽  
Wenhui Ma ◽  
Jing Wang
Keyword(s):  
Gold Nanoparticles ◽  
Temperature Control ◽  
Photothermal Therapy ◽  
Recent Progress ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Diagnosis And Treatment ◽  
Chemical Characteristics ◽  
Nir Light ◽  
Physical And Chemical

Gold nanoparticles (AuNPs) are promising biomedical agents in terms of both imaging and therapy, exhibiting excellent physical and chemical characteristics. The actions of AuNPs can be remotely controlled using strong near-infrared (NIR) light, associated with minimal lateral invasion. Employing the photoacoustic (PA) principle, AuNPs integrate imaging and temperature control, affording both diagnosis and treatment mediated by NIR light. We here review recent progress in the theranostic field employing AuNPs to both PA and photothermal ends.

Near-infrared-II Light Excitation Thermosensitive Liposomes for Photoacoustic Imaging Guided and Enhanced Photothermal-Chemo Synergistic Tumor Therapy

2021 ◽  
Author(s):  
Yeneng Dai ◽  
Wenyu Du ◽  
Diya Gao ◽  
Haowei Zhu ◽  
Fan Zhang ◽  
...  
Keyword(s):  
Penetration Depth ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Tumor Therapy ◽  
Great Success ◽  
Light Excitation ◽  
Thermosensitive Liposomes

Although the great success of photothermal therapy (PTT), it still suffers from many obstacles, such as the limited penetration depth of light, thermoresistance of tumor, as well as the limitations...

scholarly journals Photoacoustic imaging and photothermal therapy in the second near-infrared window

2019 ◽  
Vol 43 (23) ◽  
pp. 8835-8851 ◽  
Author(s):  
Xiaoguang Ge ◽  
Qinrui Fu ◽  
Lin Bai ◽  
Bin Chen ◽  
Renjie Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Recent Progress ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Infrared Window

This review summarizes the recent progress of PA imaging and PTT agents in the second NIR window.

An injectable hybrid hydrogel based on a genetically engineered polypeptide for second near-infrared fluorescence/photoacoustic imaging-monitored sustained chemo-photothermal therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (34) ◽  
pp. 16080-16091 ◽  
Author(s):  
Ruimei Jin ◽  
Xiaoquan Yang ◽  
Donghui Zhao ◽  
Xiaolin Hou ◽  
Chaoqing Li ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Genetically Engineered ◽  
Hybrid Hydrogel ◽  
Near Infrared Fluorescence

An injectable multifunctional hydrogel based on an engineered polypeptide, Ag2S quantum dots, and paclitaxel has been developed for sustained chemo-photothermal therapy.

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