scholarly journals UHPLC-ESI-Q-TOF-MS/MS analysis, antioxidant activity combined fingerprints for quality consistency evaluation of compound liquorice tablets

RSC Advances ◽  
2018 ◽  
Vol 8 (49) ◽  
pp. 27661-27673 ◽  
Author(s):  
Yujing Zhang ◽  
Chao Wang ◽  
Fangliang Yang ◽  
Zhe Yang ◽  
Fangren Wang ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Herbal Medicines ◽  
Detection Technique ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Ms Analysis ◽  
Consistency Evaluation ◽  
Tof Ms

Traditional Chinese medicines (TCM)/herbal medicines (HM) are too complicated to comprehensively investigate their quality consistency effectively with a single detection technique.

Monitoring quality consistency of Ixeris sonchifolia (Bunge) Hance injection by integrating UV spectroscopic fingerprints, a multi-wavelength fusion fingerprint method, antioxidant activities and UHPLC/Q-TOF-MS

RSC Advances ◽  
2016 ◽  
Vol 6 (90) ◽  
pp. 87616-87627 ◽  
Author(s):  
Lanping Yang ◽  
Xiuman Xie ◽  
Liu Yang ◽  
Jing Zhang ◽  
Guoxiang Sun
Keyword(s):  
Antioxidant Activities ◽  
Herbal Medicines ◽  
Detection Technique ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Multi Wavelength ◽  
Ixeris Sonchifolia ◽  
Monitoring Quality ◽  
Tof Ms

Traditional Chinese medicines/herbal medicines (TCM/HM) are too complicated mixture systems to investigate their quality consistency effectively using a single detection technique.

scholarly journals Quality assessment and antioxidant activities of the blossoms of Inula nervosa Wall

2020 ◽  
Author(s):  
Li-xia Hu ◽  
Mei-feng Luo ◽  
Wen-jing Guo ◽  
Xiao He ◽  
Jun Zhou ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Quantitative Data ◽  
Antioxidant Activities ◽  
Quality Criteria ◽  
Chemical Compounds ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Chemical Profiling ◽  
Multiple Origins ◽  
The Difference

Abstract Background Currently, although Inula nervosa Wall is well investigated, little is understood about blossoms of Inula nervosa Wall (BINW). Objective In this work, we systematically investigated the antioxidant activity of the extract from BINW by various standard assays including DPPH free radical ability, ABTS• +, and FRAP. Methods Chemical compounds are tentatively identified through an UHPLC-QTOF-MS system. Furthermore, the contents of nine compounds were detected with UHPLC method coupled with PDA. By carefully analyzing the quantitative data via clusters analysis and PCA. Results 46 compounds are tentatively identified and our results showed that 9 compound samples in 21 batches of BINW collected from different areas could be differentiated and analyzed by a heatmap visualization. In addition, the contents of nine compounds (flavonoids, phenolic acids) exhibited a total of higher amounts and better antioxidant activities from Yunnan than those from other three origins. Conclusions Our study not only developed a powerful platform to explain the difference traditional Chinese medicines (TCMs) species that in closely related through the chemometric and chemical profiling, but also presented a useful method to establish quality criteria of BINW with multiple origins. Highlights To detailly characterize the BINW, we not only performed DPPH, FRAP and ABTS assays to investigate its antioxidant activity, but also established UHPLC-QTOF-MS/MS and UHPLC-PDA based methods to comprehensively identify and qualitatively analyze its components.

GC/MS analysis on anorectics adulterated in traditional chinese medicines

2020 ◽  
Vol 8 (4) ◽  
Author(s):  
M.-C. Tseng ◽  
M.-J. Tsai ◽  
J.-H. Lin ◽  
K.-C. Wen
Keyword(s):  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Ms Analysis

scholarly journals A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

2016 ◽  
Vol 2016 ◽  
pp. 1-31 ◽  
Author(s):  
Piyush Mehta ◽  
Vividha Dhapte
Keyword(s):  
Chemical Constituents ◽  
Herbal Medicines ◽  
Pharmacokinetic Profile ◽  
Pharmacokinetic Data ◽  
Therapeutic Effects ◽  
Traditional Chinese Medicines ◽  
Herbal Drug ◽  
Major Drawback ◽  
Chinese Medicines ◽  
Wide Range

Herbal medicines are the oldest and most widely used form of treatment for welfare of mankind. Herbal medicines possess strong reputation as complementary treatment across the globe due to their easy accessibility and safety. Particularly traditional Chinese medicines (TCM) are very popular due to their desirable therapeutic effects. They already have been proven for their remarkable potential in treatment of wide range of disease ailments. The major drawback in using herbal medicines is lack of standardisation aspects due to the complexity of chemical constituents. Pharmacokinetics study of such medicines helps forecast a range of events related to efficacy, safety, and toxicity profile of them. Apart from this, pharmacokinetics studies also recommended by various regulatory agencies during diverse stages of herbal drug development. Thus it is highly essential to have knowledge about the pharmacokinetic properties of any herbal drug. Thus it was thought that it will be worthwhile to compile the pharmacokinetic data of TCM which will be helpful for the researchers involved in further research on TCM. To portray entire picture about absorption, distribution, metabolism, and excretion (ADME) of some TCM, this well-designed scientific review covers the pharmacokinetic profile of 50 TCM available from 2003 and onwards.

scholarly journals PHYTOCHEMICAL PROFILING USING LC-Q-TOF-MS ANALYSIS AND IN VITRO ANTIOXIDANT ACTIVITY OF A RARE SALT-SECRETING MANGROVE AEGIALITIS ROTUNDIFOLIA ROXB. LEAVES EXTRACT

2019 ◽  
pp. 37-47
Author(s):  
Debjit Ghosh ◽  
Sumanta Mondal ◽  
Prof. Karipeddi Ramakrishna
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Reducing Power ◽  
In Vitro Models ◽  
Phytochemical Analysis ◽  
Ms Analysis ◽  
Aegialitis Rotundifolia ◽  
Tof Ms

Objective: The present work deals with the qualitative study of the phytoconstituents present in Aegialitis rotundifolia Roxb., ethanolic leaves extract and evaluate its antioxidant properties in vitro. Methods: The qualitative phytochemical analysis of the extract was performed first using preliminary phytochemical tests and then by liquid chromatography quadrupole-time-of-flight mass spectrometry (LC-Q-TOF-MS). The antioxidant properties were investigated comprehensively using seven in vitro models viz., 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, nitric oxide (NO) scavenging, hydrogen peroxide (H2O2) scavenging, superoxide (SOD) radical scavenging, lipid peroxidation (LPO) assay, reducing power (RP), and total antioxidant activity. Results: The preliminary phytochemical analysis revealed the presence of several important phytochemical groups whereas the LC-Q-TOF-MS analysis detected 25 phytoconstituents in the extract mostly belonging to flavonoids and alkaloids. The test extract showed strong dose-dependent antioxidant activity in all the seven in vitro models, however, the activity of the extracts was slightly lower compared to the reference standard ascorbic acid. Conclusion: The test extract showed strong antioxidant properties which could be possibly due to the phytoconstituents detected in the extract.

scholarly journals Evaluation of extraction methods for pharmacologically active compounds from anticonvulsant traditional Chinese medicines: Gou Teng, Tian Ma, Jiang Can using DART-TOF-MS

2021 ◽  
Vol 13 (7) ◽  
pp. 884-893
Author(s):  
Kimberly N. Karin ◽  
Justin L. Poklis ◽  
Michelle R. Peace
Keyword(s):  
Extraction Methods ◽  
Rapid Analysis ◽  
Traditional Chinese Medicines ◽  
Microwave Assisted Extraction ◽  
Chinese Medicines ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Pharmacologically Active ◽  
Pharmacologically Active Compounds ◽  
Tof Ms

With the popularity of natural products, rapid analysis of pharmacologically active analytes from natural matrices is critical for public health. Microwave-assisted extraction with DART-MS provides efficient analysis of analytes from herbal matrices.

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