Monitoring quality consistency of Ixeris sonchifolia (Bunge) Hance injection by integrating UV spectroscopic fingerprints, a multi-wavelength fusion fingerprint method, antioxidant activities and UHPLC/Q-TOF-MS

RSC Advances ◽  
2016 ◽  
Vol 6 (90) ◽  
pp. 87616-87627 ◽  
Author(s):  
Lanping Yang ◽  
Xiuman Xie ◽  
Liu Yang ◽  
Jing Zhang ◽  
Guoxiang Sun
Keyword(s):  
Antioxidant Activities ◽  
Herbal Medicines ◽  
Detection Technique ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Multi Wavelength ◽  
Ixeris Sonchifolia ◽  
Monitoring Quality ◽  
Tof Ms

Traditional Chinese medicines/herbal medicines (TCM/HM) are too complicated mixture systems to investigate their quality consistency effectively using a single detection technique.

scholarly journals UHPLC-ESI-Q-TOF-MS/MS analysis, antioxidant activity combined fingerprints for quality consistency evaluation of compound liquorice tablets

RSC Advances ◽  
2018 ◽  
Vol 8 (49) ◽  
pp. 27661-27673 ◽  
Author(s):  
Yujing Zhang ◽  
Chao Wang ◽  
Fangliang Yang ◽  
Zhe Yang ◽  
Fangren Wang ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Herbal Medicines ◽  
Detection Technique ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Ms Analysis ◽  
Consistency Evaluation ◽  
Tof Ms

Traditional Chinese medicines (TCM)/herbal medicines (HM) are too complicated to comprehensively investigate their quality consistency effectively with a single detection technique.

scholarly journals Quality assessment and antioxidant activities of the blossoms of Inula nervosa Wall

2020 ◽  
Author(s):  
Li-xia Hu ◽  
Mei-feng Luo ◽  
Wen-jing Guo ◽  
Xiao He ◽  
Jun Zhou ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Quantitative Data ◽  
Antioxidant Activities ◽  
Quality Criteria ◽  
Chemical Compounds ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Chemical Profiling ◽  
Multiple Origins ◽  
The Difference

Abstract Background Currently, although Inula nervosa Wall is well investigated, little is understood about blossoms of Inula nervosa Wall (BINW). Objective In this work, we systematically investigated the antioxidant activity of the extract from BINW by various standard assays including DPPH free radical ability, ABTS• +, and FRAP. Methods Chemical compounds are tentatively identified through an UHPLC-QTOF-MS system. Furthermore, the contents of nine compounds were detected with UHPLC method coupled with PDA. By carefully analyzing the quantitative data via clusters analysis and PCA. Results 46 compounds are tentatively identified and our results showed that 9 compound samples in 21 batches of BINW collected from different areas could be differentiated and analyzed by a heatmap visualization. In addition, the contents of nine compounds (flavonoids, phenolic acids) exhibited a total of higher amounts and better antioxidant activities from Yunnan than those from other three origins. Conclusions Our study not only developed a powerful platform to explain the difference traditional Chinese medicines (TCMs) species that in closely related through the chemometric and chemical profiling, but also presented a useful method to establish quality criteria of BINW with multiple origins. Highlights To detailly characterize the BINW, we not only performed DPPH, FRAP and ABTS assays to investigate its antioxidant activity, but also established UHPLC-QTOF-MS/MS and UHPLC-PDA based methods to comprehensively identify and qualitatively analyze its components.

scholarly journals The Study of Steaming Durations and Temperatures on the Chemical Characterization, Neuroprotective, and Antioxidant Activities of Panax notoginseng

2022 ◽  
Vol 2022 ◽  
pp. 1-13
Author(s):  
Didi Ma ◽  
Jue Wang ◽  
Guo Yin ◽  
Lijun Wang ◽  
Yibao Jin ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Chemical Characterization ◽  
Panax Notoginseng ◽  
Absorption Capacity ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Hplc Fingerprint ◽  
Relationship Analysis ◽  
Antioxidant Effects ◽  
Spectrum Effect

Panax notoginseng (PN) is one of the most valuable traditional Chinese medicines and has extensive pharmacological effects. Recent studies demonstrated that PN exhibited pharmacological effect related to Alzheimer’s disease (AD). However, whether steaming process can boost its anti-AD activity is still unexplored. To fill this gap, effects of steaming durations and temperatures on the chemical characterization, neuroprotective and antioxidant activities of PN were systematically investigated in this study. HPLC fingerprint coupled with quantitative analysis demonstrated striking conversion of original saponins to less polar ones with the increase in the steaming time and temperature. In the viewpoint of anti-AD activity on neuroprotective and antioxidant effects, several steamed PN samples (110°C-6/8/10 h, 120°C ‐4/6 h samples) displayed a significant increase both in cell viability and oxygen radical absorption capacity (ORAC) values compared with the no steamed one ( P < 0.01 or P < 0.005 ). Steaming temperature had the greater impact on the change of chemical composition and anti-AD activity of PN. Moreover, the spectrum-effect relationship analysis revealed that the transformed saponins were partially responsible for the increased neuroprotective and antioxidant effects of steamed PN. Therefore, steamed PN could be used as a potential crude drug for prevention and treatment of AD.

scholarly journals A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

2016 ◽  
Vol 2016 ◽  
pp. 1-31 ◽  
Author(s):  
Piyush Mehta ◽  
Vividha Dhapte
Keyword(s):  
Chemical Constituents ◽  
Herbal Medicines ◽  
Pharmacokinetic Profile ◽  
Pharmacokinetic Data ◽  
Therapeutic Effects ◽  
Traditional Chinese Medicines ◽  
Herbal Drug ◽  
Major Drawback ◽  
Chinese Medicines ◽  
Wide Range

Herbal medicines are the oldest and most widely used form of treatment for welfare of mankind. Herbal medicines possess strong reputation as complementary treatment across the globe due to their easy accessibility and safety. Particularly traditional Chinese medicines (TCM) are very popular due to their desirable therapeutic effects. They already have been proven for their remarkable potential in treatment of wide range of disease ailments. The major drawback in using herbal medicines is lack of standardisation aspects due to the complexity of chemical constituents. Pharmacokinetics study of such medicines helps forecast a range of events related to efficacy, safety, and toxicity profile of them. Apart from this, pharmacokinetics studies also recommended by various regulatory agencies during diverse stages of herbal drug development. Thus it is highly essential to have knowledge about the pharmacokinetic properties of any herbal drug. Thus it was thought that it will be worthwhile to compile the pharmacokinetic data of TCM which will be helpful for the researchers involved in further research on TCM. To portray entire picture about absorption, distribution, metabolism, and excretion (ADME) of some TCM, this well-designed scientific review covers the pharmacokinetic profile of 50 TCM available from 2003 and onwards.

scholarly journals Effect of extracts of traditional Chinese medicines on anti-tyrosinase and antioxidant activities

2015 ◽  
Vol 9 (48) ◽  
pp. 1131-1138 ◽  
Author(s):  
Hsieh Ting Fang ◽  
Chang Yaw Nan ◽  
Liu Bing Lan ◽  
Hsieh Ting Fang ◽  
Chang Yaw Nan ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines

scholarly journals Evaluation of extraction methods for pharmacologically active compounds from anticonvulsant traditional Chinese medicines: Gou Teng, Tian Ma, Jiang Can using DART-TOF-MS

2021 ◽  
Vol 13 (7) ◽  
pp. 884-893
Author(s):  
Kimberly N. Karin ◽  
Justin L. Poklis ◽  
Michelle R. Peace
Keyword(s):  
Extraction Methods ◽  
Rapid Analysis ◽  
Traditional Chinese Medicines ◽  
Microwave Assisted Extraction ◽  
Chinese Medicines ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Pharmacologically Active ◽  
Pharmacologically Active Compounds ◽  
Tof Ms

With the popularity of natural products, rapid analysis of pharmacologically active analytes from natural matrices is critical for public health. Microwave-assisted extraction with DART-MS provides efficient analysis of analytes from herbal matrices.

scholarly journals A Systematic Review of Antiaging Effects of 23 Traditional Chinese Medicines

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Lixin Wang ◽  
Xu Zuo ◽  
Zhuoer Ouyang ◽  
Ping Qiao ◽  
Fang Wang
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Herbal Medicines ◽  
Traditional Chinese Medicines ◽  
Active Components ◽  
Chinese Herbal Medicines ◽  
Chinese Medicines ◽  
Chinese Herbal ◽  
Body Development ◽  
Traditional Chinese Herbal Medicines

Background. Aging is an inevitable stage of body development. At the same time, aging is a major cause of cancer, cardiovascular disease, and neurodegenerative diseases. Chinese herbal medicine is a natural substance that can effectively delay aging and is expected to be developed as antiaging drugs in the future. Aim of the review. This paper reviews the antiaging effects of 23 traditional Chinese herbal medicines or their active components. Materials and methods. We reviewed the literature published in the last five years on Chinese herbal medicines or their active ingredients and their antiaging role obtained through the following databases: PubMed, EMBASE, Scopus, and Web of Science. Results. A total of 2485 papers were found, and 212 papers were screened after removing the duplicates and reading the titles. Twenty-three studies met the requirements of this review and were included. Among these studies, 13 articles used Caenorhabditis elegans as the animal model, and 10 articles used other animal models or cell lines. Conclusion. Chinese herbal medicines or their active components play an antiaging role by regulating genes related to aging through a variety of signaling pathways. Chinese herbal medicines are expected to be developed as antiaging drugs or used in the medical cosmetology industry.

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