scholarly journals A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

2016 ◽  
Vol 2016 ◽  
pp. 1-31 ◽  
Author(s):  
Piyush Mehta ◽  
Vividha Dhapte
Keyword(s):  
Chemical Constituents ◽  
Herbal Medicines ◽  
Pharmacokinetic Profile ◽  
Pharmacokinetic Data ◽  
Therapeutic Effects ◽  
Traditional Chinese Medicines ◽  
Herbal Drug ◽  
Major Drawback ◽  
Chinese Medicines ◽  
Wide Range

Herbal medicines are the oldest and most widely used form of treatment for welfare of mankind. Herbal medicines possess strong reputation as complementary treatment across the globe due to their easy accessibility and safety. Particularly traditional Chinese medicines (TCM) are very popular due to their desirable therapeutic effects. They already have been proven for their remarkable potential in treatment of wide range of disease ailments. The major drawback in using herbal medicines is lack of standardisation aspects due to the complexity of chemical constituents. Pharmacokinetics study of such medicines helps forecast a range of events related to efficacy, safety, and toxicity profile of them. Apart from this, pharmacokinetics studies also recommended by various regulatory agencies during diverse stages of herbal drug development. Thus it is highly essential to have knowledge about the pharmacokinetic properties of any herbal drug. Thus it was thought that it will be worthwhile to compile the pharmacokinetic data of TCM which will be helpful for the researchers involved in further research on TCM. To portray entire picture about absorption, distribution, metabolism, and excretion (ADME) of some TCM, this well-designed scientific review covers the pharmacokinetic profile of 50 TCM available from 2003 and onwards.

scholarly journals Comparative effects of traditional Chinese and Western migraine medicines in an animal model of nociceptive trigeminovascular activation

Cephalalgia ◽  
2017 ◽  
Vol 38 (7) ◽  
pp. 1215-1224 ◽  
Author(s):  
Yonglie Zhao ◽  
Margarida Martins-Oliveira ◽  
Simon Akerman ◽  
Peter J Goadsby
Keyword(s):  
Clinical Trial Data ◽  
Preventive Treatment ◽  
Pharmacokinetic Profile ◽  
Neuronal Firing ◽  
Migraine Treatment ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Potential Efficacy ◽  
Trigeminal Activation

Background Migraine is a highly prevalent and disabling disorder of the brain with limited therapeutic options, particularly for preventive treatment. There is a need to identify novel targets and test their potential efficacy in relevant preclinical migraine models. Traditional Chinese medicines have been used for millennia and may offer avenues for exploration. Methods We evaluated two traditional Chinese medicines, gastrodin and ligustrazine, and compared them to two Western approaches with propranolol and levetiracetam, one effective and one ineffective, in an established in vivo rodent model of nociceptive durovascular trigeminal activation. Results Intravenous gastrodin (30 and 100 mg/kg) significantly inhibited nociceptive dural-evoked neuronal firing in the trigeminocervical complex. Ligustrazine (10 mg/kg) and propranolol (3 mg/kg) also significantly inhibited dural-evoked trigeminocervical complex responses, although the timing of responses of ligustrazine does not match its pharmacokinetic profile. Levetiracetam had no effects on trigeminovascular responses. Conclusion Our data suggest gastrodin has potential as an anti-migraine treatment, whereas ligustrazine seems less promising. Interestingly, in line with clinical trial data, propranolol was effective and levetiracetam not. Exploration of the mechanisms and modelling effects of Chinese traditional therapies offers novel route for drug discovery in migraine.

scholarly journals UHPLC-ESI-Q-TOF-MS/MS analysis, antioxidant activity combined fingerprints for quality consistency evaluation of compound liquorice tablets

RSC Advances ◽  
2018 ◽  
Vol 8 (49) ◽  
pp. 27661-27673 ◽  
Author(s):  
Yujing Zhang ◽  
Chao Wang ◽  
Fangliang Yang ◽  
Zhe Yang ◽  
Fangren Wang ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Herbal Medicines ◽  
Detection Technique ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Ms Analysis ◽  
Consistency Evaluation ◽  
Tof Ms

Traditional Chinese medicines (TCM)/herbal medicines (HM) are too complicated to comprehensively investigate their quality consistency effectively with a single detection technique.

scholarly journals Effect of Different Post-Harvest Processing Methods on the Chemical Constituents of Notopterygium franchetii by an UHPLC-QTOF-MS-MS Metabolomics Approach

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3188 ◽  
Author(s):  
Su ◽  
Wu ◽  
Li ◽  
Huang ◽  
Liu ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Herbal Medicines ◽  
Chemical Components ◽  
Drying Methods ◽  
Bioactive Constituents ◽  
Chemical Changes ◽  
Processing Methods ◽  
Post Harvest ◽  
Hot Air ◽  
Wide Range

Notopterygium franchetii is a herb used in traditional Chinese medicine, where it is known as qianghuo. Its bioactive qualities are influenced by the post-harvest processing methods used (such as drying). However, changes in chemical components according to the drying method are unknown. Fresh roots and rhizomes of N. franchetii were subjected to seven drying methods. Chromatography-mass spectrometry combined with targeted and untargeted analyses were used to investigate relationships between drying methods and chemical concentrations. According to targeted evaluations of the six main bioactive constituents, their total contents decreased significantly in all drying methods. Hierarchical clustering analysis of the drying methods and total metabolome detected 30 chemical constituents, for which heap maps were obtained. Hot air drying was the best processing method, producing the least chemical changes at the lowest cost, while shade drying caused the greatest chemical changes. In conclusion, the wide range of chemical changes in N. franchetii caused by drying was investigated. Such changes potentially affect the quality of herbal medicines.

scholarly journals Bacopa Monnieri: A Wonder Drug Changing Fortune of People

2017 ◽  
Vol 5 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Kriti Rai ◽  
Nirmala Gupta ◽  
Lakshya Dharamdasani ◽  
Pallavi Nair ◽  
Prerna Bodhankar
Keyword(s):  
Chemical Constituents ◽  
Bacopa Monnieri ◽  
Phytochemical Analysis ◽  
Therapeutic Effects ◽  
Herbal Products ◽  
Biochemical Compounds ◽  
Wide Range ◽  
Low Toxicity ◽  
Wonder Drug ◽  
Memory Enhancer

In recent times, the use of herbal products has increased enormously across the globe. Numerous natural products such as those isolated from plants have been evaluated as therapeutics for the treatment of variety of diseases. Bacopa monnieri also referred to as water hyssop and “Brahmi,” has been used in the Ayurvedic system of medicine since time immemorial. It belongs to the family Scrophulariaceae and is an annual creeping plant found in wet, damp, and marshy areas. Phytochemical analysis of BM extracts revealed the presence of various biochemical compounds such as alkaloids, bacosides, flavonoids, glycosides, triterpenoids and saponins etc. The major therapeutic chemical constituents of this plant identified through various researches are the triterpenoids saponins, bacosides. Bacoside A has been recognized as the chief component responsible for therapeutic effects.  BM is conventionally used for diverse ailments, but is best known as memory enhancer. A vast range of studies using methanolic and ethanolic extracts of BM have shown its effect in treatment of wide range of diseases like diabetes, depression, cancer, inflammation etc. BM appears to demonstrate low toxicity in various rat, mice models including humans however, long-term studies of toxicity in humans still need to study in great details. This review focuses on the studies that have traced both pharmacological and phytochemical properties of plant Bacopa monnieri covering wide range of its effect on anti- depression, anti-inflammatory, anti-oxidative amongst many others which can surely help in betterment of mankind.Int. J. Appl. Sci. Biotechnol. Vol 5(2): 127-132

Chemical Constituents, Quality Control, and Bioactivity of Epimedii Folium (Yinyanghuo)

2015 ◽  
Vol 43 (05) ◽  
pp. 783-834 ◽  
Author(s):  
Xiao-Jia Chen ◽  
Zheng-Hai Tang ◽  
Xi-Wen Li ◽  
Cai-Xiang Xie ◽  
Jin-Jian Lu ◽  
...  
Keyword(s):  
Quality Control ◽  
Nervous System ◽  
Cardiovascular Diseases ◽  
Bone Formation ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Traditional Chinese Medicines ◽  
Active Components ◽  
Chinese Medicines ◽  
Anticancer Effects

Epimedii Folium (Yinyanghuo in Chinese) is one of the most commonly used traditional Chinese medicines. Its main active components are flavonoids, which exhibit multiple biological activities, such as promotion of bone formation and sexual function, protection of the nervous system, and prevention of cardiovascular diseases. Flavonoids also show anti-inflammatory and anticancer effects. Various effective methods, including genetic and chemical approaches, have been developed for the quality control of Yinyanghuo. In this review, the studies conducted in the last decade about the chemical constituents, quality control, and bioactivity of Yinyanghuo are summarized and discussed.

scholarly journals Impact of herbal drugs and its clinical application

2019 ◽  
Vol 10 (2) ◽  
pp. 1340-1345
Author(s):  
Vetriselvan Subramaniyan ◽  
Saminathan Kayarohanam ◽  
Ashok Kumar J ◽  
Vinoth Kumarasamy
Keyword(s):  
Health Care Professionals ◽  
Herbal Medicines ◽  
Drug Formulation ◽  
Therapeutic Effects ◽  
Clinical Use ◽  
Herbal Drugs ◽  
Herbal Drug ◽  
Alternative Medicines ◽  
Ancient Times ◽  
The Impact

Since ancient times until now exploring the importance of herbal medicines to treat the variety of diseases. Currently the herbal medicines searching for health, wellness and aim to achieve effective treatment without much side effect. Recent days the impact of herbal medicines well established even herbal treatment is one of the alternative medicines for most of the diseases such as hyperlipidemia, diabetes mellitus etc. Medicinal plants always have been rich sources of bioactive compounds, and that will be very helpful to human health. The reasons for herbal medicines attracted by the health care professionals and common individuals, including concern about confidence and safety of drugs. Allopathic medicines have many side effects and sometimes failing to treat and most of the herbal drugs proven better therapeutic effects without any major adverse effects. With the demand for phytomedicine user, this review highlights modern herbal drug formulation and its clinical use.

Monitoring quality consistency of Ixeris sonchifolia (Bunge) Hance injection by integrating UV spectroscopic fingerprints, a multi-wavelength fusion fingerprint method, antioxidant activities and UHPLC/Q-TOF-MS

RSC Advances ◽  
2016 ◽  
Vol 6 (90) ◽  
pp. 87616-87627 ◽  
Author(s):  
Lanping Yang ◽  
Xiuman Xie ◽  
Liu Yang ◽  
Jing Zhang ◽  
Guoxiang Sun
Keyword(s):  
Antioxidant Activities ◽  
Herbal Medicines ◽  
Detection Technique ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Multi Wavelength ◽  
Ixeris Sonchifolia ◽  
Monitoring Quality ◽  
Tof Ms

Traditional Chinese medicines/herbal medicines (TCM/HM) are too complicated mixture systems to investigate their quality consistency effectively using a single detection technique.

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