Hydroxyl radical scavenging by cerium oxide nanoparticles improves Arabidopsis salinity tolerance by enhancing leaf mesophyll potassium retention

2018 ◽  
Vol 5 (7) ◽  
pp. 1567-1583 ◽  
Author(s):  
Honghong Wu ◽  
Lana Shabala ◽  
Sergey Shabala ◽  
Juan Pablo Giraldo
Keyword(s):  
Crop Yield ◽  
Salinity Tolerance ◽  
Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Plant Tolerance ◽  
Ros Scavenging ◽  
Leaf Mesophyll ◽  
Potassium Retention ◽  
Tolerance To Salinity

Nanoceria ROS scavenging is a key tool for understanding and improving plant tolerance to salinity, a stress that severely limits crop yield worldwide.

scholarly journals In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1565 ◽  
Author(s):  
Turin-Moleavin ◽  
Fifere ◽  
Lungoci ◽  
Rosca ◽  
Coroaba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Iron Oxide ◽  
Cerium Oxide ◽  
Chemical Activation ◽  
Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

Background. Cerium oxide nanoparticles present the mimetic activity of superoxide dismutase, being able to inactivate the excess of reactive oxygen species (ROS) correlated with a large number of pathologies, such as stents restenosis and the occurrence of genetic mutations that can cause cancer. This study presents the synthesis and biological characterisation of nanoconjugates based on nanoparticles of iron oxide interconnected with cerium oxide conjugates. Methods. The synthesis of magnetite-nanoceria nanoconjugates has been done in several stages, where the key to the process is the coating of nanoparticles with polyethyleneimine and its chemical activation-reticulation with glutaraldehyde. The nanoconjugates are characterised by several techniques, and the antioxidant activity was evaluated in vitro and in vivo. Results. Iron oxide nanoparticles interconnected with cerium oxide nanoparticles were obtained, having an average diameter of 8 nm. Nanoconjugates prove to possess superparamagnetic properties and the saturation magnetisation varies with the addition of diamagnetic components in the system, remaining within the limits of biomedical applications. In vitro free-radical scavenging properties of nanoceria are improved after the coating of nanoparticles with polyethylenimine and conjugation with magnetite nanoparticles. In vivo studies reveal increased antioxidant activity in all organs and fluids collected from mice, which demonstrates the ability of the nanoconjugates to reduce oxidative stress. Conclusion. Nanoconjugates possess magnetic properties, being able to scavenge free radicals, reducing the oxidative stress. The combination of the two properties mentioned above makes them excellent candidates for theranostic applications.

Size- and defect-controlled anti-oxidant enzyme mimetic and radical scavenging properties of cerium oxide nanoparticles

2018 ◽  
Vol 42 (23) ◽  
pp. 18810-18823 ◽  
Author(s):  
G. Vinothkumar ◽  
P. Arunkumar ◽  
Arun Mahesh ◽  
Arunkumar Dhayalan ◽  
K. Suresh Babu
Keyword(s):  
Enzymatic Activity ◽  
Cerium Oxide ◽  
Oxidase Activity ◽  
Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Selective Activation ◽  
Enzyme Mimetic ◽  
Anti Oxidant ◽  
Radical Scavenging Properties

Improved enzymatic activity and concentration-dependent selective activation of peroxidase and oxidase activity of combustion-synthesized nanoceria.

scholarly journals Different approaches to synthesise cerium oxide nanoparticles and their corresponding physical characteristics, ROS scavenging and anti-inflammatory capabilities

2021 ◽  
Author(s):  
Yuao Wu ◽  
Hang Thu Ta
Keyword(s):  
Cerium Oxide ◽  
Physical Characteristics ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Biological Applications ◽  
Ros Scavenging ◽  
Trivalent Cerium ◽  
Anti Inflammatory ◽  
Tetravalent Cerium

The biological applications of cerium oxide nanoparticles (nanoceria) have received extensive attention in recent decades. The coexistence of trivalent cerium and tetravalent cerium on the surface of nanoceria allows the...

scholarly journals Study of in vitro and in vivo free radical scavenging activity for radioprotection of cerium oxide nanoparticles

2018 ◽  
Vol 15 (35) ◽  
pp. 40-47
Author(s):  
Asia H. Al-Mashhadani
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Scavenging Activity

Nanoceria have shown numerous unique characteristics, such as biocompatibility and are excellent agents for biological applications. The aim of this study is to investigate cerium oxide nanoparticles for 2, 2- diphenyl-1-picryl-hydrazyl-hydrate (DPPH) free radical scavenging activity and their ability to offer protection against ionizing radiation. In vitro antioxidant activity study of nanoceria particles has shown good free radical scavenging activity for DPPH radical assayed within a concentration range of 0.01 to 0.05 g/l, at higher concentrations of nanoparticles showed reverse trend in absorbance and inhibition indicating this finite rang of concentration is suitable for scavenging free radicals, also nanoparticles were found to have significant antioxidant capacity and thus can be used as potential radical scavenger against deleterious damages caused by the free radicals. The results of histopathological examination showed effectiveness of CeO2 nanoparticles in radioprotection of skin cells in animal models during radiation exposure.

Novel synthesis of cerium oxide nanoparticles for free radical scavenging

Nanomedicine ◽  
2007 ◽  
Vol 2 (3) ◽  
pp. 325-332 ◽  
Author(s):  
Yi-Yang Tsai ◽  
Jose Oca-Cossio ◽  
Kristina Agering ◽  
Nicholas E Simpson ◽  
Mark A Atkinson ◽  
...  
Keyword(s):  
Free Radical ◽  
Cerium Oxide ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Novel Synthesis

scholarly journals Cerium Oxide Nanoparticles Improve Cotton Salt Tolerance by Enabling Better Ability to Maintain Cytosolic K+/Na+ Ratio

2021 ◽  
Author(s):  
Jiahao Liu ◽  
Guangjing Li ◽  
Linlin Chen ◽  
Jiangjiang Gu ◽  
Honghong Wu ◽  
...  
Keyword(s):  
Salt Tolerance ◽  
Cerium Oxide ◽  
Salinity Stress ◽  
Agricultural Production ◽  
Cerium Oxide Nanoparticles ◽  
Control Group ◽  
Oxide Nanoparticles ◽  
Plant Tolerance ◽  
True Leaf ◽  
Cotton Plants

Abstract BackgroundSalinity is a worldwide factor limiting the agricultural production. Cotton is an important cash crop; however, its yield and product quality are negatively affected by salinity. Using nanomaterials such as cerium oxide nanoparticles (nanoceria) to improve plant tolerance to stresses, e.g. salinity, is an emerged approach in agricultural production. Nevertheless, to date, our knowledge about the role of nanoceria in cotton salt response and the behind mechanisms is still rare. ResultsWe found that PNC (poly acrylic acid coated nanoceria) helped to improve cotton plant tolerance to salinity, showing the better phenotypic performance, the higher chlorophyll content and biomass, and the better photosynthetic performance in PNC treated cotton plants than the control group. Under salinity stress, in consistent to the results of the enhanced antioxidant enzyme activities, PNC treated cotton plants showed significant lower MDA content and ROS level than the control group, both in the first and second true leaf. Further experiments showed that under salinity stress, PNC treated cotton plants had significant higher cytosolic K+ and lower cytosolic Na+ fluorescent intensity in both the first and second true leaf than the control group. This is further confirmed by the leaf ion content analysis, showed that PNC treated cotton plants maintained significant higher leaf K+ and lower leaf Na+ content, and thus the higher K+/Na+ ratio than the control plants under salinity. Whereas no significant increase of vacuolar Na+ intensity was observed in PNC treated plants than the control under salinity, suggesting that PNC enhanced leaf K+ retention and leaf Na+ exclusion, but not leaf vacuolar Na+ sequestration are the main mechanisms behind the PNC improved cotton salt tolerance. qPCR results showed that under salinity stress, the modulation of HKT1 but not SOS1 refers more to the PNC improved cotton leaf Na+ exclusion than the control. ConclusionsNanoceria enhanced leaf K+ retention and Na+ exclusion, but not vacuolar Na+ sequestration are the main mechanisms behind the nanoceria improved cotton salt tolerance. Our results add more knowledge for better understanding the complexity of plant-nanoceria interaction in terms of nano-enabled plant stress tolerance.

Ligand-mediated reversal of the oxidation state dependent ROS scavenging and enzyme mimicking activity of ceria nanoparticles

2018 ◽  
Vol 54 (99) ◽  
pp. 13973-13976 ◽  
Author(s):  
Vaishwik Patel ◽  
Mandeep Singh ◽  
Edwin L. H. Mayes ◽  
Abraham Martinez ◽  
Vaithiyalingam Shutthanandan ◽  
...  
Keyword(s):  
Enzymatic Activity ◽  
Cerium Oxide ◽  
Oxidation State ◽  
Phosphine Ligands ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Ceria Nanoparticles ◽  
Ros Scavenging ◽  
State Dependent ◽  
Enzyme Mimicking

Enzymatic activity of cerium oxide nanoparticles modified by phosphine ligands.

scholarly journals Cerium Oxide Nanoparticles: A Brief Review of Their Synthesis Methods and Biomedical Applications

Antioxidants ◽  
2018 ◽  
Vol 7 (8) ◽  
pp. 97 ◽  
Author(s):  
Atul Dhall ◽  
William Self
Keyword(s):  
Cerium Oxide ◽  
Biomedical Applications ◽  
Antioxidant Properties ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Ros Scavenging ◽  
Corona Formation

Cerium oxide nanoparticles (CeNPs) exhibit antioxidant properties both in vitro and in vivo. This is due to the self-regeneration of their surface, which is based on redox-cycling between 3+ and 4+ states for cerium, in response to their immediate environment. Additionally, oxygen vacancies in the lattice structure allow for alternating between CeO2 and CeO2−x during redox reactions. Research to identify and characterize the biomedical applications of CeNPs has been heavily focused on investigating their use in treating diseases that are characterized by higher levels of reactive oxygen species (ROS). Although the bio-mimetic activities of CeNPs have been extensively studied in vitro, in vivo interactions and associated protein corona formation are not well understood. This review describes: (1) the methods of synthesis for CeNPs, including the recent green synthesis methods that offer enhanced biocompatibility and a need for establishing a reference CeNP material for consistency across studies; (2) their enzyme-mimetic activities, with a focus on their antioxidant activities; and, (3) recent experimental evidence that demonstrates their ROS scavenging abilities and their potential use in personalized medicine.

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