scholarly journals Cerium Oxide Nanoparticles: A Brief Review of Their Synthesis Methods and Biomedical Applications

Antioxidants ◽  
2018 ◽  
Vol 7 (8) ◽  
pp. 97 ◽  
Author(s):  
Atul Dhall ◽  
William Self
Keyword(s):  
Cerium Oxide ◽  
Biomedical Applications ◽  
Antioxidant Properties ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Ros Scavenging ◽  
Corona Formation

Cerium oxide nanoparticles (CeNPs) exhibit antioxidant properties both in vitro and in vivo. This is due to the self-regeneration of their surface, which is based on redox-cycling between 3+ and 4+ states for cerium, in response to their immediate environment. Additionally, oxygen vacancies in the lattice structure allow for alternating between CeO2 and CeO2−x during redox reactions. Research to identify and characterize the biomedical applications of CeNPs has been heavily focused on investigating their use in treating diseases that are characterized by higher levels of reactive oxygen species (ROS). Although the bio-mimetic activities of CeNPs have been extensively studied in vitro, in vivo interactions and associated protein corona formation are not well understood. This review describes: (1) the methods of synthesis for CeNPs, including the recent green synthesis methods that offer enhanced biocompatibility and a need for establishing a reference CeNP material for consistency across studies; (2) their enzyme-mimetic activities, with a focus on their antioxidant activities; and, (3) recent experimental evidence that demonstrates their ROS scavenging abilities and their potential use in personalized medicine.

Cerium Oxide Nanoparticles are Nontoxic for Mouse Embryogenesis In Vitro and In Vivo

2017 ◽  
Vol 13 ◽  
pp. 248-254 ◽  
Author(s):  
Alexander S. Chernov ◽  
Dmitry A. Reshetnikov ◽  
Anton L. Popov ◽  
Nelly R. Popova ◽  
Irina V. Savintseva ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Reproductive System ◽  
Biomedical Applications ◽  
Complex Analysis ◽  
Mouse Embryos ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Wide Range

Cerium oxide nanoparticles (nanoceria) are considered as one of the most promising nanomaterials for biomedical applications. Complex analysis of cytotoxicity, including the assessment of effects on the reproductive system, is required for development of new biomedical materials. In this study, we investigated the effects of ultra-small citrate-stabilized cerium oxide nanoparticles on the development of mouse embryos in vitro and embryogenesis process in vivo. We have shown that nanoceria in a wide range of concentrations do not exert a toxic effect on the development of 2-cell embryos and embryogenesis.

scholarly journals In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1565 ◽  
Author(s):  
Turin-Moleavin ◽  
Fifere ◽  
Lungoci ◽  
Rosca ◽  
Coroaba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Iron Oxide ◽  
Cerium Oxide ◽  
Chemical Activation ◽  
Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

Background. Cerium oxide nanoparticles present the mimetic activity of superoxide dismutase, being able to inactivate the excess of reactive oxygen species (ROS) correlated with a large number of pathologies, such as stents restenosis and the occurrence of genetic mutations that can cause cancer. This study presents the synthesis and biological characterisation of nanoconjugates based on nanoparticles of iron oxide interconnected with cerium oxide conjugates. Methods. The synthesis of magnetite-nanoceria nanoconjugates has been done in several stages, where the key to the process is the coating of nanoparticles with polyethyleneimine and its chemical activation-reticulation with glutaraldehyde. The nanoconjugates are characterised by several techniques, and the antioxidant activity was evaluated in vitro and in vivo. Results. Iron oxide nanoparticles interconnected with cerium oxide nanoparticles were obtained, having an average diameter of 8 nm. Nanoconjugates prove to possess superparamagnetic properties and the saturation magnetisation varies with the addition of diamagnetic components in the system, remaining within the limits of biomedical applications. In vitro free-radical scavenging properties of nanoceria are improved after the coating of nanoparticles with polyethylenimine and conjugation with magnetite nanoparticles. In vivo studies reveal increased antioxidant activity in all organs and fluids collected from mice, which demonstrates the ability of the nanoconjugates to reduce oxidative stress. Conclusion. Nanoconjugates possess magnetic properties, being able to scavenge free radicals, reducing the oxidative stress. The combination of the two properties mentioned above makes them excellent candidates for theranostic applications.

scholarly journals Cerium Oxide Nanoparticles Improve Outcome after In Vitro and In Vivo Mild Traumatic Brain Injury

2020 ◽  
Vol 37 (12) ◽  
pp. 1452-1462 ◽  
Author(s):  
Zachary S. Bailey ◽  
Eric Nilson ◽  
John A. Bates ◽  
Adewole Oyalowo ◽  
Kevin S. Hockey ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cerium Oxide ◽  
Mild Traumatic Brain Injury ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Improve Outcome

Radioprotective effects of ultra-small citrate-stabilized cerium oxide nanoparticles in vitro and in vivo

RSC Advances ◽  
2016 ◽  
Vol 6 (108) ◽  
pp. 106141-106149 ◽  
Author(s):  
A. L. Popov ◽  
S. I. Zaichkina ◽  
N. R. Popova ◽  
O. M. Rozanova ◽  
S. P. Romanchenko ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Action Mechanisms ◽  
Radioprotective Action

Different radioprotective action mechanisms of CeO2 nanoparticles in vitro and in vivo are demonstrated and discussed.

scholarly journals Cerium Oxide Nanoparticles Protect against Oxidant Injury and Interfere with Oxidative Mediated Kinase Signaling in Human-Derived Hepatocytes

2019 ◽  
Vol 20 (23) ◽  
pp. 5959 ◽  
Author(s):  
Silvia Carvajal ◽  
Meritxell Perramón ◽  
Gregori Casals ◽  
Denise Oró ◽  
Jordi Ribera ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Viability ◽  
Cerium Oxide ◽  
Antioxidant Properties ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxidant Injury ◽  
Ros Scavenging ◽  
Alcoholic Fatty Liver ◽  
The Impact

Cerium oxide nanoparticles (CeO2NPs) possess powerful antioxidant properties, thus emerging as a potential therapeutic tool in non-alcoholic fatty liver disease (NAFLD) progression, which is characterized by a high presence of reactive oxygen species (ROS). The aim of this study was to elucidate whether CeO2NPs can prevent or attenuate oxidant injury in the hepatic human cell line HepG2 and to investigate the mechanisms involved in this phenomenon. The effect of CeO2NPs on cell viability and ROS scavenging was determined, the differential expression of pro-inflammatory and oxidative stress-related genes was analyzed, and a proteomic analysis was performed to assess the impact of CeO2NPs on cell phosphorylation in human hepatic cells under oxidative stress conditions. CeO2NPs did not modify HepG2 cell viability in basal conditions but reduced H2O2- and lipopolysaccharide (LPS)-induced cell death and prevented H2O2-induced overexpression of MPO, PTGS1 and iNOS. Phosphoproteomic analysis showed that CeO2NPs reverted the H2O2-mediated increase in the phosphorylation of peptides related to cellular proliferation, stress response, and gene transcription regulation, and interfered with H2O2 effects on mTOR, MAPK/ERK, CK2A1 and PKACA signaling pathways. In conclusion, CeO2NPs protect HepG2 cells from cell-induced oxidative damage, reducing ROS generation and inflammatory gene expression as well as regulation of kinase-driven cell survival pathways.

scholarly journals Cerium oxide nanoparticles improve liver regeneration after acetaminophen-induced liver injury and partial hepatectomy in rats

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Bernat Córdoba-Jover ◽  
Altamira Arce-Cerezo ◽  
Jordi Ribera ◽  
Montse Pauta ◽  
Denise Oró ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Regeneration ◽  
Cerium Oxide ◽  
Partial Hepatectomy ◽  
Experimental Models ◽  
Cerium Oxide Nanoparticles ◽  
Hepatic Regeneration ◽  
Oxide Nanoparticles ◽  
Acetyl Cysteine

Abstract Background and aims Cerium oxide nanoparticles are effective scavengers of reactive oxygen species and have been proposed as a treatment for oxidative stress-related diseases. Consequently, we aimed to investigate the effect of these nanoparticles on hepatic regeneration after liver injury by partial hepatectomy and acetaminophen overdose. Methods All the in vitro experiments were performed in HepG2 cells. For the acetaminophen and partial hepatectomy experimental models, male Wistar rats were divided into three groups: (1) nanoparticles group, which received 0.1 mg/kg cerium nanoparticles i.v. twice a week for 2 weeks before 1 g/kg acetaminophen treatment, (2) N-acetyl-cysteine group, which received 300 mg/kg of N-acetyl-cysteine i.p. 1 h after APAP treatment and (3) partial hepatectomy group, which received the same nanoparticles treatment before partial hepatectomy. Each group was matched with vehicle-controlled rats. Results In the partial hepatectomy model, rats treated with cerium oxide nanoparticles showed a significant increase in liver regeneration, compared with control rats. In the acetaminophen experimental model, nanoparticles and N-acetyl-cysteine treatments decreased early liver damage in hepatic tissue. However, only the effect of cerium oxide nanoparticles was associated with a significant increment in hepatocellular proliferation. This treatment also reduced stress markers and increased cell cycle progression in hepatocytes and the activation of the transcription factor NF-κB in vitro and in vivo. Conclusions Our results demonstrate that the nanomaterial cerium oxide, besides their known antioxidant capacities, can enhance hepatocellular proliferation in experimental models of liver regeneration and drug-induced hepatotoxicity.

Drosophila melanogaster as an in vivo model to study the potential toxicity of cerium oxide nanoparticles

2019 ◽  
Vol 490 ◽  
pp. 70-80 ◽  
Author(s):  
Vignesh Sundararajan ◽  
Pallavi Dan ◽  
Ajay Kumar ◽  
G. Devanand Venkatasubbu ◽  
Sahoko Ichihara ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
In Vivo Model ◽  
Oxide Nanoparticles ◽  
Potential Toxicity

scholarly journals Physicochemical characterization and antioxidant properties of cerium oxide nanoparticles

2018 ◽  
Vol 1115 ◽  
pp. 032094 ◽  
Author(s):  
R A Vazirov ◽  
S Y Sokovnin ◽  
V G Ilves ◽  
I N Bazhukova ◽  
N Pizurova ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Antioxidant Properties ◽  
Physicochemical Characterization ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles
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