Size- and defect-controlled anti-oxidant enzyme mimetic and radical scavenging properties of cerium oxide nanoparticles

2018 ◽  
Vol 42 (23) ◽  
pp. 18810-18823 ◽  
Author(s):  
G. Vinothkumar ◽  
P. Arunkumar ◽  
Arun Mahesh ◽  
Arunkumar Dhayalan ◽  
K. Suresh Babu
Keyword(s):  
Enzymatic Activity ◽  
Cerium Oxide ◽  
Oxidase Activity ◽  
Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Selective Activation ◽  
Enzyme Mimetic ◽  
Anti Oxidant ◽  
Radical Scavenging Properties

Improved enzymatic activity and concentration-dependent selective activation of peroxidase and oxidase activity of combustion-synthesized nanoceria.

scholarly journals In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1565 ◽  
Author(s):  
Turin-Moleavin ◽  
Fifere ◽  
Lungoci ◽  
Rosca ◽  
Coroaba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Iron Oxide ◽  
Cerium Oxide ◽  
Chemical Activation ◽  
Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

Background. Cerium oxide nanoparticles present the mimetic activity of superoxide dismutase, being able to inactivate the excess of reactive oxygen species (ROS) correlated with a large number of pathologies, such as stents restenosis and the occurrence of genetic mutations that can cause cancer. This study presents the synthesis and biological characterisation of nanoconjugates based on nanoparticles of iron oxide interconnected with cerium oxide conjugates. Methods. The synthesis of magnetite-nanoceria nanoconjugates has been done in several stages, where the key to the process is the coating of nanoparticles with polyethyleneimine and its chemical activation-reticulation with glutaraldehyde. The nanoconjugates are characterised by several techniques, and the antioxidant activity was evaluated in vitro and in vivo. Results. Iron oxide nanoparticles interconnected with cerium oxide nanoparticles were obtained, having an average diameter of 8 nm. Nanoconjugates prove to possess superparamagnetic properties and the saturation magnetisation varies with the addition of diamagnetic components in the system, remaining within the limits of biomedical applications. In vitro free-radical scavenging properties of nanoceria are improved after the coating of nanoparticles with polyethylenimine and conjugation with magnetite nanoparticles. In vivo studies reveal increased antioxidant activity in all organs and fluids collected from mice, which demonstrates the ability of the nanoconjugates to reduce oxidative stress. Conclusion. Nanoconjugates possess magnetic properties, being able to scavenge free radicals, reducing the oxidative stress. The combination of the two properties mentioned above makes them excellent candidates for theranostic applications.

Cerium oxide nanoparticles and their importance in cell signaling pathways for predicting cellular behavior

Nanomedicine ◽  
2020 ◽  
Vol 15 (17) ◽  
pp. 1709-1718
Author(s):  
Atefeh Pesaraklou ◽  
Maryam M Matin
Keyword(s):  
Signaling Pathways ◽  
Cerium Oxide ◽  
Cellular Responses ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Signaling Proteins ◽  
Cellular Behavior ◽  
Anti Oxidant ◽  
Different Response ◽  
Cell Signaling Pathways

Cerium oxide nanoparticles (CeO2-NPs) have prolifically attracted immense interest of researchers due to their prominent anti-oxidant nature. However, these characteristics are accompanied by some ambiguities in other studies reporting their oxidant and toxic properties. In this regard previous literature has pointed to the importance of the NPs morphology and environmental conditions as well as biomolecules that induce a different response by initiating a cascade of activities. Therefore, due to the fact that signaling proteins are key mediators in cellular responses, the cognizance of the CeO2-NP-targeted signaling pathways could facilitate predicting the cellular behavior and thus more efficient applications of these NPs for clinical purposes. Consequently, a comprehensive review is necessary in this field, to clarify the impacts of CeO2-NPs on various signaling pathways.

Behavior of nanoceria in biologically-relevant environments

2014 ◽  
Vol 1 (6) ◽  
pp. 516-532 ◽  
Author(s):  
Amit Kumar ◽  
Soumen Das ◽  
Prabhakaran Munusamy ◽  
William Self ◽  
Donald R. Baer ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Biological Research ◽  
Oxide Nanoparticles ◽  
Biologically Relevant ◽  
Anti Oxidant

Cerium oxide nanoparticles (nanoceria) have gained considerable attention in biological research due to their anti-oxidant like behaviour and regenerative nature.

Novel synthesis of cerium oxide nanoparticles for free radical scavenging

Nanomedicine ◽  
2007 ◽  
Vol 2 (3) ◽  
pp. 325-332 ◽  
Author(s):  
Yi-Yang Tsai ◽  
Jose Oca-Cossio ◽  
Kristina Agering ◽  
Nicholas E Simpson ◽  
Mark A Atkinson ◽  
...  
Keyword(s):  
Free Radical ◽  
Cerium Oxide ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Novel Synthesis

Poly(acrylic acid)-mediated synthesis of cerium oxide nanoparticles with variable oxidation state and their effect on regulating intracellular ROS level

2021 ◽  
Author(s):  
Xiaohui Ju ◽  
Marie Hubalek Kalbacova ◽  
Břetislav Šmíd ◽  
Viktor Johánek ◽  
Martin Janata ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Acrylic Acid ◽  
Cerium Oxide ◽  
Oxidation State ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Redox Enzyme ◽  
Enzyme Mimetic ◽  
Intracellular Ros

Cerium oxide nanoparticles (CeNPs) possess multiple redox enzyme mimetic activities to scavenge reactive oxygen species (ROS) as potential biomedicine. These enzymatic activities of CeNPs are closely related to their surface...

scholarly journals The Anti-oxidant and Anti-inflammatory Properties of Cerium Oxide Nanoparticles Synthesized Using Origanum majorana L. Leaf Extract

2019 ◽  
Vol 4 (3) ◽  
pp. 108-112
Author(s):  
Ali Es-haghi ◽  
Saynaz Aseyd Nezhad
Keyword(s):  
Free Radicals ◽  
Cerium Oxide ◽  
Leaf Extract ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Gene Expressions ◽  
Frap Assay ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Origanum Majorana

Introduction: Free radicals have singlet electron in their outer layer rendering them high reactivity against biomolecules (i.e., DNA, carbohydrates, proteins, and lipids). Oxidative stress is created when the production of free radicals exceeds their removal by antioxidant systems and is involved in the pathogenesis of several diseases such as diabetes, arthritis, inflammatory conditions, and various cancers. Regarding the therapeutic potential of nanoparticles (NPs) in human diseases, the purpose of this study was to synthesize cerium oxide NPs using Origanum majorana leaf extract. Methods: Cerium oxide nanoparticles (CeO2 -NPs) were synthesized using aqueous leaf extract of O. majorana. The sizes of NPs were characterized by a particle size analyzer. The antioxidant properties of the CeO2 -NPs were determined by Ferric-reducing antioxidant power (FRAP) assay. The anti-inflammatory effects of the NPs were also determined by measuring gene expressions of IL-1β and IL-10 using real-time polymerase chain reaction (PCR). Results: The CeO2 -NPs were successfully synthesized using O. majorana leaf extract. The results of FRAP assay showed that the anti-oxidant activities of CeO2 -NPs at concentrations of 50, 100, and 400 μg/mL were 75%, 77.1%, and 94.5%, respectively. Moreover, interleukin 10 (IL-10) gene expressions increased by 4.6 folds while the expression of IL-1β gene decreased by 0.75-fold in HUVECs. Conclusion: The CeO2 -NPs synthesized using the aqueous extract of O. majorana demonstrated antioxidant and anti-inflammatory properties. Therefore, these NPs can be used as potential therapeutic agents in medicine.

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