scholarly journals Different approaches to synthesise cerium oxide nanoparticles and their corresponding physical characteristics, ROS scavenging and anti-inflammatory capabilities

2021 ◽  
Author(s):  
Yuao Wu ◽  
Hang Thu Ta
Keyword(s):  
Cerium Oxide ◽  
Physical Characteristics ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Biological Applications ◽  
Ros Scavenging ◽  
Trivalent Cerium ◽  
Anti Inflammatory ◽  
Tetravalent Cerium

The biological applications of cerium oxide nanoparticles (nanoceria) have received extensive attention in recent decades. The coexistence of trivalent cerium and tetravalent cerium on the surface of nanoceria allows the...

Anti-inflammatory Properties of Cerium Oxide Nanoparticles

Small ◽  
2009 ◽  
Vol 5 (24) ◽  
pp. 2848-2856 ◽  
Author(s):  
Suzanne M. Hirst ◽  
Ajay S. Karakoti ◽  
Ron D. Tyler ◽  
Nammalwar Sriranganathan ◽  
Sudipta Seal ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Anti Inflammatory

Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti-inflammatory properties in rats with liver fibrosis

2016 ◽  
Vol 64 (3) ◽  
pp. 691-698 ◽  
Author(s):  
Denise Oró ◽  
Tetyana Yudina ◽  
Guillermo Fernández-Varo ◽  
Eudald Casals ◽  
Vedrana Reichenbach ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Fibrosis ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Anti Inflammatory

Controlling the surface chemistry of cerium oxide nanoparticles for biological applications

2016 ◽  
Vol 4 (19) ◽  
pp. 3195-3202 ◽  
Author(s):  
Ankur Gupta ◽  
Soumen Das ◽  
Craig J. Neal ◽  
Sudipta Seal
Keyword(s):  
Surface Chemistry ◽  
Cerium Oxide ◽  
Room Temperature ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Biological Applications

Room temperature doping of cerium oxide nanoparticles to control the surface chemistry for enhanced biocatalytic activity is proposed.

scholarly journals The Anti-oxidant and Anti-inflammatory Properties of Cerium Oxide Nanoparticles Synthesized Using Origanum majorana L. Leaf Extract

2019 ◽  
Vol 4 (3) ◽  
pp. 108-112
Author(s):  
Ali Es-haghi ◽  
Saynaz Aseyd Nezhad
Keyword(s):  
Free Radicals ◽  
Cerium Oxide ◽  
Leaf Extract ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Gene Expressions ◽  
Frap Assay ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Origanum Majorana

Introduction: Free radicals have singlet electron in their outer layer rendering them high reactivity against biomolecules (i.e., DNA, carbohydrates, proteins, and lipids). Oxidative stress is created when the production of free radicals exceeds their removal by antioxidant systems and is involved in the pathogenesis of several diseases such as diabetes, arthritis, inflammatory conditions, and various cancers. Regarding the therapeutic potential of nanoparticles (NPs) in human diseases, the purpose of this study was to synthesize cerium oxide NPs using Origanum majorana leaf extract. Methods: Cerium oxide nanoparticles (CeO2 -NPs) were synthesized using aqueous leaf extract of O. majorana. The sizes of NPs were characterized by a particle size analyzer. The antioxidant properties of the CeO2 -NPs were determined by Ferric-reducing antioxidant power (FRAP) assay. The anti-inflammatory effects of the NPs were also determined by measuring gene expressions of IL-1β and IL-10 using real-time polymerase chain reaction (PCR). Results: The CeO2 -NPs were successfully synthesized using O. majorana leaf extract. The results of FRAP assay showed that the anti-oxidant activities of CeO2 -NPs at concentrations of 50, 100, and 400 μg/mL were 75%, 77.1%, and 94.5%, respectively. Moreover, interleukin 10 (IL-10) gene expressions increased by 4.6 folds while the expression of IL-1β gene decreased by 0.75-fold in HUVECs. Conclusion: The CeO2 -NPs synthesized using the aqueous extract of O. majorana demonstrated antioxidant and anti-inflammatory properties. Therefore, these NPs can be used as potential therapeutic agents in medicine.

scholarly journals Anti-inflammatory and antioxidant effects of cerium oxide nanoparticles in human endothelial cells

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P4174-P4174 ◽  
Author(s):  
S. Del Turco ◽  
G. Ciofani ◽  
V. Cappello ◽  
T. Navarra ◽  
C. Caselli ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Human Endothelial Cells ◽  
Anti Inflammatory ◽  
Antioxidant Effects

Ligand-mediated reversal of the oxidation state dependent ROS scavenging and enzyme mimicking activity of ceria nanoparticles

2018 ◽  
Vol 54 (99) ◽  
pp. 13973-13976 ◽  
Author(s):  
Vaishwik Patel ◽  
Mandeep Singh ◽  
Edwin L. H. Mayes ◽  
Abraham Martinez ◽  
Vaithiyalingam Shutthanandan ◽  
...  
Keyword(s):  
Enzymatic Activity ◽  
Cerium Oxide ◽  
Oxidation State ◽  
Phosphine Ligands ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Ceria Nanoparticles ◽  
Ros Scavenging ◽  
State Dependent ◽  
Enzyme Mimicking

Enzymatic activity of cerium oxide nanoparticles modified by phosphine ligands.

scholarly journals Cerium Oxide Nanoparticles: A Brief Review of Their Synthesis Methods and Biomedical Applications

Antioxidants ◽  
2018 ◽  
Vol 7 (8) ◽  
pp. 97 ◽  
Author(s):  
Atul Dhall ◽  
William Self
Keyword(s):  
Cerium Oxide ◽  
Biomedical Applications ◽  
Antioxidant Properties ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Ros Scavenging ◽  
Corona Formation

Cerium oxide nanoparticles (CeNPs) exhibit antioxidant properties both in vitro and in vivo. This is due to the self-regeneration of their surface, which is based on redox-cycling between 3+ and 4+ states for cerium, in response to their immediate environment. Additionally, oxygen vacancies in the lattice structure allow for alternating between CeO2 and CeO2−x during redox reactions. Research to identify and characterize the biomedical applications of CeNPs has been heavily focused on investigating their use in treating diseases that are characterized by higher levels of reactive oxygen species (ROS). Although the bio-mimetic activities of CeNPs have been extensively studied in vitro, in vivo interactions and associated protein corona formation are not well understood. This review describes: (1) the methods of synthesis for CeNPs, including the recent green synthesis methods that offer enhanced biocompatibility and a need for establishing a reference CeNP material for consistency across studies; (2) their enzyme-mimetic activities, with a focus on their antioxidant activities; and, (3) recent experimental evidence that demonstrates their ROS scavenging abilities and their potential use in personalized medicine.

scholarly journals Cerium Oxide Nanoparticles Protect against Oxidant Injury and Interfere with Oxidative Mediated Kinase Signaling in Human-Derived Hepatocytes

2019 ◽  
Vol 20 (23) ◽  
pp. 5959 ◽  
Author(s):  
Silvia Carvajal ◽  
Meritxell Perramón ◽  
Gregori Casals ◽  
Denise Oró ◽  
Jordi Ribera ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Viability ◽  
Cerium Oxide ◽  
Antioxidant Properties ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxidant Injury ◽  
Ros Scavenging ◽  
Alcoholic Fatty Liver ◽  
The Impact

Cerium oxide nanoparticles (CeO2NPs) possess powerful antioxidant properties, thus emerging as a potential therapeutic tool in non-alcoholic fatty liver disease (NAFLD) progression, which is characterized by a high presence of reactive oxygen species (ROS). The aim of this study was to elucidate whether CeO2NPs can prevent or attenuate oxidant injury in the hepatic human cell line HepG2 and to investigate the mechanisms involved in this phenomenon. The effect of CeO2NPs on cell viability and ROS scavenging was determined, the differential expression of pro-inflammatory and oxidative stress-related genes was analyzed, and a proteomic analysis was performed to assess the impact of CeO2NPs on cell phosphorylation in human hepatic cells under oxidative stress conditions. CeO2NPs did not modify HepG2 cell viability in basal conditions but reduced H2O2- and lipopolysaccharide (LPS)-induced cell death and prevented H2O2-induced overexpression of MPO, PTGS1 and iNOS. Phosphoproteomic analysis showed that CeO2NPs reverted the H2O2-mediated increase in the phosphorylation of peptides related to cellular proliferation, stress response, and gene transcription regulation, and interfered with H2O2 effects on mTOR, MAPK/ERK, CK2A1 and PKACA signaling pathways. In conclusion, CeO2NPs protect HepG2 cells from cell-induced oxidative damage, reducing ROS generation and inflammatory gene expression as well as regulation of kinase-driven cell survival pathways.

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