scholarly journals Measuring viscosity inside mesoporous silica using protein-bound molecular rotor probe

2018 ◽  
Vol 20 (36) ◽  
pp. 23202-23213 ◽  
Author(s):  
Pegah S. Nabavi Zadeh ◽  
Milene Zezzi do Valle Gomes ◽  
Maria Abrahamsson ◽  
Anders E. C. Palmqvist ◽  
Björn Åkerman
Keyword(s):  
Mesoporous Silica ◽  
Fluorescence Spectroscopy ◽  
Effective Viscosity ◽  
Molecular Rotors ◽  
Molecular Rotor

Fluorescence spectroscopy of protein-bound molecular rotors Cy3 and Cy5 is used to monitor the effective viscosity inside the pores of two types of mesoporous silica (SBA-15 and MCF) with pore diameters between 8.9 and 33 nm.

scholarly journals Deciphering Multiple Critical Parameters of Polymeric Self-Assembly by Fluorescence Spectroscopy of a Single Molecular Rotor BODIPY-C12

2021 ◽  
Author(s):  
Ekaterina Lisitsyna ◽  
Alexander Efimov ◽  
Clémentine Depresle ◽  
Pierre Cauchois ◽  
Elina Vuorimaa-Laukkanen ◽  
...  
Keyword(s):  
Fluorescence Spectroscopy ◽  
Self Assembly ◽  
Critical Parameters ◽  
Molecular Rotor

Molecular Rotors as Reporters for Viscosity of Solutions of Collagen Like Peptides

2021 ◽  
Author(s):  
Christopher McTiernan ◽  
Matias Zuñiga-Bustos ◽  
Roberto Rosales-Rojas ◽  
Pablo Barrias ◽  
May Griffith ◽  
...  
Keyword(s):  
Steady State ◽  
Fluorometric Assay ◽  
Molecular Rotors ◽  
Molecular Rotor

We have studied the suitability of using a molecular rotor-based steady-state fluorometric assay for evaluating changes in both the conformation and the viscosity of collagen-like peptide solutions. Our results indicate...

Light-Activated Polymer-Coated Mesoporous Silica with Azobenzene Moiety for the Controlled Delivery of Guest Molecules

2020 ◽  
Vol 20 (11) ◽  
pp. 6935-6942
Author(s):  
Sang-Wook Chu ◽  
Sung Soo Park ◽  
Chang-Sik Ha
Keyword(s):  
Mesoporous Silica ◽  
Fluorescence Spectroscopy ◽  
Controlled Delivery ◽  
Time Resolved Fluorescence ◽  
Trans Isomers ◽  
Guest Molecules ◽  
Time Resolved ◽  
Acidic Solutions ◽  
Azobenzene Moiety ◽  
Light Activity

In this study, we have synthesized a light-activated polymer-coated mesoporous silica nanovalve with poly(trans-4-methacryloyloxyazobenzene-co-methylmethacrylic acid-co-vinyltrimethoxysilane) (PMMV) (MSNs/PMMV) for the controlled delivery of guest molecules. The hydrophobicity of azobenzene varies depending on the structure of each isomer. Typically, trans isomers are hydrophobic due to the aromatic ring, but they become more hydrophilic when they are changed to the cis confirmation. Using this concept, we introduced PMMV as a light active nanovalve on the mesoporous silica. To optimize the coating of the light-activated polymer on mesoporous silica, we investigated the conformational change of PMMV in solutions at various pHs. PMMV has a dot-like morphology in acidic solutions under pH 4, but sheet-like morphology in solutions at pH over 4. We investigated the nanovalve behavior of MSNs/PMMV by introducing propidium iodide (PI) as guest molecules. Time-resolved fluorescence spectroscopy showed the excellent light activity of PMMV for open pores. The new PMMV-coated mesoporous silica could be applied in the smart nanovalve system for the controlled delivery of various guest molecules.

Predicting lanthanide boride inverse sandwich tubular molecular rotors with the smallest core–shell structure

Nanoscale ◽  
2019 ◽  
Vol 11 (44) ◽  
pp. 21311-21316 ◽  
Author(s):  
Xiao-Qin Lu ◽  
Qiang Chen ◽  
Xin-Xin Tian ◽  
Yue-Wen Mu ◽  
Hai-Gang Lu ◽  
...  
Keyword(s):  
First Principles ◽  
Shell Structure ◽  
Molecular Rotors ◽  
Core Shell ◽  
Molecular Rotor ◽  
Sandwich Complexes ◽  
Core Shell Structure

Extensive first-principles theory calculations predict the possibility of bi-decker inverse sandwich complexes La2[B18], La2[B18]2−, and La2[B2@B18], with the B2-centered La2[B2@B18] as a tubular molecular rotor possessing the smallest core–shell structure.

scholarly journals The effect of structural heterogeneity upon the microviscosity of ionic liquids

2020 ◽  
Vol 11 (24) ◽  
pp. 6121-6133 ◽  
Author(s):  
Ryan Clark ◽  
Mohd A. Nawawi ◽  
Ana Dobre ◽  
David Pugh ◽  
Qingshan Liu ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Bulk Viscosity ◽  
Structural Heterogeneity ◽  
Molecular Rotors ◽  
Complex Relationship ◽  
Molecular Rotor ◽  
Time Resolved Fluorescence ◽  
Time Resolved

The behaviour of two molecular rotors have been studied in various ionic liquids. Time resolved fluorescence shows a complex relationship between the bulk viscosity of the ionic liquid and microstructure of solvent around each molecular rotor.

Precision Assessment of Biofluid Viscosity Measurements Using Molecular Rotors

2005 ◽  
Vol 127 (3) ◽  
pp. 450-454 ◽  
Author(s):  
Walter J. Akers ◽  
Mark A. Haidekker
Keyword(s):  
Fluorescence Emission ◽  
High Viscosity ◽  
Plasma Viscosity ◽  
Molecular Rotors ◽  
Solution Viscosity ◽  
Human Blood Plasma ◽  
Fluid Viscosity ◽  
Molecular Rotor ◽  
Test Set ◽  
Precision Assessment

Blood viscosity changes with many pathologic conditions, but its importance has not been fully investigated because the current methods of measurement are poorly suited for clinical applications. The use of viscosity-sensitive fluorescent molecular rotors to determine fluid viscosity in a nonmechanical manner has been investigated recently, but it is unknown how the precision of the fluorescence-based method compares to established mechanical viscometry. Human blood plasma viscosity was modulated with high-viscosity plasma expanders, dextran, pentastarch, and hetastarch. The samples were divided into a calibration and a test set. The relationship between fluorescence emission and viscosity was established using the calibration set. Viscosity of the test set was determined by fluorescence and by cone-and-plate viscometer, and the precision of both methods compared. Molecular rotor fluorescence intensity showed a power law relationship with solution viscosity. Mechanical measurements deviated from the theoretical viscosity value by less than 7.6%, while fluorescence-based measurements deviated by less than 6%. The average coefficient of variation was 6.9% (mechanical measurement) and 3.4% to 3.8% (fluorescence-based measurement, depending on the molecular rotor used). Fluorescence-based viscometry exhibits comparable precision to mechanical viscometry. Fluorescence viscometry does not apply shear and is therefore more practical for biofluids which have apparent non-Newtonian properties. In addition, fluorescence instrumentation makes very fast serial measurements possible, thus promising new areas of application in laboratory and clinical settings.

CO2 regulates molecular rotor dynamics in porous materials

2017 ◽  
Vol 53 (55) ◽  
pp. 7776-7779 ◽  
Author(s):  
S. Bracco ◽  
T. Miyano ◽  
M. Negroni ◽  
I. Bassanetti ◽  
L. Marchio' ◽  
...  
Keyword(s):  
Porous Materials ◽  
Molecular Crystals ◽  
Rotor Dynamics ◽  
Molecular Rotors ◽  
Molecular Rotor

Porous molecular crystals contain fast molecular rotors whose dynamics can be controlled by CO2.

A ferroelastic molecular rotor crystal showing inverse temperature symmetry breaking

2021 ◽  
Author(s):  
Le-Ping Miao ◽  
Lin-Lin Chu ◽  
Xiang-Bin Han ◽  
Bei-Dou Liang ◽  
Chao-Yang Chai ◽  
...  
Keyword(s):  
Symmetry Breaking ◽  
Smart Materials ◽  
Molecular Crystals ◽  
Molecular Rotors ◽  
Inverse Temperature ◽  
Next Generation ◽  
Molecular Rotor ◽  
Dynamic Materials ◽  
Typical Type

Functional dynamic molecular crystals have drawn increasing interest in exploring next-generation flexible and smart materials. Molecular rotors, as a typical type of dynamic materials, are good candidates to exhibit bulk...

scholarly journals Push–pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand–receptor interactions

2016 ◽  
Vol 4 (14) ◽  
pp. 3002-3009 ◽  
Author(s):  
Iuliia A. Karpenko ◽  
Yosuke Niko ◽  
Viktor P. Yakubovskyi ◽  
Andriy O. Gerasov ◽  
Dominique Bonnet ◽  
...  
Keyword(s):  
Molecular Rotors ◽  
Live Cells ◽  
Molecular Rotor ◽  
Solvatochromic Dyes ◽  
Fluorogenic Probe ◽  
Receptor Interactions ◽  
Fluorogenic Probes ◽  
Detection Of Biomolecules

Fluorescent solvatochromic dyes and molecular rotors have attracted considerable attention as fluorogenic probes because of background-free detection of biomolecules in live cells in no-wash conditions.

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