A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone
instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering
the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth
factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic
therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management
of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and
growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement
of nanotechnology can ameliorate the performance of these protective coverings. In recent years,
nano-based formulations have gained immense popularity among researchers for the wound healing process due
to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the
entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic
and herbal agents, and combination therapy available for the treatment and the current nano-based systems
available for delivery through the topical route for wound healing.