Star-Shaped Polylactide Dipyridamole Conjugated to 5-Fluorouracil and 4-Piperidinopiperidine Nanocarriers for Bioimaging and Dual Drug Delivery in Cancer Cells

2021 ◽  
Author(s):  
Dhanya Moorkoth ◽  
Kesavan Madhavan Nampoothiri ◽  
Selvaraj Nagarajan ◽  
Aswathy Ravindran Girija ◽  
Sivakumar Balasubramaniyan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Dual Drug

Photosensitizer-Incorporated Quadruplex DNA-Gated Nanovechicles for Light-Triggered, Targeted Dual Drug Delivery to Cancer Cells

Small ◽  
2013 ◽  
Vol 9 (16) ◽  
pp. 2793-2800 ◽  
Author(s):  
Cuie Chen ◽  
Li Zhou ◽  
Jie Geng ◽  
Jinsong Ren ◽  
Xiaogang Qu
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Quadruplex Dna ◽  
Dual Drug

Folic acid-functionalized niosomal nanoparticles for selective dual-drug delivery into breast cancer cells: An in-vitro investigation

2020 ◽  
Vol 31 (9) ◽  
pp. 4064-4071
Author(s):  
Iman Akbarzadeh ◽  
Mohammad Tavakkoli Yaraki ◽  
Saeedeh Ahmadi ◽  
Mohsen Chiani ◽  
Dariush Nourouzian
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
In Vitro Investigation ◽  
Dual Drug

scholarly journals Drug Delivery: Photosensitizer-Incorporated Quadruplex DNA-Gated Nanovechicles for Light-Triggered, Targeted Dual Drug Delivery to Cancer Cells (Small 16/2013)

Small ◽  
2013 ◽  
Vol 9 (16) ◽  
pp. 2653-2653 ◽  
Author(s):  
Cuie Chen ◽  
Li Zhou ◽  
Jie Geng ◽  
Jinsong Ren ◽  
Xiaogang Qu
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Quadruplex Dna ◽  
Dual Drug

scholarly journals Redox-Responsive Tumor Targeted Dual-Drug Loaded Biocompatible Metal-Organic Frameworks for Enhancing Anticancer Cytotoxicity

2020 ◽  
Author(s):  
Chang Liu ◽  
Xiaoyu Xu ◽  
Junnian Zhou ◽  
Jiaqi Yan ◽  
Dongqing Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Cells ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Laser Scanning Microscopy ◽  
Dichloroacetic Acid ◽  
Redox Responsive ◽  
Metal Organic ◽  
Dual Drug

Abstract Metal-organic frameworks (MOFs) have proven to be a promising class of drug carriers due to their high porosity, crystalline properties with defined structure information, and their potential for further functionalization. However, to date, no extensive research has been conducted on MOF-based drug carriers with stimuli-responsive, dual-drug delivery, and tumor targeting functions. Here, we demonstrate the strategy of constructing a redox responsive and tumor-targeted MOF, as dual-drug carrier, by anchoring functional disulfide anhydride and folic acid (FA) molecules to the organic links of MOFs, respectively. The MOF composites show the controlled release of loaded 5-fluorouracil (5-FU) entrapped within UiO-66-NH2 nanostructures modified by dichloroacetic acid (DCA). Moreover, the MOF building block DCA acts as a synergistical drug to 5-FU in cancer cells inhibition. Through disulfide bonds, the gated MOF has redox-responsive drugs release. The confocal laser scanning microscopy further proved that conjugation of folic acid to the MOF surface can significantly enhance the targeting ability to cancer cells and the cancer cell uptake of FA-MOFs. The synthesis of redox-responsive dual-drug delivery MOF hybrids paves the way to assemble of other MOF hybrids that respond to other triggering factors such as light, temperature, pH, or biomarkers. The properties and functions of such materials are expected to influence the development of sensors, new catalysts, photonic devices, and drug delivery carriers.

PTX encapsulated by an XG–DOX conjugate for combination therapy against multi-drug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (109) ◽  
pp. 107606-107612 ◽  
Author(s):  
Zhuli Huang ◽  
Xuan Xie ◽  
Jean Felix Mukerabigwi ◽  
Chang Wang ◽  
Shufang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multi Drug Resistance ◽  
New Type ◽  
Dual Drug

A new type of targeted dual drug delivery system was designed and possesses outstanding advantages over ordinary systems, proving effective against MDR cancer cells.

Dually folate/CD44 receptor-targeted self-assembled hyaluronic acid nanoparticles for dual-drug delivery and combination cancer therapy

2017 ◽  
Vol 5 (33) ◽  
pp. 6835-6846 ◽  
Author(s):  
Liang Song ◽  
Zhou Pan ◽  
Huabing Zhang ◽  
Yanxiu Li ◽  
Yinying Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Anticancer Effect ◽  
Cd44 Receptor ◽  
Dual Targeting ◽  
Combination Cancer Therapy ◽  
Self Assembled ◽  
Dual Drug

Self-assembled methotrexate-hyaluronic acid-octadecylamine nanoparticles loaded with curcumin have dual-targeting and combinational anticancer effect to folate and CD44 receptors overexpressed cancer cells.

The Improvement of Paclitaxel Cytotoxicity using Nanocellulose based Nature Resources

2019 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
R Nahrowi ◽  
A Setiawan ◽  
Noviany Noviany ◽  
I Sukmana ◽  
S D Yuwono
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Natural Resources ◽  
Cell Viability ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Target Cell ◽  
Mitotic Cycle ◽  
Potential Sources ◽  
Local Accumulation

Paclitaxel is one of the cancer drugs that often used. These drug kills cancer cells byinhibiting mitotic cycle. The efficiency of paclitaxel is increased by the use ofnanomaterials as a carrier of paclitaxel. Nanomaterials can enhance encapsulationefficiency, improve the drug release to the target cell following nanomaterialdegradation, and improve local accumulation of drug in the cell through endocytosisreceptor. Nanomaterial that often used forencapsulation of paclitaxel is a polymerderived from natural resources such as cellulose. The advantages of cellulose as acarrier of paclitaxel are nontoxic, biodegradable, and very abundant from varioussources. One of the potential sources of cellulose for drug delivery system is cassavabaggase.Keywords: Paclitaxel, encapsulation, cell viability, nanocellulose

Improved Therapeutic Efficacy of Topotecan Against A549 Lung Cancer Cells with Folate-targeted Topotecan Liposomes

2020 ◽  
Vol 21 (11) ◽  
pp. 902-909
Author(s):  
Jingxin Zhang ◽  
Weiyue Shi ◽  
Gangqiang Xue ◽  
Qiang Ma ◽  
Haixin Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Lung Tumor ◽  
A549 Cells ◽  
Delivery Systems ◽  
Lung Cancer Cells

Background: Among all cancers, lung cancer has high mortality among patients in most of the countries in the world. Targeted delivery of anticancer drugs can significantly reduce the side effects and dramatically improve the effects of the treatment. Folate, a suitable ligand, can be modified to the surface of tumor-selective drug delivery systems because it can selectively bind to the folate receptor, which is highly expressed on the surface of lung tumor cells. Objective: This study aimed to construct a kind of folate-targeted topotecan liposomes for investigating their efficacy and mechanism of action in the treatment of lung cancer in preclinical models. Methods: We conjugated topotecan liposomes with folate, and the liposomes were characterized by particle size, entrapment efficiency, cytotoxicity to A549 cells and in vitro release profile. Technical evaluations were performed on lung cancer A549 cells and xenografted A549 cancer cells in female nude mice, and the pharmacokinetics of the drug were evaluated in female SD rats. Results: The folate-targeted topotecan liposomes were proven to show effectiveness in targeting lung tumors. The anti-tumor effects of these liposomes were demonstrated by the decreased tumor volume and improved therapeutic efficacy. The folate-targeted topotecan liposomes also lengthened the topotecan blood circulation time. Conclusion: The folate-targeted topotecan liposomes are effective drug delivery systems and can be easily modified with folate, enabling the targeted liposomes to deliver topotecan to lung cancer cells and kill them, which could be used as potential carriers for lung chemotherapy.

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