A pH sensitive polymeric micelle for co-delivery of doxorubicin and α-TOS for colon cancer therapy

2017 ◽  
Vol 5 (29) ◽  
pp. 5870-5880 ◽  
Author(s):  
Tilahun Ayane Debele ◽  
Kuan-Yi Lee ◽  
Ning-Yu Hsu ◽  
Yi-Ting Chiang ◽  
Lu-Yi Yu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Drug Release ◽  
Cancer Cells ◽  
Polymeric Micelle ◽  
Ph Sensitive ◽  
Normal Cells

pH-Sensitive rod-like micelles were designed to improve drug release, to increase cytotoxicity towards cancer cells, and to reduce cytotoxicity towards normal cells.

Locked nucleic acid modified bi-specific aptamer-targeted nanoparticles carrying survivin antagonist towards effective colon cancer therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (37) ◽  
pp. 29008-29016 ◽  
Author(s):  
Kislay Roy ◽  
Rupinder K. Kanwar ◽  
Chun Hei Antonio Cheung ◽  
Cassandra Lee Fleming ◽  
Rakesh N. Veedu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Nucleic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Locked Nucleic Acid ◽  
Targeted Nanoparticles ◽  
Target Cancer

EpCAM and nucleolin translocate into the cytoplasm and nucleus that facilitates enhanced uptake of nanocarrier to specifically target cancer cells.

Plasmonic CuS nanodisk assembly based composite nanocapsules for NIR-laser-driven synergistic chemo-photothermal cancer therapy

2018 ◽  
Vol 6 (7) ◽  
pp. 1035-1043 ◽  
Author(s):  
Jian He ◽  
Lisha Ai ◽  
Xin Liu ◽  
Hao Huang ◽  
Yuebin Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Cancer Cells ◽  
Therapeutic Effects ◽  
Release Behavior ◽  
Sustained Drug Release ◽  
Drug Release Behavior ◽  
Nir Laser

The NIR-laser-driven plasmonic photothermal and sustained drug release behavior of CuS–PTX/SiO2 nanocapsules show great synergistic chemo-photothermal therapeutic effects on cancer cells in vitro and in vivo.

scholarly journals Gene interfered-ferroptosis therapy for cancers

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jinliang Gao ◽  
Tao Luo ◽  
Jinke Wang
Keyword(s):  
Drug Resistance ◽  
Cancer Therapy ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Iron Nanoparticles ◽  
Tumor Growth Inhibition ◽  
Specific Gene ◽  
Normal Cells ◽  
Adeno Associated Virus ◽  
Metabolic Genes

AbstractAlthough some effective therapies have been available for cancer, it still poses a great threat to human health and life due to its drug resistance and low response in patients. Here, we develop a ferroptosis-based therapy by combining iron nanoparticles and cancer-specific gene interference. The expression of two iron metabolic genes (FPN and LCN2) was selectively knocked down in cancer cells by Cas13a or microRNA controlled by a NF-κB-specific promoter. Cells were simultaneously treated by iron nanoparticles. As a result, a significant ferroptosis was induced in a wide variety of cancer cells. However, the same treatment had little effect on normal cells. By transferring genes with adeno-associated virus and iron nanoparticles, the significant tumor growth inhibition and durable cure were obtained in mice with the therapy. In this work, we thus show a cancer therapy based on gene interference-enhanced ferroptosis.

scholarly journals 3-Bromopyruvate potentiates TRAIL-induced apoptosis in human colon cancer cells through a reactive oxygen species- and caspase-dependent mitochondrial pathway

2019 ◽  
Vol 97 (12) ◽  
pp. 1176-1184 ◽  
Author(s):  
Hassan Abbaszadeh ◽  
Armita Valizadeh ◽  
Masoud Mahdavinia ◽  
Ali Teimoori ◽  
Mohammad Hassan Pipelzadeh ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Human Colon ◽  
Inhibitory Effect ◽  
Oxygen Species ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Normal Cells

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a promising anticancer cytokine with minimal toxicity towards normal cells. Nevertheless, most primary cancers are often intrinsically TRAIL-resistant or can acquire resistance after TRAIL therapy. This study aimed to investigate the inhibitory effect of co-treatment of 3-bromopyruvate (3-BP) as a potent anticancer agent with TRAIL on colon cancer cells (HT-29). The results of present study indicated that combined treatment with 3-BP and TRAIL inhibited the proliferation of HT-29 cells to a greater extent (88.4%) compared with 3-BP (54%) or TRAIL (11%) treatment alone. In contrast, the combination of 3-BP and TRAIL had no significant inhibitory effect on the proliferation of normal cells (HEK-293) (8.4%). At a cellular mechanistic level, the present study showed that 3-BP sensitized human colon cancer cells to TRAIL-induced apoptosis via reactive oxygen species generation, upregulation of Bax, downregulation of Bcl-2 and survivin, release of cytochrome c into the cytosol, and activation of caspase-3. In normal cells, 3-BP, TRAIL, or combination of both had no significant effect on the reactive oxygen species levels, release of cytochrome c, and caspase-3 activity. Therefore, the combination of 3-BP and TRAIL can be a promising therapeutic strategy for treatment of colon cancer.

Nanocarriers with multi-locked DNA valves targeting intracellular tumor-related mRNAs for controlled drug release

Nanoscale ◽  
2017 ◽  
Vol 9 (44) ◽  
pp. 17318-17324 ◽  
Author(s):  
Yanhua Li ◽  
Yuanyuan Chen ◽  
Wei Pan ◽  
Zhengze Yu ◽  
Limin Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Cells ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Normal Cells ◽  
Tremendous Challenge

The fabrication of well-behaved drug delivery systems that can transport drugs to specifically treat cancer cells rather than normal cells is still a tremendous challenge.

Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation

2014 ◽  
Vol 5 (8) ◽  
pp. 1909-1914 ◽  
Author(s):  
Lijuan Sun ◽  
Cheng Luo ◽  
Jiankang Liu
Keyword(s):  
Oxidative Stress ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Ros Generation ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Normal Cells ◽  
Human Colon Cancer Cells

Cancer cells are usually under higher levels of oxidative stress compared to normal cells.

scholarly journals Cancer cells have distinct electrical properties that predict a susceptibility to lipophilic anions; a new cancer drug paradigm

2015 ◽  
Author(s):  
Michael D. Forrest
Keyword(s):  
Experimental Data ◽  
Electrical Properties ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Lethal Dose ◽  
Cancer Drug ◽  
Nernst Equation ◽  
Normal Cells ◽  
Lipophilic Anion ◽  
Safe Dose

ABSTRACTI use the Nernst equation, parameterised with experimental data, to predict that cancer cells will accumulate more of a lipophilic anion than normal cells. This effect is correlated to charge number. Model cancer cells accumulate *100 more of an anion, *103 more di-anion, *106 more tri-anion, *108 more tetra-anion and *1010 more penta-anion (>>1 billion times more). The trend endures, conveying even greater specificity, for higher charge numbers. This effect could be leveraged for cancer therapy. Wherein the lipophilic anion is a toxin that targets some vital cellular process, which normal and cancer cells may even share. It delivers a high, lethal dose to cancer cells but a low, safe dose to normal cells. This mathematical finding conveys the prospect of a broad, powerful new front against cancer.

scholarly journals The Potential of MiRNAs as Biomarkers and Therapy Targets for Cancer

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Teresa L. Wargasetia
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Prognostic Biomarker ◽  
Cancer Development ◽  
Mirna Biogenesis ◽  
Diagnostic Biomarker ◽  
Normal Cells ◽  
Therapy Targets ◽  
A Cell ◽  
Cellular Pathways

MicroRNAs (miRNAs) are involved in the signaling circuits regulation within a cell andtheir deregulation plays an important role in cancer development and progression. In thisreview, we discussed miRNA biogenesis, miRNA function and the effect of miRNA abnormalitiesin cellular pathways that led to transformation of normal cells into cancer cells, as well as theindication of miRNAs as diagnostic and prognostic biomarkers of various types of cancer, asbiomarkers to predict the response to cancer therapy and the potential for development ofmiRNAs as cancer targeted therapy.Keywords: miRNA, cancer, diagnostic biomarker, prognostic biomarker, cancer therapy

scholarly journals A novel pH-sensitive liposome to trigger delivery of afatinib to cancer cells: Impact on lung cancer therapy

2018 ◽  
Vol 259 ◽  
pp. 154-166 ◽  
Author(s):  
Alanood S. Almurshedi ◽  
Mahasen Radwan ◽  
Samia Omar ◽  
Ayodele A. Alaiya ◽  
Mohamed M. Badran ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Ph Sensitive ◽  
Lung Cancer Therapy

Transferrin receptor-targeted redox/pH-sensitive podophyllotoxin prodrug micelles for multidrug-resistant breast cancer therapy

2019 ◽  
Vol 7 (38) ◽  
pp. 5814-5824 ◽  
Author(s):  
Yongfei Li ◽  
Mie Chen ◽  
Bowen Yao ◽  
Xun Lu ◽  
Xiaoqing Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Transferrin Receptor ◽  
Multidrug Resistant ◽  
Ph Sensitive ◽  
Breast Cancer Therapy ◽  
Glycoprotein P ◽  
P Glycoprotein

Podophyllotoxin (PPT), a toxic polyphenol extracted from the roots of Podophyllum species, showed remarkable activity against P-glycoprotein (P-gp) mediated multidrug resistant (MDR) cancer cells.

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