Transferrin receptor-targeted redox/pH-sensitive podophyllotoxin prodrug micelles for multidrug-resistant breast cancer therapy

2019 ◽  
Vol 7 (38) ◽  
pp. 5814-5824 ◽  
Author(s):  
Yongfei Li ◽  
Mie Chen ◽  
Bowen Yao ◽  
Xun Lu ◽  
Xiaoqing Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Transferrin Receptor ◽  
Multidrug Resistant ◽  
Ph Sensitive ◽  
Breast Cancer Therapy ◽  
Glycoprotein P ◽  
P Glycoprotein

Podophyllotoxin (PPT), a toxic polyphenol extracted from the roots of Podophyllum species, showed remarkable activity against P-glycoprotein (P-gp) mediated multidrug resistant (MDR) cancer cells.

Co-delivery of doxorubicin and the traditional Chinese medicine quercetin using biotin–PEG2000–DSPE modified liposomes for the treatment of multidrug resistant breast cancer

RSC Advances ◽  
2016 ◽  
Vol 6 (114) ◽  
pp. 113173-113184 ◽  
Author(s):  
Jiulong Zhang ◽  
Yue Luo ◽  
Xiufeng Zhao ◽  
Xiaowei Li ◽  
Kexin Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Chinese Medicine ◽  
Cancer Therapy ◽  
Traditional Chinese Medicine ◽  
Efflux Pump ◽  
Multidrug Resistant ◽  
Glycoprotein P ◽  
P Glycoprotein

At present, multidrug resistance (MDR) in cancer therapy is an international problem, which is caused mostly by the overexpressed P-glycoprotein (P-gp) efflux pump.

scholarly journals pH-Sensitive Poly(β-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 952 ◽  
Author(s):  
Mengxue Zhou ◽  
Xingcai Zhang ◽  
Jin Xie ◽  
Rongxiang Qi ◽  
Huiru Lu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Ph Sensitive ◽  
Amino Ester ◽  
Stimuli Responsive ◽  
Glycoprotein P ◽  
Cell Internalization ◽  
Promising Tool ◽  
Intracellular Drug Delivery ◽  
Mcf 7

Multidrug resistance (MDR) remains an unmet challenge in chemotherapy. Stimuli-responsive nanocarriers emerge as a promising tool to overcome MDR. Herein, pH-sensitive poly(β-amino ester)s polymers (PHP)-based micellar nanoparticles were synthesized for enhanced doxorubicin (DOX) delivery in drug resistant breast cancer MCF-7/ADR cells. DOX-loaded PHP micelles showed rapid cell-internalization and lysosomal escape in MCF-7/ADR cells. The cytotoxicity assays showed relatively higher cell inhibition of DOX-loaded PHP micelles than that of free DOX against MCF-7/ADR cells. Further mechanistic studies showed that PHP micelles were able to inhibit P-glycoprotein (P-gp) activity by lowering mitochondrial membrane potentials and ATP levels. These results suggested that the enhanced antitumor effect might be attributed to PHP-mediated lysosomal escape and drug efflux inhibition. Therefore, PHP would be a promising pH-responsive nanocarrier for enhanced intracellular drug delivery and overcoming MDR in cancer cells.

scholarly journals Co-delivery of dihydroartemisinin and docetaxel in pH-sensitive nanoparticles for treating metastatic breast cancerviathe NF-κB/MMP-2 signal pathway

RSC Advances ◽  
2018 ◽  
Vol 8 (39) ◽  
pp. 21735-21744 ◽  
Author(s):  
Jin Tao ◽  
Zeng Tan ◽  
Lu Diao ◽  
Zhonghua Ji ◽  
Jiahuan Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cancer Therapy ◽  
Synergistic Effects ◽  
Metastatic Breast ◽  
Signal Pathway ◽  
Ph Sensitive ◽  
Breast Cancer Therapy

Co-delivery DTX and DHA as acid-sensitive nanoparticles to exert synergistic effects for metastatic breast cancer therapy.

Estrogen-Anchored pH-Sensitive Liposomes as Nanomodule Designed for Site-Specific Delivery of Doxorubicin in Breast Cancer Therapy

2011 ◽  
Vol 9 (1) ◽  
pp. 176-186 ◽  
Author(s):  
Shivani R. Paliwal ◽  
Rishi Paliwal ◽  
Harish C. Pal ◽  
Ajeet K. Saxena ◽  
Pradyumana R. Sharma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Ph Sensitive ◽  
Breast Cancer Therapy ◽  
Site Specific

Nature of the charged head group dictates the anticancer potential of lithocholic acid-tamoxifen conjugates for breast cancer therapy

MedChemComm ◽  
2015 ◽  
Vol 6 (5) ◽  
pp. 778-787 ◽  
Author(s):  
Kavita Yadav ◽  
Priyanshu Bhargava ◽  
Sandhya Bansal ◽  
Manish Singh ◽  
Siddhi Gupta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Breast Cancer Cells ◽  
Lithocholic Acid ◽  
Head Group ◽  
Breast Cancer Therapy

Anticancer drug Tamoxifen is modified to charged lithocholic acid derived amphiphile for enhanced cytotoxicity against breast cancer cells.

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