Alkylated branched poly(β-amino esters) demonstrate strong DNA encapsulation, high nanoparticle stability and robust gene transfection efficacy

2017 ◽  
Vol 5 (27) ◽  
pp. 5307-5310 ◽  
Author(s):  
Shuai Liu ◽  
Zhibing Sun ◽  
Dezhong Zhou ◽  
Tianying Guo
Keyword(s):  
Dna Binding ◽  
Cellular Uptake ◽  
Gene Transfection ◽  
Nanoparticle Stability ◽  
Amino Esters ◽  
Transfection Efficacy ◽  
Dna Encapsulation

Branching leads to alkylated poly(β-amino esters) with stronger DNA binding, higher nanoparticle stability, higher cellular uptake and better gene transfection performance.

scholarly journals Cellular Uptake, DNA Binding and Apoptosis Induction of Cytotoxic Trans-[PtCl2(N,N-dimethylamine)(Isopropylamine)] in A2780cisR Ovarian Tumor Cells

2001 ◽  
Vol 8 (1) ◽  
pp. 29-37 ◽  
Author(s):  
José M. Pérez ◽  
Eva I. Montero ◽  
Adoración G. Quiroga ◽  
Miguel A Fuertes ◽  
Carlos Alonso ◽  
...  
Keyword(s):  
Dna Binding ◽  
Cytotoxic Activity ◽  
Cellular Uptake ◽  
Cell Biology ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
Platinum Compound ◽  
X Ray ◽  
Molecular Cell Biology ◽  
Ovarian Tumor Cells

Trans-[PtCl2(N,N-dimethylamine)(isopropylamine)] is a novel trans-platinum compound that shows cytotoxic activity in several cisplatin resistant cell lines. The aim of this paper was to analyse, by means of molecular cell biology techniques and total reflection X-ray fluorescence (TXRF), the cytotoxic activity, the induction of apoptosis, the cellular uptake and the DNA binding of trans-[PtCl2(N,N-dimethylamine)(isopropylamine)] in the cisplatin resistant cell line A2780cisR. The results show that this drug is more cytotoxic and induces a higher amount of apoptotic cells than cisplatin in A2780cisR cells. However, the intracellular accumulation and extent of binding to DNA of trans-[PtCl2(N,N-dimethylamine)( isopropylamine)] is lower than that of cis-DDP. Moreover, trans-[PtCl2(N,N-dimethylamine)(isopropylaminae)] is partially inactivated by intracellular levels of glulathione. The result suggest that circumvention of ciplatin resistance by trans-[PtCl2(N,N-dimethylamine)(isopropylamine)] in A2780cisR cells might be related with the ability of this drug to induce apoptosis.

Ruthenium(II) Polypyridyl Complexes: Synthesis and Studies of DNA Binding, Photocleavage, Cytotoxicity, Apoptosis, Cellular Uptake, and Antioxidant Activity

2011 ◽  
Vol 30 (10) ◽  
pp. 829-838 ◽  
Author(s):  
Yun-Jun Liu ◽  
Zhen-Hua Liang ◽  
Zheng-Zheng Li ◽  
Jun-Hua Yao ◽  
Hong-Liang Huang
Keyword(s):  
Antioxidant Activity ◽  
Dna Binding ◽  
Cellular Uptake ◽  
Polypyridyl Complexes

scholarly journals In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains

2012 ◽  
Vol 7 (7) ◽  
pp. 1276-1280 ◽  
Author(s):  
Mateo I. Sánchez ◽  
José Martínez-Costas ◽  
Francisco Gonzalez ◽  
María A. Bermudez ◽  
M. Eugenio Vázquez ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Cellular Uptake

Cytotoxicity of anthracyclines: Correlation with cellular uptake, intracellular distribution and DNA binding

1994 ◽  
Vol 69 (1) ◽  
pp. S13-S17 ◽  
Author(s):  
F. Gieseler ◽  
H. Biersack ◽  
T. Brieden ◽  
J. Manderscheid ◽  
V. Nüßler
Keyword(s):  
Dna Binding ◽  
Cellular Uptake ◽  
Intracellular Distribution
Sign in / Sign up

Export Citation Format

Share Document