Cytotoxicity of anthracyclines: Correlation with cellular uptake, intracellular distribution and DNA binding

1994 ◽  
Vol 69 (1) ◽  
pp. S13-S17 ◽  
Author(s):  
F. Gieseler ◽  
H. Biersack ◽  
T. Brieden ◽  
J. Manderscheid ◽  
V. Nüßler
Keyword(s):  
Dna Binding ◽  
Cellular Uptake ◽  
Intracellular Distribution

scholarly journals Cellular Uptake, DNA Binding and Apoptosis Induction of Cytotoxic Trans-[PtCl2(N,N-dimethylamine)(Isopropylamine)] in A2780cisR Ovarian Tumor Cells

2001 ◽  
Vol 8 (1) ◽  
pp. 29-37 ◽  
Author(s):  
José M. Pérez ◽  
Eva I. Montero ◽  
Adoración G. Quiroga ◽  
Miguel A Fuertes ◽  
Carlos Alonso ◽  
...  
Keyword(s):  
Dna Binding ◽  
Cytotoxic Activity ◽  
Cellular Uptake ◽  
Cell Biology ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
Platinum Compound ◽  
X Ray ◽  
Molecular Cell Biology ◽  
Ovarian Tumor Cells

Trans-[PtCl2(N,N-dimethylamine)(isopropylamine)] is a novel trans-platinum compound that shows cytotoxic activity in several cisplatin resistant cell lines. The aim of this paper was to analyse, by means of molecular cell biology techniques and total reflection X-ray fluorescence (TXRF), the cytotoxic activity, the induction of apoptosis, the cellular uptake and the DNA binding of trans-[PtCl2(N,N-dimethylamine)(isopropylamine)] in the cisplatin resistant cell line A2780cisR. The results show that this drug is more cytotoxic and induces a higher amount of apoptotic cells than cisplatin in A2780cisR cells. However, the intracellular accumulation and extent of binding to DNA of trans-[PtCl2(N,N-dimethylamine)( isopropylamine)] is lower than that of cis-DDP. Moreover, trans-[PtCl2(N,N-dimethylamine)(isopropylaminae)] is partially inactivated by intracellular levels of glulathione. The result suggest that circumvention of ciplatin resistance by trans-[PtCl2(N,N-dimethylamine)(isopropylamine)] in A2780cisR cells might be related with the ability of this drug to induce apoptosis.

Ruthenium(II) Polypyridyl Complexes: Synthesis and Studies of DNA Binding, Photocleavage, Cytotoxicity, Apoptosis, Cellular Uptake, and Antioxidant Activity

2011 ◽  
Vol 30 (10) ◽  
pp. 829-838 ◽  
Author(s):  
Yun-Jun Liu ◽  
Zhen-Hua Liang ◽  
Zheng-Zheng Li ◽  
Jun-Hua Yao ◽  
Hong-Liang Huang
Keyword(s):  
Antioxidant Activity ◽  
Dna Binding ◽  
Cellular Uptake ◽  
Polypyridyl Complexes

scholarly journals In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains

2012 ◽  
Vol 7 (7) ◽  
pp. 1276-1280 ◽  
Author(s):  
Mateo I. Sánchez ◽  
José Martínez-Costas ◽  
Francisco Gonzalez ◽  
María A. Bermudez ◽  
M. Eugenio Vázquez ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Cellular Uptake

Interaction with culture medium components, cellular uptake and intracellular distribution of cobalt nanoparticles, microparticles and ions in Balb/3T3 mouse fibroblasts

2012 ◽  
Vol 8 (1) ◽  
pp. 88-99 ◽  
Author(s):  
Enrico Sabbioni ◽  
Salvador Fortaner ◽  
Massimo Farina ◽  
Riccardo Del Torchio ◽  
Claudia Petrarca ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Culture Medium ◽  
Cobalt Nanoparticles ◽  
Intracellular Distribution ◽  
Mouse Fibroblasts ◽  
Medium Components

scholarly journals Gold Nanoparticle Size and Shape Effects on Cellular Uptake and Intracellular Distribution of siRNA Nanoconstructs

2017 ◽  
Vol 28 (6) ◽  
pp. 1791-1800 ◽  
Author(s):  
Jun Yue ◽  
Timothy Joel Feliciano ◽  
Wenlong Li ◽  
Andrew Lee ◽  
Teri W. Odom
Keyword(s):  
Gold Nanoparticle ◽  
Cellular Uptake ◽  
Intracellular Distribution ◽  
Nanoparticle Size ◽  
Size And Shape ◽  
Shape Effects

scholarly journals Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule

2020 ◽  
Author(s):  
Timothy Kench ◽  
Peter A. Summers ◽  
Marina K. Kuimova ◽  
James Lewis ◽  
Ramon Vilar
Keyword(s):  
Dna Binding ◽  
Cellular Uptake ◽  
Small Molecule ◽  
Dna Interactions ◽  
Cellular Localisation ◽  
Unique Approach

In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a stopper that can be cleaved by either light or the activity of an enzyme.

Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent

2014 ◽  
Vol 74 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Ying Yi Chen ◽  
Pradeep B. Lukka ◽  
Wayne R. Joseph ◽  
Graeme J. Finlay ◽  
James W. Paxton ◽  
...  
Keyword(s):  
Dna Binding ◽  
Cellular Uptake ◽  
Topoisomerase Ii ◽  
Antitumor Agent
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