scholarly journals A statherin-derived peptide promotes hydroxyapatite crystallization and in situ remineralization of artificial enamel caries

RSC Advances ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 1647-1655 ◽  
Author(s):  
Kun Wang ◽  
Xiuqing Wang ◽  
Haoran Li ◽  
Sainan Zheng ◽  
Qian Ren ◽  
...  
Keyword(s):  
Dental Caries ◽  
Tooth Enamel ◽  
Enamel Surface ◽  
Enamel Caries

A novel biomimetic peptide inspired by salivary statherin was developed and exhibited beneficial potentials in promoting remineralization of hydroxyapatite on tooth enamel surface, providing a desirable alternative restorative strategy against dental caries.

scholarly journals Effect of Hydrogen Peroxide at 35% on the Morphology of Enamel and Interference in the De-remineralization Process: An In Situ Study

2012 ◽  
Vol 37 (5) ◽  
pp. 518-525 ◽  
Author(s):  
AM de Arruda ◽  
PH dos Santos ◽  
RH Sundfeld ◽  
SB Berger ◽  
ALF Briso
Keyword(s):  
Hydrogen Peroxide ◽  
Dental Caries ◽  
Microscopic Analysis ◽  
Enamel Surface ◽  
In Situ Study ◽  
Bovine Enamel ◽  
Histologic Changes

SUMMARY This study evaluated the microhardness and histomorphology of bovine enamel when 35% hydrogen peroxide is used. A total of 44 specimens were adapted to removable devices used by 11 individuals subjected to dental caries challenge. A decrease in microhardness was observed for all groups after the cariogenic challenge. Microscopic analysis revealed that fragments subjected to cariogenic challenge associated with bleaching had more intense superficial histologic changes, but the depth of the lesions remained unchanged. It was concluded that 35% hydrogen peroxide enhanced the reduction in hardness and histomorphologic changes in the enamel surface exposed to cariogenic challenge.

Effective in situ repair and bacteriostatic material of tooth enamel based on salivary acquired pellicle inspired oligomeric procyanidins

2016 ◽  
Vol 7 (44) ◽  
pp. 6761-6769 ◽  
Author(s):  
Shuhui Zhang ◽  
Libang He ◽  
Yinxin Yang ◽  
Bo Yang ◽  
Yixue Liao ◽  
...  
Keyword(s):  
Dental Caries ◽  
Tooth Enamel ◽  
Tooth Surface ◽  
Cariogenic Bacteria ◽  
In Situ Repair

Remineralization and reduction of cariogenic bacteria at the tooth surface are effective ways to treat dental caries.

scholarly journals Biofilm three-dimensional architecture influences in situ pH distribution pattern on the human enamel surface

2017 ◽  
Vol 9 (2) ◽  
pp. 74-79 ◽  
Author(s):  
Jin Xiao ◽  
Anderson T Hara ◽  
Dongyeop Kim ◽  
Domenick T Zero ◽  
Hyun Koo ◽  
...  
Keyword(s):  
Distribution Pattern ◽  
Three Dimensional ◽  
Enamel Surface ◽  
Ph Distribution ◽  
Human Enamel

The Relationship between Dental Caries and Tooth Enamel Fluoride

1985 ◽  
Vol 19 (5) ◽  
pp. 385-389 ◽  
Author(s):  
J.R. Mellberg ◽  
L.W. Ripa ◽  
G.S. Leske ◽  
M. Sanchez ◽  
R. Polanski
Keyword(s):  
Dental Caries ◽  
Tooth Enamel ◽  
The Relationship

An in sita Model for Simultaneous Assessment of Inhibition of Demineralization and Enhancement of Remineralization

1992 ◽  
Vol 71 (3_suppl) ◽  
pp. 804-810 ◽  
Author(s):  
J.D.B. Featherstone ◽  
D.T. Zero
Keyword(s):  
Tooth Enamel ◽  
Dental Health ◽  
Oral Care ◽  
Protective Effects ◽  
Cross Sectional ◽  
Food Component ◽  
Whole Saliva ◽  
Salivary Function

In situ models to assess the ability of oral care products or food components to enhance remineralization and/or inhibit demineralization of tooth enamel or roots must be very carefully designed to minimize the confounding effects of the many variables involved. Controlling these variables as closely as possible is essential if meaningful answers are to be obtained from the models. We have developed an in situ model which combines the experience of several groups. Detailed screening of subjects is essential. Selection criteria should include good general health, good dental health, mandibular partial denture, at least eight natural teeth, no active caries lesions, known fluoride history, normal salivary function, and no medications that affect salivary function. Each subject carries a sound enamel slab and an enamel slab with a pre-formed caries-like lesion (demineralized in vitro) in his/her denture on each side of the mouth for test periods of two or four weeks. The demineralization challenge is controlled by extra-oral immersion of the appliances in sucrose daily. Daily product exposure or daily food component exposure is used as desired. Compliance indicators and a diet diary are included. Whole saliva flow rate (unstimulated), plaque acidogenicity, and salivary fluoride are monitored during the test periods. At the end of the test period, the test slabs are assessed for mineral change, after being sectioned, by means of cross-sectional microhardness or microradiography. The mineral loss or gain (ΔM, μm × vol%), compared with adjacent control sections retained in the lab, is calculated as change in ΔZ (μm × vol%), namely, ΔM = ΔZTEST - ΔZ.CONTROL. In this model, demineralization occurs in sound enamel and in the pre-formed lesions in the absence of fluoride or other protective agents. The model has the potential to be able to differentiate among fluoride delivery systems and to assess the caries-protective effects of agents other than fluoride by use of small groups of subjects.

scholarly journals Antibiofilm Activity of Mangosteen (Garcinia mangostana L.) Flavonoids against Streptococcus mutans Bacteria

2020 ◽  
Vol 10 (2) ◽  
pp. 48
Author(s):  
Sri Kunarti ◽  
Aulia Ramadhani ◽  
Laskmiari Setyowati
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Tooth Enamel ◽  
Tooth Surface ◽  
Control Group ◽  
Antibiofilm Activity ◽  
Garcinia Mangostana ◽  
Control Group Design ◽  
Biofilm Inhibition ◽  
Significant Difference

Background: Dental caries is one of the most common infectious diseases and often occurs in the community caused by bacteria. Attached bacteria in the tooth surface for a long time will form a biofilm and will lead to demineralization characterized by damage in the structure of the tooth enamel. The bacteria that cause dental caries and can form biofilms is Streptococcus mutans. The bacteria inside biofilms are more resistant to antibacterial agents. Flavonoids in mangosteen pericarp extract can be a cleaner alternative for the anti-biofilm cavity that has properties against Streptococcus mutans. Purpose: To determine the activity of flavonoids in mangosteen pericarp extract at a certain concentration against Streptococcus mutans bacteria. Methods: This study was a laboratory experimental study with a post-test only control group design. Streptococcus mutans were diluted according to the Mc Farland dilution standard 106 in Tryptic Soy Broth (TSB) medium and put in a flexible U-bottom microtiter plate. Then it was incubated for 5x24 hours and checked using crystal violet simple staining to see the formation of biofilms. Flavonoid extract of mangosteen pericarp performed serial dilution in a concentration of 100%, 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, and 0.78% was added, and the incubation process were conducted for 1x24 hours. OD (Optical Density) readings were done with a wavelength of 595 nm. Results: There was a significant difference between the test groups and the positive control group. The concentration of 100% had the anti-biofilm activity and showed the value of the highest percentage of inhibition, whilst the concentration of 0.78% showed a minimum biofilm inhibition concentration. The results were demonstrated by a statistical analysis test. Conclusion: Flavonoid extract of mangosteen pericarp at a certain concentration has anti-biofilm activity against Streptococcus mutans biofilm.

Hydroxyapatite-anchored dendrimer for in situ remineralization of human tooth enamel

Biomaterials ◽  
2013 ◽  
Vol 34 (21) ◽  
pp. 5036-5047 ◽  
Author(s):  
Duo Wu ◽  
Jiaojiao Yang ◽  
Jiyao Li ◽  
Liang Chen ◽  
Bei Tang ◽  
...  
Keyword(s):  
Tooth Enamel ◽  
Human Tooth ◽  
Human Tooth Enamel

scholarly journals Remineralization of enamel caries by an amelogenin-derived peptide and fluoride in vitro

2020 ◽  
Vol 7 (3) ◽  
pp. 283-292 ◽  
Author(s):  
Longjiang Ding ◽  
Sili Han ◽  
Kun Wang ◽  
Sainan Zheng ◽  
Wenyue Zheng ◽  
...  
Keyword(s):  
Tooth Enamel ◽  
The Novel ◽  
Oral Diseases ◽  
Surface Microhardness ◽  
Enamel Caries ◽  
Low Concentrations ◽  
The World ◽  
Mineral Loss ◽  
Hydroxyapatite Crystals

Abstract Dental caries is one of the most common oral diseases in the world. This study was tantamount to investigate the combinatory effects of an amelogenin-derived peptide (called QP5) and fluoride on the remineralization of artificial enamel caries. The peptide QP5 was synthesized and characterized, and the binding capability of the peptide on hydroxyapatite (HA) and demineralized tooth enamel surface was analysed. Then, the mineralization function of the peptide and fluoride was studied through the spontaneous mineralization testing and remineralization on enamel caries in vitro. First, the novel peptide QP5 could bind on the hydroxyapatite and demineralized tooth enamel surfaces. Second, QP5 can transitorily stabilize the formation of amorphous calcium phosphate and direct the transformation into hydroxyapatite crystals alone and in combination with fluoride. In addition, compared to blocks treated by peptide QP5 alone or fluoride, the sample blocks showed significantly higher surface microhardness, lower mineral loss and shallower lesion depth after treatment with a combination of QP5 and fluoride at high or low concentrations. The peptide QP5 could control the crystallization of hydroxyapatite, and combinatory application of peptide QP5 and fluoride had a potential synergistic effect on the remineralization of enamel caries.

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