Rapid construction of complex tetracyclic frameworks via a gold(i)-catalyzed tandem 1,2-acyloxy migration/[3 + 2] cycloaddition/Friedel–Crafts type cyclization reaction of linear enynyl esters

2017 ◽  
Vol 4 (11) ◽  
pp. 2109-2113 ◽  
Author(s):  
Haiyu Sun ◽  
Shiyan Xu ◽  
Zhimin Xing ◽  
Lin Liu ◽  
Shangbiao Feng ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Quaternary Centers ◽  
Rapid Construction ◽  
One Step

Magic “Au”: 3 rings and 2–3 quaternary centers were constructed in one step!

Enantioselective synthesis of chiral 3-alkyl-3-nitro-4-chromanones via chiral thiourea-catalysed intramolecular Michael-type cyclization

2021 ◽  
Author(s):  
Huiqing Chen ◽  
Jie Tang ◽  
Ting Liu ◽  
Li-Fang Yu ◽  
Dong Xing ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Cyclization Reaction ◽  
Rapid Construction

Herein we report an enantioselective method for the rapid construction of chiral 3-nitro-4-chromanones via a chiral thiourea-catalyzed intramolecular Michael-type cyclization reaction. With this method, a series of 3,3-disubstituted-3-nitro-4-chromanones bearing contiguous...

Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A

2017 ◽  
Vol 4 (11) ◽  
pp. 2211-2215 ◽  
Author(s):  
Hao Zhang ◽  
Shiqiang Ma ◽  
Zhimin Xing ◽  
Lin Liu ◽  
Bowen Fang ◽  
...  
Keyword(s):  
Natural Products ◽  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Rapid Construction

A tandem radical cyclization towards the 6/6/5 tricyclic skeleton, which exists in numerous natural products, was developed in modest to good yields.

One-Step Synthesis of Tetrazolo[1,5-a]pyrimidines by Cyclization Reaction of Dihydropyrimidine-2-thiones with Sodium Azide

Heterocycles ◽  
2011 ◽  
Vol 83 (12) ◽  
pp. 2811 ◽  
Author(s):  
Xi-Cun Wang ◽  
Ying Wei ◽  
Yu-Xia Da ◽  
Zhang Zhang ◽  
Zheng-Jun Quan
Keyword(s):  
Sodium Azide ◽  
Cyclization Reaction ◽  
One Step

Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three consecutive stereocenters

Tetrahedron ◽  
2014 ◽  
Vol 70 (10) ◽  
pp. 1895-1902 ◽  
Author(s):  
Bao-Dong Cui ◽  
Shi-Wu Li ◽  
Jian Zuo ◽  
Zhi-Jun Wu ◽  
Xiao-Mei Zhang ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Quaternary Centers

Copper-catalyzed double cyclization reaction of azidoquinones: one-step synthesis of dihydropyrroloindoloquinones and related quinolinoquinones

1987 ◽  
Vol 52 (18) ◽  
pp. 3956-3967 ◽  
Author(s):  
Yoshinori Naruta ◽  
Naoshi Nagai ◽  
Yoshihiro Arita ◽  
Kazuhiro Maruyama
Keyword(s):  
Cyclization Reaction ◽  
One Step

scholarly journals Rapid Construction of a Replication-Competent Infectious Clone of Human Adenovirus Type 14 by Gibson Assembly

Viruses ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 568 ◽  
Author(s):  
Haibin Pan ◽  
Yuqian Yan ◽  
Jing Zhang ◽  
Shan Zhao ◽  
Liqiang Feng ◽  
...  
Keyword(s):  
Infectious Clone ◽  
A549 Cells ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
Enzyme Analysis ◽  
Gibson Assembly ◽  
Assembly Method ◽  
Rapid Construction ◽  
One Step ◽  
Genomic Variant

In 1955, Human adenovirus type 14 (HAdV-B14p) was firstly identified in a military trainee diagnosed as acute respiratory disease (ARD) in the Netherlands. Fifty years later, a genomic variant, HAdV-B14p1, re-emerged in the U.S. and caused large and fatal ARD outbreaks. Subsequently, more and more ARD outbreaks occurred in Canada, the UK, Ireland, and China, in both military and civil settings. To generate a tool for the efficient characterization of this new genomic variant, a full-length infectious genomic clone of HAdV-B14 was successfully constructed using one-step Gibson Assembly method in this study. Firstly, the full genome of HAdV-B14p1 strain GZ01, the first HAdV-B14 isolate in China, was assembled into pBR322 plasmid by Gibson Assembly. The pBRAdV14 plasmid, generated by Gibson Assembly, was analyzed and verified by PCR, restriction enzymes digestion and the sequencing. Secondly, viruses were rescued from pBRAdV14-transfected A549 cells. The integrity of the rescued viruses was identified by restriction enzyme analysis. The complete sequence of the infectious clone was further sequenced. No mutation was found in the infectious clone during the construction when compared with the parental virus and pBR322 sequences. The direct immunofluorescence assay indicated the expression of the hexon protein. Finally, typical virions were observed; the one-step growth curves further showed that the DNA replication and viral reproduction efficiency of pBRAd14 derived viruses was similar with that of wild-type HAdV-B14 strain. The successful construction of the replication-competent infectious clone of pBRAdV14 facilitates the development of vaccine and antiviral drugs against HAdV-B14, as well as provides a novel strategy for rapid construction of infectious viral clones for other large-genome DNA viruses.

Catalyst-free cyclization of anthranils and cyclic amines: one-step synthesis of rutaecarpine

2019 ◽  
Vol 55 (80) ◽  
pp. 12072-12075 ◽  
Author(s):  
Jian Li ◽  
Zheng-Bing Wang ◽  
Yue Xu ◽  
Xue-Chen Lu ◽  
Shang-Rong Zhu ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Efficient Synthesis ◽  
Cyclic Amines ◽  
Catalyst Free ◽  
One Step

An efficient synthesis of rutaecarpine derivatives via a catalyst-free and atom-efficiency cyclization reaction between commercially available anthranils and cyclic amines is described.

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