Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A

2017 ◽  
Vol 4 (11) ◽  
pp. 2211-2215 ◽  
Author(s):  
Hao Zhang ◽  
Shiqiang Ma ◽  
Zhimin Xing ◽  
Lin Liu ◽  
Bowen Fang ◽  
...  
Keyword(s):  
Natural Products ◽  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Rapid Construction

A tandem radical cyclization towards the 6/6/5 tricyclic skeleton, which exists in numerous natural products, was developed in modest to good yields.

Oxacycle synthesis via radical cyclization of β-alkoxyacrylates

2005 ◽  
Vol 77 (12) ◽  
pp. 2073-2081 ◽  
Author(s):  
Eun Lee
Keyword(s):  
Natural Products ◽  
Radical Cyclization ◽  
Cyclization Reaction

Oxolane and oxane units in oxacyclic natural products were prepared via radical cyclization reaction of β-alkoxyacrylates, β-alkoxymethacrylates, and β-alkoxyvinyl ketones.

Regioselective Synthesis of 2,3‐Dihydrobenzo[ f ]isoindolones via Ag‐Catalyzed Sequential Ugi 4CR/Cascade Radical Cyclization Reaction

2021 ◽  
Vol 363 (4) ◽  
pp. 1038-1043
Author(s):  
Ying‐Chun He ◽  
Yan‐Mei Yan ◽  
Zhen‐Xing Ren ◽  
Yong‐Zhao Wang ◽  
Qiang Yu ◽  
...  
Keyword(s):  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Regioselective Synthesis

Enantioselective synthesis of chiral 3-alkyl-3-nitro-4-chromanones via chiral thiourea-catalysed intramolecular Michael-type cyclization

2021 ◽  
Author(s):  
Huiqing Chen ◽  
Jie Tang ◽  
Ting Liu ◽  
Li-Fang Yu ◽  
Dong Xing ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Cyclization Reaction ◽  
Rapid Construction

Herein we report an enantioselective method for the rapid construction of chiral 3-nitro-4-chromanones via a chiral thiourea-catalyzed intramolecular Michael-type cyclization reaction. With this method, a series of 3,3-disubstituted-3-nitro-4-chromanones bearing contiguous...

scholarly journals Synthesis and antibacterial activity of monocyclic 3-carboxamide tetramic acids

2013 ◽  
Vol 9 ◽  
pp. 1899-1906 ◽  
Author(s):  
Yong-Chul Jeong ◽  
Mark G Moloney
Keyword(s):  
Antibacterial Activity ◽  
Natural Products ◽  
Chemical Library ◽  
Rapid Construction ◽  
Tetramic Acids

A chemical library of carboxamide-substituted tetramates designed by analogy with antibacterial natural products, a method for their rapid construction, and the evaluation of their antibacterial activity is reported.

scholarly journals Expedient Access to Enantiopure Cyclopentanic Natural Products: Total Synthesis of (-)-Cyclonerodiol

2015 ◽  
Vol 10 (1) ◽  
pp. 1934578X1501000
Author(s):  
Carmen Pérez Morales ◽  
M. Mar Herrador ◽  
José F. Quílez del Moral ◽  
Alejandro F. Barrero
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Radical Cyclization ◽  
Formal Synthesis ◽  
Common Precursor ◽  
Enantiospecific Synthesis ◽  
Optically Pure

Following the principles of collective total synthesis, a number of natural products sharing an optically pure, multifunctional, cyclopentanic core were synthesized from a common precursor: plinol A (1). This intermediate was efficiently obtained in only four steps from (-)-linalool (2) using as the key step a Ti(III)-mediated diastereoselective radical cyclization. The feasibility of this approach was confirmed with the expedient enantiospecific synthesis of cyclonerodiol (3), and the formal synthesis of chocol G (4) and piperitone (5).

Rapid construction of complex tetracyclic frameworks via a gold(i)-catalyzed tandem 1,2-acyloxy migration/[3 + 2] cycloaddition/Friedel–Crafts type cyclization reaction of linear enynyl esters

2017 ◽  
Vol 4 (11) ◽  
pp. 2109-2113 ◽  
Author(s):  
Haiyu Sun ◽  
Shiyan Xu ◽  
Zhimin Xing ◽  
Lin Liu ◽  
Shangbiao Feng ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Quaternary Centers ◽  
Rapid Construction ◽  
One Step

Magic “Au”: 3 rings and 2–3 quaternary centers were constructed in one step!

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