Enantioselective synthesis of chiral 3-alkyl-3-nitro-4-chromanones via chiral thiourea-catalysed intramolecular Michael-type cyclization

2021 ◽  
Author(s):  
Huiqing Chen ◽  
Jie Tang ◽  
Ting Liu ◽  
Li-Fang Yu ◽  
Dong Xing ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Cyclization Reaction ◽  
Rapid Construction

Herein we report an enantioselective method for the rapid construction of chiral 3-nitro-4-chromanones via a chiral thiourea-catalyzed intramolecular Michael-type cyclization reaction. With this method, a series of 3,3-disubstituted-3-nitro-4-chromanones bearing contiguous...

Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A

2017 ◽  
Vol 4 (11) ◽  
pp. 2211-2215 ◽  
Author(s):  
Hao Zhang ◽  
Shiqiang Ma ◽  
Zhimin Xing ◽  
Lin Liu ◽  
Bowen Fang ◽  
...  
Keyword(s):  
Natural Products ◽  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Rapid Construction

A tandem radical cyclization towards the 6/6/5 tricyclic skeleton, which exists in numerous natural products, was developed in modest to good yields.

Enantioselective synthesis of pyrano[2,3-c]pyrrole via an organocatalytic [4 + 2] cyclization reaction of dioxopyrrolidines and azlactones

2019 ◽  
Vol 17 (16) ◽  
pp. 3945-3950 ◽  
Author(s):  
Yichen Wang ◽  
Yuzhen Chen ◽  
Xiaoping Li ◽  
Yukang Mao ◽  
Weiwen Chen ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Cyclization Reaction ◽  
Efficient Access

The present work provides a simple and efficient access to chiral pyrano[2,3-c]pyrrole via an asymmetric [4 + 2] cyclization reaction catalyzed by a cinchona-squaramide catalyst.

Rapid construction of complex tetracyclic frameworks via a gold(i)-catalyzed tandem 1,2-acyloxy migration/[3 + 2] cycloaddition/Friedel–Crafts type cyclization reaction of linear enynyl esters

2017 ◽  
Vol 4 (11) ◽  
pp. 2109-2113 ◽  
Author(s):  
Haiyu Sun ◽  
Shiyan Xu ◽  
Zhimin Xing ◽  
Lin Liu ◽  
Shangbiao Feng ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Quaternary Centers ◽  
Rapid Construction ◽  
One Step

Magic “Au”: 3 rings and 2–3 quaternary centers were constructed in one step!

Enantioselective total synthesis of (+)-arborescidine C and related tetracyclic indole alkaloids using organocatalysis

2017 ◽  
Vol 15 (16) ◽  
pp. 3408-3412 ◽  
Author(s):  
Vishal M. Sheth ◽  
Bor-Cherng Hong ◽  
Gene-Hsiang Lee
Keyword(s):  
Total Synthesis ◽  
Indole Alkaloids ◽  
Enantioselective Synthesis ◽  
Cyclization Reaction ◽  
Enantioselective Total Synthesis

Enantioselective synthesis of (+)-arborescidine C was achieved by the key step of Pictet–Spengler cyclization reaction with a Jacobsen-type thiourea organocatalyst.

Enantioselective synthesis of 1-aminoindene derivatives via asymmetric Brønsted acid catalysis

2021 ◽  
Author(s):  
Xiang Wu ◽  
Du Ding ◽  
Ying Zhang ◽  
Hua-Jie Jiang ◽  
Tao Wang ◽  
...  
Keyword(s):  
Acid Catalysis ◽  
Enantioselective Synthesis ◽  
Cyclization Reaction ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Brönsted Acid ◽  
Iminium Ion ◽  
Catalytic Asymmetric ◽  
Bronsted Acid Catalysis

We describe a catalytic asymmetric iminium ion cyclization reaction of simple 2-alkenylbenzaldimines using a BINOL-derived chiral N-triflyl phosphoramide. The corresponding 1-aminoindenes and tetracyclic 1-aminoindanes are formed in good yields and...

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