Degradable polyesters via ring-opening polymerization of functional valerolactones for efficient gene delivery

2017 ◽  
Vol 15 (31) ◽  
pp. 6567-6574 ◽  
Author(s):  
Ling Song ◽  
Ai-Xiang Ding ◽  
Ke-Xin Zhang ◽  
Bing Gong ◽  
Zhong-Lin Lu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ring Opening ◽  
Drug Carriers ◽  
Ring Opening Polymerization ◽  
Degradable Polymers ◽  
Efficient Gene ◽  
Degradable Polyesters

Degradable polymers as gene and drug carriers are emerging as one of the most promising types of materials in the biomedical and pharmaceutical areas.

Ring-opening polymerization of degradable polyesters

1998 ◽  
Vol 130 (1) ◽  
pp. 367-378 ◽  
Author(s):  
Kajsa Stridsberg ◽  
Mats Gruvegård ◽  
Ann-Christine Albertsson
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Degradable Polyesters

Diol glycidyl ether-bridged low molecular weight PEI as potential gene delivery vehicles

2015 ◽  
Vol 3 (13) ◽  
pp. 2660-2670 ◽  
Author(s):  
Qian Guo ◽  
Yan-Hong Liu ◽  
Miao-Miao Xun ◽  
Ji Zhang ◽  
Zheng Huang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Ring Opening ◽  
Transfection Efficiency ◽  
Glycidyl Ether ◽  
Ring Opening Polymerization ◽  
Low Molecular Weight ◽  
Delivery Vehicles ◽  
Gene Delivery Vehicles

PEI 600-based polymers were synthesized via ring-opening polymerization and exhibited much better transfection efficiency and biocompatibility than PEI 25 kDa.

Amphiphilic polymers formed from ring-opening polymerization: a strategy for the enhancement of gene delivery

2017 ◽  
Vol 5 (4) ◽  
pp. 718-729 ◽  
Author(s):  
Yi-Mei Zhang ◽  
Zheng Huang ◽  
Ji Zhang ◽  
Wan-Xia Wu ◽  
Yan-Hong Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ring Opening ◽  
Transfection Efficiency ◽  
Ring Opening Polymerization ◽  
Amphiphilic Polymers ◽  
Cationic Lipids ◽  
Promising Strategy

Ring-opening polymerization was found to be a promising strategy to improve the transfection efficiency and serum tolerance of cationic lipids.

Ring-Opening Polymerization for Hyperbranched Polycationic Gene Delivery Vectors with Excellent Serum Tolerance

2014 ◽  
Vol 6 (18) ◽  
pp. 15733-15742 ◽  
Author(s):  
Qin-Fang Zhang ◽  
Qing-Ying Yu ◽  
Yanyan Geng ◽  
Ji Zhang ◽  
Wan-Xia Wu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Gene Delivery Vectors

Degradable polymers from ring-opening polymerization of α-angelica lactone, a five-membered unsaturated lactone

2011 ◽  
Vol 2 (5) ◽  
pp. 1190 ◽  
Author(s):  
Tieniu Chen ◽  
Zhangfeng Qin ◽  
Yongqin Qi ◽  
Tiansheng Deng ◽  
Xiaojing Ge ◽  
...  
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Degradable Polymers ◽  
Unsaturated Lactone ◽  
Angelica Lactone

Cationic polymer-derived carbon dots for enhanced gene delivery and cell imaging

2019 ◽  
Vol 7 (5) ◽  
pp. 1940-1948 ◽  
Author(s):  
Xi He ◽  
Ping Chen ◽  
Ji Zhang ◽  
Tian-Ying Luo ◽  
Hai-Jiao Wang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Carbon Dots ◽  
Ring Opening ◽  
Cell Imaging ◽  
High Efficiency ◽  
Ring Opening Polymerization ◽  
Cationic Polymer ◽  
Cationic Polymers ◽  
Promising Strategy ◽  
Gene Vectors

The transformation of cationic polymers derived from ring-opening polymerization to carbon dots was proved as a promising strategy for developing gene vectors with high efficiency and cell-imaging ability.

scholarly journals Progress in the Preparation of Functional and (Bio)Degradable Polymers via Living Polymerizations

2020 ◽  
Vol 21 (24) ◽  
pp. 9581
Author(s):  
Si-Ting Lin ◽  
Chung-Chi Wang ◽  
Chi-Jung Chang ◽  
Yasuyuki Nakamura ◽  
Kun-Yi Andrew Lin ◽  
...  
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Synthetic Methods ◽  
Degradable Polymers ◽  
Radical Ring ◽  
Aliphatic Polyesters ◽  
Innovative Methods ◽  
Living Polymerizations ◽  
Step Growth ◽  
Synthetic Methodologies

This review presents the latest developments in (bio)degradable approaches and functional aliphatic polyesters and polycarbonates prepared by typical ring-opening polymerization (ROP) of lactones and trimethylene carbonates. It also considers several recent innovative synthetic methods including radical ring-opening polymerization (RROP), atom transfer radical polyaddition (ATRPA), and simultaneous chain- and step-growth radical polymerization (SCSRP) that produce aliphatic polyesters. With regard to (bio)degradable approaches, we have summarized several representative cleavable linkages that make it possible to obtain cleavable polymers. In the section on functional aliphatic polyesters, we explore the syntheses of specific functional lactones, which can be performed by ring-opening copolymerization of typical lactone/lactide monomers. Last but not the least, in the recent innovative methods section, three interesting synthetic methodologies, RROP, ATRPA, and SCSRP are discussed in detail with regard to their reaction mechanisms and polymer functionalities.

Sign in / Sign up

Export Citation Format

Share Document