Ring-Opening Polymerization for Hyperbranched Polycationic Gene Delivery Vectors with Excellent Serum Tolerance

2014 ◽  
Vol 6 (18) ◽  
pp. 15733-15742 ◽  
Author(s):  
Qin-Fang Zhang ◽  
Qing-Ying Yu ◽  
Yanyan Geng ◽  
Ji Zhang ◽  
Wan-Xia Wu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Gene Delivery Vectors

Linear polycations by ring-opening polymerization as non-viral gene delivery vectors

Biomaterials ◽  
2013 ◽  
Vol 34 (21) ◽  
pp. 5391-5401 ◽  
Author(s):  
Qin-Fang Zhang ◽  
Wen-Jing Yi ◽  
Bing Wang ◽  
Ji Zhang ◽  
Laifeng Ren ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Viral Gene ◽  
Gene Delivery Vectors ◽  
Viral Gene Delivery

Diol glycidyl ether-bridged low molecular weight PEI as potential gene delivery vehicles

2015 ◽  
Vol 3 (13) ◽  
pp. 2660-2670 ◽  
Author(s):  
Qian Guo ◽  
Yan-Hong Liu ◽  
Miao-Miao Xun ◽  
Ji Zhang ◽  
Zheng Huang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Ring Opening ◽  
Transfection Efficiency ◽  
Glycidyl Ether ◽  
Ring Opening Polymerization ◽  
Low Molecular Weight ◽  
Delivery Vehicles ◽  
Gene Delivery Vehicles

PEI 600-based polymers were synthesized via ring-opening polymerization and exhibited much better transfection efficiency and biocompatibility than PEI 25 kDa.

Amphiphilic polymers formed from ring-opening polymerization: a strategy for the enhancement of gene delivery

2017 ◽  
Vol 5 (4) ◽  
pp. 718-729 ◽  
Author(s):  
Yi-Mei Zhang ◽  
Zheng Huang ◽  
Ji Zhang ◽  
Wan-Xia Wu ◽  
Yan-Hong Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ring Opening ◽  
Transfection Efficiency ◽  
Ring Opening Polymerization ◽  
Amphiphilic Polymers ◽  
Cationic Lipids ◽  
Promising Strategy

Ring-opening polymerization was found to be a promising strategy to improve the transfection efficiency and serum tolerance of cationic lipids.

Cationic polymer-derived carbon dots for enhanced gene delivery and cell imaging

2019 ◽  
Vol 7 (5) ◽  
pp. 1940-1948 ◽  
Author(s):  
Xi He ◽  
Ping Chen ◽  
Ji Zhang ◽  
Tian-Ying Luo ◽  
Hai-Jiao Wang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Carbon Dots ◽  
Ring Opening ◽  
Cell Imaging ◽  
High Efficiency ◽  
Ring Opening Polymerization ◽  
Cationic Polymer ◽  
Cationic Polymers ◽  
Promising Strategy ◽  
Gene Vectors

The transformation of cationic polymers derived from ring-opening polymerization to carbon dots was proved as a promising strategy for developing gene vectors with high efficiency and cell-imaging ability.

scholarly journals Polyglycerol-functionalized nanodiamond as a platform for gene delivery: Derivatization, characterization, and hybridization with DNA

2014 ◽  
Vol 10 ◽  
pp. 707-713 ◽  
Author(s):  
Li Zhao ◽  
Yuki Nakae ◽  
Hongmei Qin ◽  
Tadamasa Ito ◽  
Takahide Kimura ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Zeta Potential ◽  
Plasmid Dna ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Gene Vector ◽  
Organic Transformations ◽  
Gel Retardation Assay ◽  
Basic Polypeptides ◽  
Basic Polypeptide

A gene vector consisting of nanodiamond, polyglycerol, and basic polypeptide (ND-PG-BPP) has been designed, synthesized, and characterized. The ND-PG-BPP was synthesized by PG functionalization of ND through ring-opening polymerization of glycidol on the ND surface, multistep organic transformations (–OH → –OTs (tosylate) → –N3) in the PG layer, and click conjugation of the basic polypeptides (Arg8, Lys8 or His8) terminated with propargyl glycine. The ND-PG-BPP exhibited good dispersibility in water (>1.0 mg/mL) and positive zeta potential ranging from +14.2 mV to +44.1 mV at neutral pH in Milli-Q water. It was confirmed by gel retardation assay that ND-PG-Arg8 and ND-PG-Lys8 with higher zeta potential hybridized with plasmid DNA (pDNA) through electrostatic attraction, making them promising as nonviral vectors for gene delivery.

Bio-reducible polycations from ring-opening polymerization as potential gene delivery vehicles

2016 ◽  
Vol 14 (27) ◽  
pp. 6470-6478 ◽  
Author(s):  
Qing-Ying Yu ◽  
Yan-Hong Liu ◽  
Zheng Huang ◽  
Ji Zhang ◽  
Chao-Ran Luan ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ring Opening ◽  
Transfection Efficiency ◽  
Ring Opening Polymerization ◽  
Dna Condensation ◽  
Molecular Weights ◽  
Delivery Vehicles ◽  
Gene Delivery Vehicles

Bio-reducible polycations were prepared via ring-opening polymerization. These materials have relatively low molecular weights and cytotoxicity but have good DNA condensation ability, transfection efficiency and excellent serum tolerance.

Ring-opening polymerization of diepoxides as an alternative method to overcome PEG dilemma in gene delivery

Polymer ◽  
2018 ◽  
Vol 134 ◽  
pp. 53-62 ◽  
Author(s):  
Ya-Ping Xiao ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
Xiao-Chuan Chen ◽  
Qing-Ying Yu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Alternative Method

scholarly journals An amphiphilic non-viral gene vector prepared by a combination of enzymatic atom transfer radical polymerization and enzymatic ring-opening polymerization

RSC Advances ◽  
2017 ◽  
Vol 7 (16) ◽  
pp. 9926-9932 ◽  
Author(s):  
Xinghuo Wang ◽  
Wenjing Yun ◽  
Wei Jiang ◽  
Ding Wang ◽  
Ling Zhang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Viral Gene ◽  
Atom Transfer ◽  
Gene Vector ◽  
First Time ◽  
Kinetic Features

An amphiphilic non-viral gene vector (PCL-b-PGEA) was prepared by a combination of enzymatic ring-opening polymerization and enzymatic atom transfer radical polymerization for the first time and the kinetic features and gene delivery properties were investigated.

Degradable polyesters via ring-opening polymerization of functional valerolactones for efficient gene delivery

2017 ◽  
Vol 15 (31) ◽  
pp. 6567-6574 ◽  
Author(s):  
Ling Song ◽  
Ai-Xiang Ding ◽  
Ke-Xin Zhang ◽  
Bing Gong ◽  
Zhong-Lin Lu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ring Opening ◽  
Drug Carriers ◽  
Ring Opening Polymerization ◽  
Degradable Polymers ◽  
Efficient Gene ◽  
Degradable Polyesters

Degradable polymers as gene and drug carriers are emerging as one of the most promising types of materials in the biomedical and pharmaceutical areas.

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