Targeted photodynamic therapy in visible light using BODIPY-appended copper(ii) complexes of a vitamin B6Schiff base

2018 ◽  
Vol 47 (3) ◽  
pp. 823-835 ◽  
Author(s):  
Nandini Mukherjee ◽  
Santosh Podder ◽  
Koushambi Mitra ◽  
Shamik Majumdar ◽  
Dipankar Nandi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Visible Light ◽  
Cancer Cell ◽  
Vitamin B ◽  
Targeted Photodynamic Therapy

BODIPY-appended copper(ii) complexes of vitamin B6derivatives localize in mitochondria and exhibit cancer cell selective photocytotoxicity by1O2mediated apoptosis.

A DNA-functionalized biomass nanoprobe for the targeted photodynamic therapy of tumor and ratiometric fluorescence imaging-based visual cancer cell identification/antitumor drug screening

The Analyst ◽  
2021 ◽  
Author(s):  
Pengxiang Lin ◽  
Liangliang Zhang ◽  
Dongxia Chen ◽  
Jiayao Xu ◽  
Yulong Bai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Cancer Cell ◽  
Drug Screening ◽  
Antitumor Drug ◽  
Ratiometric Fluorescence ◽  
Cell Identification ◽  
Targeted Photodynamic Therapy

A DNA-functionalized biomass nanoprobe was developed for the targeted photodynamic therapy of tumor and ratiometric fluorescence imaging-based visual cancer cell identification/antitumor drug screening.

Cancer cell membrane-coated biomimetic platform for tumor targeted photodynamic therapy and hypoxia-amplified bioreductive therapy

Biomaterials ◽  
2017 ◽  
Vol 142 ◽  
pp. 149-161 ◽  
Author(s):  
Shi-Ying Li ◽  
Hong Cheng ◽  
Wen-Xiu Qiu ◽  
Lu Zhang ◽  
Shuang-Shuang Wan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Targeted Photodynamic Therapy

Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(iii) complexes

2017 ◽  
Vol 53 (71) ◽  
pp. 9878-9881 ◽  
Author(s):  
Jiangping Liu ◽  
Chengzhi Jin ◽  
Bo Yuan ◽  
Yu Chen ◽  
Xingguo Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Cancer Cell ◽  
Tumor Spheroids ◽  
Two Photon ◽  
Metabolic Alteration ◽  
Targeted Photodynamic Therapy

A series of DCA-Ir(iii) co-drug complexes were demonstrated to act in synergy by sensitizing cancer cell for PDT to achieve cancer-specifically enhanced two-photon PDT in the hypoxic muticellular tumor spheroids.

G-quadruplex/protoporphyrin IX-functionalized silver nanoconjugates for targeted cancer cell photodynamic therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (99) ◽  
pp. 96942-96945 ◽  
Author(s):  
Jun Ai ◽  
Jing Li ◽  
Lu Ga ◽  
Guohong Yun ◽  
Li Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Surface ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Specific Interaction ◽  
Protoporphyrin Ix ◽  
Photodynamic Therapy Of Cancer ◽  
G Quadruplex ◽  
New Type ◽  
Targeted Photodynamic Therapy

A new type of G-quadruplex/protoporphyrin IX-functionalized silver nanoconjugate was prepared and used for the targeted photodynamic therapy of cancer cells via the specific interaction between AS1411 and the nucleolin on the cell surface.

A cyanine-derivative photosensitizer with enhanced photostability for mitochondria-targeted photodynamic therapy

2019 ◽  
Vol 55 (90) ◽  
pp. 13542-13545 ◽  
Author(s):  
Xuan Zhao ◽  
Yanjun Yang ◽  
Yan Yu ◽  
Siming Guo ◽  
Wenxing Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Targeted Photodynamic Therapy ◽  
Enhanced Photostability ◽  
Excellent Photostability

A cyanine-derivative photosensitizer was synthesized with excellent photostability for photodynamic therapy via targeting the cancer cell mitochondria.

Scavenger-Receptor Targeted Photodynamic Therapy¶

2000 ◽  
Vol 72 (4) ◽  
pp. 533 ◽  
Author(s):  
Michael R. Hamblin ◽  
Jaimie L. Miller ◽  
Bernhard Ortel
Keyword(s):  
Photodynamic Therapy ◽  
Scavenger Receptor ◽  
Targeted Photodynamic Therapy

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

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