Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(iii) complexes

2017 ◽  
Vol 53 (71) ◽  
pp. 9878-9881 ◽  
Author(s):  
Jiangping Liu ◽  
Chengzhi Jin ◽  
Bo Yuan ◽  
Yu Chen ◽  
Xingguo Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Cancer Cell ◽  
Tumor Spheroids ◽  
Two Photon ◽  
Metabolic Alteration ◽  
Targeted Photodynamic Therapy

A series of DCA-Ir(iii) co-drug complexes were demonstrated to act in synergy by sensitizing cancer cell for PDT to achieve cancer-specifically enhanced two-photon PDT in the hypoxic muticellular tumor spheroids.

A two-photon AIE fluorophore as a photosensitizer for highly efficient mitochondria-targeted photodynamic therapy

2020 ◽  
Vol 44 (22) ◽  
pp. 9355-9364 ◽  
Author(s):  
Qunshou Kong ◽  
Boxuan Ma ◽  
Tao Yu ◽  
Cheng Hu ◽  
Gaocan Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Two Photon ◽  
Highly Efficient ◽  
Targeted Photodynamic Therapy

Nowadays, photodynamic therapy (PDT) has become an effective method for cancer therapy.

A DNA-functionalized biomass nanoprobe for the targeted photodynamic therapy of tumor and ratiometric fluorescence imaging-based visual cancer cell identification/antitumor drug screening

The Analyst ◽  
2021 ◽  
Author(s):  
Pengxiang Lin ◽  
Liangliang Zhang ◽  
Dongxia Chen ◽  
Jiayao Xu ◽  
Yulong Bai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Cancer Cell ◽  
Drug Screening ◽  
Antitumor Drug ◽  
Ratiometric Fluorescence ◽  
Cell Identification ◽  
Targeted Photodynamic Therapy

A DNA-functionalized biomass nanoprobe was developed for the targeted photodynamic therapy of tumor and ratiometric fluorescence imaging-based visual cancer cell identification/antitumor drug screening.

Cancer cell membrane-coated biomimetic platform for tumor targeted photodynamic therapy and hypoxia-amplified bioreductive therapy

Biomaterials ◽  
2017 ◽  
Vol 142 ◽  
pp. 149-161 ◽  
Author(s):  
Shi-Ying Li ◽  
Hong Cheng ◽  
Wen-Xiu Qiu ◽  
Lu Zhang ◽  
Shuang-Shuang Wan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Targeted Photodynamic Therapy

scholarly journals Two-photon excitable boron complex based on tridentate imidazo[1,5-a]pyridine ligand for heavy-atom-free mitochondria-targeted photodynamic therapy

RSC Advances ◽  
2021 ◽  
Vol 11 (42) ◽  
pp. 26403-26407
Author(s):  
Keita Hoshi ◽  
Masami Itaya ◽  
Koki Tahara ◽  
Airi Matsumoto ◽  
Atsuhi Tabata ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Heavy Atom ◽  
Pyridine Ligand ◽  
Two Photon ◽  
Boron Complex ◽  
Targeted Photodynamic Therapy

We have synthesized a cyan fluorescent boron complex based on a tridentate imidazo[1,5-a]pyridine ligand.

Inner salt-shaped small molecular photosensitizer with extremely enhanced two-photon absorption for mitochondrial-targeted photodynamic therapy

2017 ◽  
Vol 53 (10) ◽  
pp. 1680-1683 ◽  
Author(s):  
Wenbo Hu ◽  
Tingchao He ◽  
Rongcui Jiang ◽  
Jun Yin ◽  
Lin Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photon Absorption ◽  
Mitochondrial Apoptosis ◽  
Apoptosis Pathway ◽  
Mitochondrial Apoptosis Pathway ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Highly Efficient ◽  
Targeted Photodynamic Therapy

An inner salt-shaped small-molecular photosensitizer with unprecedentedly strong two-photon absorption was developed for highly efficient two-photon photodynamic therapyviaa mitochondrial apoptosis pathway.

Two- and three-photon excitable quaternized imidazo[1,2-a]pyridines as mitochondrial imaging and potent cancer therapy agents

2020 ◽  
Vol 18 (38) ◽  
pp. 7571-7576
Author(s):  
Eiji Hase ◽  
Hiroki Takanari ◽  
Keita Hoshi ◽  
Masaki Okamoto ◽  
Atsushi Tabata ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Imaging Agent ◽  
Targeted Photodynamic Therapy ◽  
Photon Fluorescence

We have synthesized four blue fluorescent imidazo[1,2-a]pyridines. One specific compound work as not only a two- and three-photon fluorescence imaging agent for the visualization of mitochondria, but also a potent mitochondria-targeted photodynamic therapy agent.

G-quadruplex/protoporphyrin IX-functionalized silver nanoconjugates for targeted cancer cell photodynamic therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (99) ◽  
pp. 96942-96945 ◽  
Author(s):  
Jun Ai ◽  
Jing Li ◽  
Lu Ga ◽  
Guohong Yun ◽  
Li Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Surface ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Specific Interaction ◽  
Protoporphyrin Ix ◽  
Photodynamic Therapy Of Cancer ◽  
G Quadruplex ◽  
New Type ◽  
Targeted Photodynamic Therapy

A new type of G-quadruplex/protoporphyrin IX-functionalized silver nanoconjugate was prepared and used for the targeted photodynamic therapy of cancer cells via the specific interaction between AS1411 and the nucleolin on the cell surface.

A cyanine-derivative photosensitizer with enhanced photostability for mitochondria-targeted photodynamic therapy

2019 ◽  
Vol 55 (90) ◽  
pp. 13542-13545 ◽  
Author(s):  
Xuan Zhao ◽  
Yanjun Yang ◽  
Yan Yu ◽  
Siming Guo ◽  
Wenxing Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Targeted Photodynamic Therapy ◽  
Enhanced Photostability ◽  
Excellent Photostability

A cyanine-derivative photosensitizer was synthesized with excellent photostability for photodynamic therapy via targeting the cancer cell mitochondria.

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