G-quadruplex/protoporphyrin IX-functionalized silver nanoconjugates for targeted cancer cell photodynamic therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (99) ◽  
pp. 96942-96945 ◽  
Author(s):  
Jun Ai ◽  
Jing Li ◽  
Lu Ga ◽  
Guohong Yun ◽  
Li Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Surface ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Specific Interaction ◽  
Protoporphyrin Ix ◽  
Photodynamic Therapy Of Cancer ◽  
G Quadruplex ◽  
New Type ◽  
Targeted Photodynamic Therapy

A new type of G-quadruplex/protoporphyrin IX-functionalized silver nanoconjugate was prepared and used for the targeted photodynamic therapy of cancer cells via the specific interaction between AS1411 and the nucleolin on the cell surface.

scholarly journals Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells

2018 ◽  
Author(s):  
Alicja Sznarkowska ◽  
Anna Kostecka ◽  
Anna Kawiak ◽  
Pilar Acedo ◽  
Mattia Lion ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Practice ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
Drug Repurposing ◽  
Functional Similarity ◽  
Photodynamic Therapy Of Cancer

AbstractBackgroundThe p73 protein is a tumor suppressor that shares structural and functional similarity with p53. p73 is expressed in two major isoforms; the TA isoform that interacts with p53 pathway, thus acting as tumor suppressor and the N-terminal truncated ΔN isoform that inhibits TAp73 and p53 and thus, acts as an oncogene.ResultsBy employing a drug repurposing approach, we found that protoporphyrin IX (PpIX), a metabolite of aminolevulinic acid (ALA) applied in photodynamic therapy of cancer, stabilizes TAp73 and activates TAp73-dependent apoptosis in cancer cells lacking p53. The mechanism of TAp73 activation is via disruption of TAp73/MDM2 and TAp73/MDMX interactions and inhibition of TAp73 degradation by ubiquitin ligase Itch.ConclusionOur findings may in future contribute to the successful repurposing of PpIX into clinical practice.

PLGA nanocomposites loaded with verteporfin and gold nanoparticles for enhanced photodynamic therapy of cancer cells

RSC Advances ◽  
2016 ◽  
Vol 6 (113) ◽  
pp. 112393-112402 ◽  
Author(s):  
Wei Deng ◽  
Zofia Kautzka ◽  
Wenjie Chen ◽  
Ewa M Goldys
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Killing ◽  
Light Illumination ◽  
Killing Effect ◽  
Photodynamic Therapy Of Cancer ◽  
Cell Killing Effect

Enhanced 1O2 generation from PLGA loaded with verteporfin and gold nanoparticles under light illumination has the potential to improve cancer cell-killing effect.

Multimodal Upconversion Nanoplatform with a Mitochondria-Targeted Property for Improved Photodynamic Therapy of Cancer Cells

2016 ◽  
Vol 55 (8) ◽  
pp. 3872-3880 ◽  
Author(s):  
Xiaoman Zhang ◽  
Fujin Ai ◽  
Tianying Sun ◽  
Feng Wang ◽  
Guangyu Zhu
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Photodynamic Therapy Of Cancer

Selenorhodamine photosensitizers with the Texas-red core for photodynamic therapy of cancer cells

2015 ◽  
Vol 23 (15) ◽  
pp. 4501-4507 ◽  
Author(s):  
Mark W. Kryman ◽  
Kellie S. Davies ◽  
Michelle K. Linder ◽  
Tymish Y. Ohulchanskyy ◽  
Michael R. Detty
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Photodynamic Therapy Of Cancer ◽  
Red Core ◽  
Texas Red

scholarly journals MASKING ANTI-PHAGOCYTIC SIGNAL OF TUMOR BY PRO-PHAGOCYTIC SIGNAL-A KEY TO IMMUREMENT OF CANCER CELL

2016 ◽  
Vol 8 (9) ◽  
pp. 323
Author(s):  
Madheswaran Suresh ◽  
Malarvizhi Gurusamy ◽  
Natarajan Sudhakar
Keyword(s):  
Breast Cancer ◽  
Immune System ◽  
Breast Carcinoma ◽  
Cell Surface ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Immune Surveillance ◽  
Phagocytic Cell ◽  
Surveillance Mechanism

<p>Immune surveillance is a mechanism where cells and tissues are watched constantly by ever alerted immune system. Most incipient cancer cells are recognized and eliminated by the immune surveillance mechanism, but still tumors have the ability to evade immune surveillance and immunological killing. One greater arm that tumor use to evade immune surveillance, is by expressing anti-phagocytic signal (CD47). Here we present a provocative hypothesis where cancer cells are removed alive by phagocytic cell (DC). That in turn will elicit effective and higher immunogenic condition. All this could be possible by addition pro-phagocytic signal (PtdSer) over cancer cell surface (Breast Cancer), that mask the presence of anti-phagocytic signal (CD47). In other words, adding eat me signal (PtdSer) over the breast cancer cell surface that mask the presence of don’t eat me signal or anti-phagocytic signal present in breast cancer cell surface. This could be possible by using bi-specific antibody, conjugated to PEG-modified liposomes, which carry (PtdSer) pro-phagocytic signal (or) eat me signal, which target both CD47 and EGFRVIII on breast carcinoma. The simultaneous masking of anti-phagocytic signal, and adding of pro–phagocytic signal over cancer cell, will enhance the phagocytic clearance of live tumor cell and elicit immunological killing.</p>

scholarly journals eEF1A1 binds and enriches protoporphyrin IX in cancer cells in 5-aminolevulinic acid based photodynamic therapy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Zhichao Fan ◽  
Xiaojun Cui ◽  
Dan Wei ◽  
Wei Liu ◽  
Buhong Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix
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