A two-photon AIE fluorophore as a photosensitizer for highly efficient mitochondria-targeted photodynamic therapy

2020 ◽  
Vol 44 (22) ◽  
pp. 9355-9364 ◽  
Author(s):  
Qunshou Kong ◽  
Boxuan Ma ◽  
Tao Yu ◽  
Cheng Hu ◽  
Gaocan Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Two Photon ◽  
Highly Efficient ◽  
Targeted Photodynamic Therapy

Nowadays, photodynamic therapy (PDT) has become an effective method for cancer therapy.

Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(iii) complexes

2017 ◽  
Vol 53 (71) ◽  
pp. 9878-9881 ◽  
Author(s):  
Jiangping Liu ◽  
Chengzhi Jin ◽  
Bo Yuan ◽  
Yu Chen ◽  
Xingguo Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Cancer Cell ◽  
Tumor Spheroids ◽  
Two Photon ◽  
Metabolic Alteration ◽  
Targeted Photodynamic Therapy

A series of DCA-Ir(iii) co-drug complexes were demonstrated to act in synergy by sensitizing cancer cell for PDT to achieve cancer-specifically enhanced two-photon PDT in the hypoxic muticellular tumor spheroids.

Inner salt-shaped small molecular photosensitizer with extremely enhanced two-photon absorption for mitochondrial-targeted photodynamic therapy

2017 ◽  
Vol 53 (10) ◽  
pp. 1680-1683 ◽  
Author(s):  
Wenbo Hu ◽  
Tingchao He ◽  
Rongcui Jiang ◽  
Jun Yin ◽  
Lin Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photon Absorption ◽  
Mitochondrial Apoptosis ◽  
Apoptosis Pathway ◽  
Mitochondrial Apoptosis Pathway ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Highly Efficient ◽  
Targeted Photodynamic Therapy

An inner salt-shaped small-molecular photosensitizer with unprecedentedly strong two-photon absorption was developed for highly efficient two-photon photodynamic therapyviaa mitochondrial apoptosis pathway.

scholarly journals Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens

2020 ◽  
Vol 11 (9) ◽  
pp. 2494-2503 ◽  
Author(s):  
Zheng Zheng ◽  
Haixiang Liu ◽  
Shaodong Zhai ◽  
Haoke Zhang ◽  
Guogang Shan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Molecular Engineering ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Highly Efficient

Mitochondria-targeted photosensitizers with highly efficient singlet oxygen generation, bright near-infrared AIE and good two-photon absorption are obtained through ingenious molecular engineering for cancer cell-selective photodynamic therapy.

scholarly journals Two-photon excitable boron complex based on tridentate imidazo[1,5-a]pyridine ligand for heavy-atom-free mitochondria-targeted photodynamic therapy

RSC Advances ◽  
2021 ◽  
Vol 11 (42) ◽  
pp. 26403-26407
Author(s):  
Keita Hoshi ◽  
Masami Itaya ◽  
Koki Tahara ◽  
Airi Matsumoto ◽  
Atsuhi Tabata ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Heavy Atom ◽  
Pyridine Ligand ◽  
Two Photon ◽  
Boron Complex ◽  
Targeted Photodynamic Therapy

We have synthesized a cyan fluorescent boron complex based on a tridentate imidazo[1,5-a]pyridine ligand.

Rational assembly of a biointerfaced core@shell nanocomplex towards selective and highly efficient synergistic photothermal/photodynamic therapy

Nanoscale ◽  
2015 ◽  
Vol 7 (47) ◽  
pp. 20197-20210 ◽  
Author(s):  
Chenchen Qin ◽  
Jinbo Fei ◽  
Anhe Wang ◽  
Yang Yang ◽  
Junbai Li
Keyword(s):  
Photodynamic Therapy ◽  
Core Shell ◽  
Two Photon ◽  
Highly Efficient ◽  
Shell Nanostructures

A biointerfaced nanocomplex with well-defined core@shell nanostructures is rationally assembled for combining photothermal and photodynamic therapy in a one-time synergistic manner under NIR two-photon illumination.

Two- and three-photon excitable quaternized imidazo[1,2-a]pyridines as mitochondrial imaging and potent cancer therapy agents

2020 ◽  
Vol 18 (38) ◽  
pp. 7571-7576
Author(s):  
Eiji Hase ◽  
Hiroki Takanari ◽  
Keita Hoshi ◽  
Masaki Okamoto ◽  
Atsushi Tabata ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Imaging Agent ◽  
Targeted Photodynamic Therapy ◽  
Photon Fluorescence

We have synthesized four blue fluorescent imidazo[1,2-a]pyridines. One specific compound work as not only a two- and three-photon fluorescence imaging agent for the visualization of mitochondria, but also a potent mitochondria-targeted photodynamic therapy agent.

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