scholarly journals Dynamic studies of the interaction of a pH responsive, amphiphilic polymer with a DOPC lipid membrane

Soft Matter ◽  
2017 ◽  
Vol 13 (20) ◽  
pp. 3690-3700 ◽  
Author(s):  
Sivaramakrishnan Ramadurai ◽  
Marco Werner ◽  
Nigel K. H. Slater ◽  
Aaron Martin ◽  
Vladimir A. Baulin ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Amphiphilic Polymer ◽  
Ph Responsive ◽  
Dynamic Studies

Double-networks based on pH-responsive, amphiphilic “core-first” star first polymer conetworks prepared by sequential RAFT polymerization

2017 ◽  
Vol 8 (1) ◽  
pp. 245-259 ◽  
Author(s):  
Elina N. Kitiri ◽  
Costas S. Patrickios ◽  
Chrysovalantis Voutouri ◽  
Triantafyllos Stylianopoulos ◽  
Ingo Hoffmann ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Raft Polymerization ◽  
Amphiphilic Polymer ◽  
Ph Responsive ◽  
Nanophase Separation ◽  
Double Networks

Double-networks based on amphiphilic polymer conetworks synthesized using RAFT polymerization were prepared, exhibiting pH-responsiveness, nanophase separation and enhanced mechanical properties.

Diazonaphthoquinone-based amphiphilic polymer assemblies for NIR/UV light- and pH-responsive controlled release

2018 ◽  
Vol 9 (4) ◽  
pp. 463-471 ◽  
Author(s):  
Qingwei Li ◽  
Ziquan Cao ◽  
Guojie Wang
Keyword(s):  
Controlled Release ◽  
Uv Light ◽  
Amphiphilic Polymer ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Responsive Polymer ◽  
Self Assembled ◽  
Stimuli Responsive Polymer ◽  
Ph Controlled

A multiple-stimuli-responsive polymer nanocarrier has been self-assembled for NIR/UV light- and pH-controlled cargo release.

Folic acid targeted pH-responsive amphiphilic polymer nanoparticles conjugated with near infrared fluorescence probe for imaging-guided drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (46) ◽  
pp. 40312-40322 ◽  
Author(s):  
Liyi Fu ◽  
Le Liu ◽  
Zheng Ruan ◽  
Houbing Zhang ◽  
Lifeng Yan
Keyword(s):  
Folic Acid ◽  
Ring Opening ◽  
Near Infrared ◽  
Fluorescence Probe ◽  
Click Reaction ◽  
Raft Polymerization ◽  
Ring Opening Polymerization ◽  
Amphiphilic Polymer ◽  
Polymer Nanoparticles ◽  
Ph Responsive

A novel folic acid targeted pH-responsive amphiphilic polymer conjugated with near infrared (NIR) probe has been synthesized by the combination of RAFT polymerization, ring-opening polymerization of N-carboxy anhydride (NCA) and click reaction.

Chiral pH-Responsive Amphiphilic Polymer Co-networks: Preparation, Chiral Recognition, and Release Abilities

2013 ◽  
Vol 214 (12) ◽  
pp. 1375-1383 ◽  
Author(s):  
Lu Shi ◽  
Peng Xie ◽  
Zhimin Li ◽  
Youping Wu ◽  
Jianping Deng
Keyword(s):  
Chiral Recognition ◽  
Amphiphilic Polymer ◽  
Ph Responsive

Biomedical Applications of pH-Responsive Amphiphilic Polymer Nanoassemblies

2020 ◽  
Vol 3 (3) ◽  
pp. 2104-2117 ◽  
Author(s):  
Shivshankar R. Mane ◽  
Ashlin Sathyan ◽  
Raja Shunmugam
Keyword(s):  
Biomedical Applications ◽  
Amphiphilic Polymer ◽  
Ph Responsive

PDEA-Based Amphiphilic Polymer Enables pH-Responsive Emulsions for a Rapid Demulsification

2019 ◽  
Author(s):  
Qingfeng Hou ◽  
Xiaobo Zheng ◽  
Donghong Guo ◽  
Youyi Zhu ◽  
Hui Yang ◽  
...  
Keyword(s):  
Amphiphilic Polymer ◽  
Ph Responsive

Structural Effects and Lipid Membrane Interactions of the pH-Responsive GALA Peptide with Fatty Acid Acylation

Biochemistry ◽  
2012 ◽  
Vol 51 (23) ◽  
pp. 4658-4668 ◽  
Author(s):  
Brian F. Lin ◽  
Dimitris Missirlis ◽  
Daniel V. Krogstad ◽  
Matthew Tirrell
Keyword(s):  
Fatty Acid ◽  
Lipid Membrane ◽  
Ph Responsive ◽  
Structural Effects ◽  
Membrane Interactions

Interaction of a pH-Responsive Designed Nanostructured Peptide with a Model Lipid Membrane

2016 ◽  
Vol 16 (8) ◽  
pp. 8528-8532
Author(s):  
Givaldo C Amaral ◽  
Analu R Costa ◽  
Paulo R. S Sanches ◽  
Eduardo M Cilli ◽  
Luiz C Salay
Keyword(s):  
Lipid Membrane ◽  
Ph Responsive

pH-Responsive and selective protein adsorption on an amino acid-based zwitterionic polymer surface

2015 ◽  
Vol 6 (39) ◽  
pp. 7053-7059 ◽  
Author(s):  
Shota Fujii ◽  
Makoto Kido ◽  
Masanao Sato ◽  
Yuji Higaki ◽  
Tomoyasu Hirai ◽  
...  
Keyword(s):  
Amino Acid ◽  
Protein Adsorption ◽  
Polymer Surface ◽  
Amphiphilic Polymer ◽  
Side Chain ◽  
Ph Responsive ◽  
Surface Modifier ◽  
Protein Properties ◽  
Zwitterionic Polymer ◽  
Polymer Bearing

An amphiphilic polymer bearing glutamic acid in the polymer side chain was used as a surface modifier to produce an amino acid-based zwitterionic surface with pH-responsive and selective protein properties.

scholarly journals Effect of Amyloid-β Monomers on Lipid Membrane Mechanical Parameters–Potential Implications for Mechanically Driven Neurodegeneration in Alzheimer’s Disease

2020 ◽  
Vol 22 (1) ◽  
pp. 18
Author(s):  
Dominik Drabik ◽  
Grzegorz Chodaczek ◽  
Sebastian Kraszewski
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Wave Propagation ◽  
Molecular Dynamic ◽  
Lipid Membrane ◽  
Flicker Noise ◽  
Alternative Hypothesis ◽  
Amyloid Β ◽  
Gamma Oscillations ◽  
Dynamic Studies

Alzheimer’s disease (AD) is a neurodegenerative disease that results in memory loss and the impairment of cognitive skills. Several mechanisms of AD’s pathogenesis were proposed, such as the progressive accumulation of amyloid-β (Aβ) and τ pathology. Nevertheless, the exact neurodegenerative mechanism of the Aβ remains complex and not fully understood. This paper proposes an alternative hypothesis of the mechanism based on maintaining the neuron membrane’s mechanical balance. The incorporation of Aβ decreases the lipid membrane’s elastic properties, which eventually leads to the impairment of membrane clustering, disruption of mechanical wave propagation, and change in gamma oscillations. The first two disrupt the neuron’s ability to function correctly while the last one decreases sensory encoding and perception enabling. To begin discussing this mechanical-balance hypothesis, we measured the effect of two selected peptides, Aβ-40 and Aβ-42, as well as their fluorescently labeled modification, on membrane mechanical properties. The decrease of bending rigidity, consistent for all investigated peptides, was observed using molecular dynamic studies and experimental flicker-noise techniques. Additionally, wave propagation was investigated with molecular dynamic studies in membranes with and without incorporated neurodegenerative peptides. A change in membrane behavior was observed in the membrane system with incorporated Aβ.

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